Tax1-expressing feline 8C cells are useful to monitor the life cycle of human T-cell leukemia virus type I
Mori, Takahisa and Shimizu, Nobuaki and Jinno-Oue, Atsushi and Tanaka, Atsushi and Shinagawa, Masahiko and Tokizawa, Shigemi and Akagi, Tsuyoshi and Hoshino, Hiroo,, 93, 588-593 (2012),
doi = https://doi.org/10.1099/vir.0.037382-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Extremely low infectivity has hampered direct (cell-free) infection studies of human T-cell leukemia virus type I (HTLV-I). In order to break through this barrier, we examined the susceptibility of many kinds of cells to HTLV-I and found a feline kidney cell line, 8C, that is highly susceptible to HTLV-I and produced remarkable amounts of infectious progeny viruses. Tax1 protein encoded by HTLV-I is known as a transcription activator for viral and cellular genes. We found that the 8C cells expressing the Tax1 protein (8C/TaxWT cells) can produce more progeny viruses than 8C cells when the cells were exposed to cell-free HTLV-I. A large number of syncytia were also induced in these cells. Here, we propose 8C/TaxWT cells as a useful tool to study the cell-free HTLV-I infection.,
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