1887

Abstract

We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species , which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5′ UTR and the VP1 protein, as well as recombination within the non-structural genes. Our findings and review of published sequences suggests that several novel human enterovirus C serotypes are currently circulating worldwide.

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2013-01-01
2024-04-20
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References

  1. Arnold K., Bordoli L., Kopp J., Schwede T. 2006; The swiss-model workspace: a web-based environment for protein structure homology modelling. Bioinformatics 22:195–201 [View Article][PubMed]
    [Google Scholar]
  2. Bessaud M., Joffret M. L., Holmblat B., Razafindratsimandresy R., Delpeyroux F. 2011; Genetic relationship between cocirculating human enteroviruses species C. PLoS ONE 6:e24823 [View Article][PubMed]
    [Google Scholar]
  3. Briese T., Palacios G., Kokoris M., Jabado O., Liu Z., Renwick N., Kapoor V., Casas I., Pozo F. other authors 2005; Diagnostic system for rapid and sensitive differential detection of pathogens. Emerg Infect Dis 11:310–313 [View Article][PubMed]
    [Google Scholar]
  4. Brown B., Oberste M. S., Maher K., Pallansch M. A. 2003; Complete genomic sequencing shows that polioviruses and members of human enterovirus species C are closely related in the noncapsid coding region. J Virol 77:8973–8984 [View Article][PubMed]
    [Google Scholar]
  5. Grard G., Drexler J. F., Lekana-Douki S., Caron M., Lukashev A., Nkoghe D., Gonzalez J. P., Drosten C., Leroy E. 2010; Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October–November 2010. Euro Surveill 15:19723[PubMed]
    [Google Scholar]
  6. Kaida A., Kubo H., Sekiguchi J., Hase A., Iritani N. 2012; Enterovirus 104 infection in adult, Japan, 2011. Emerg Infect Dis 18:882–883 [View Article][PubMed]
    [Google Scholar]
  7. Knowles N. J., Hovi T., Hyypiä T., King A. M. Q., Lindberg A. M., Pallansch M. A., Palmenberg A. C., Simmonds P., Skern T. other authors 2012; Picornaviridae . In Virus Taxonomy: Classification and Nomenclature of Viruses: Ninth Report of the International Committee on Taxonomy of Viruses pp. 855–880 Edited by King A. M. Q., Adams M. J., Carstens E. B., Lefkowitz E. J. San Diego, CA: Elsevier;
    [Google Scholar]
  8. Lukashev A. N. 2005; Role of recombination in evolution of enteroviruses. Rev Med Virol 15:157–167 [View Article][PubMed]
    [Google Scholar]
  9. Lukashev A. N., Lashkevich V. A., Ivanova O. E., Koroleva G. A., Hinkkanen A. E., Ilonen J. 2005; Recombination in circulating human enterovirus B: independent evolution of structural and non-structural genome regions. J Gen Virol 86:3281–3290 [View Article][PubMed]
    [Google Scholar]
  10. Minor P. D., Ferguson M., Evans D. M., Almond J. W., Icenogle J. P. 1986; Antigenic structure of polioviruses of serotypes 1, 2 and 3. J Gen Virol 67:1283–1291 [View Article][PubMed]
    [Google Scholar]
  11. Oberste M. S., Maher K., Kilpatrick D. R., Flemister M. R., Brown B. A., Pallansch M. A. 1999a; Typing of human enteroviruses by partial sequencing of VP1. J Clin Microbiol 37:1288–1293[PubMed]
    [Google Scholar]
  12. Oberste M. S., Maher K., Kilpatrick D. R., Pallansch M. A. 1999b; Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification. J Virol 73:1941–1948[PubMed]
    [Google Scholar]
  13. Oberste M. S., Peñaranda S., Maher K., Pallansch M. A. 2004; Complete genome sequences of all members of the species human enterovirus A. J Gen Virol 85:1597–1607 [View Article][PubMed]
    [Google Scholar]
  14. Page G. S., Mosser A. G., Hogle J. M., Filman D. J., Rueckert R. R., Chow M. 1988; Three-dimensional structure of poliovirus serotype 1 neutralizing determinants. J Virol 62:1781–1794[PubMed]
    [Google Scholar]
  15. Pallansch M. R., Roos R. 2007; Enteroviruses. In Fields Virology, 5th edn. pp. 839–893 Edited by Knipe D. M., Howley P. M. Philadelphia, PA: Lippincott Williams & Wilkins;
    [Google Scholar]
  16. Pankovics P., Boros A., Szabó H., Székely G., Gyurkovits K., Reuter G. 2012; Human enterovirus 109 (EV109) in acute paediatric respiratory disease in Hungary. Acta Microbiol Immunol Hung 59:285–290 [View Article][PubMed]
    [Google Scholar]
  17. Piralla A., Rovida F., Baldanti F., Gerna G. 2010; Enterovirus genotype EV-104 in humans, Italy, 2008–2009. Emerg Infect Dis 16:1018–1021 [View Article][PubMed]
    [Google Scholar]
  18. Piralla A., Lilleri D., Sarasini A., Marchi A., Zecca M., Stronati M., Baldanti F., Gerna G. 2012; Human rhinovirus and human respiratory enterovirus (EV68 and EV104) infections in hospitalized patients in Italy, 2008–2009. Diagn Microbiol Infect Dis 73:162–167 [View Article][PubMed]
    [Google Scholar]
  19. Racaniello V. 2007; Picornaviridae: the viruses and their replication. In Fields Virology, 5th edn. pp. 795–839 Edited by Knipe D. M., Howley P. M. Philadelphia, PA: Lippincott Williams & Wilkins;
    [Google Scholar]
  20. Razuri H., Romero C., Tinoco Y., Guezala M. C., Ortiz E., Silva M., Reaves E., Williams M., Laguna-Torres V. A. other authors 2012; Population-based active surveillance cohort studies for influenza: lessons from Peru. Bull World Health Organ 90:318–320[PubMed]
    [Google Scholar]
  21. Tamura K. D. J., Dudley J., Nei M., Kumar S. 2007; mega4: Molecular Evolutionary Genetics Analysis (mega) software version 4.0. Mol Biol Evol 24:1596–1599 [View Article][PubMed]
    [Google Scholar]
  22. Tapparel C., Junier T., Gerlach D., Van-Belle S., Turin L., Cordey S., Mühlemann K., Regamey N., Aubert J. D. other authors 2009; New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses. Emerg Infect Dis 15:719–726 [View Article][PubMed]
    [Google Scholar]
  23. Tokarz R., Firth C., Madhi S. A., Howie S. R., Wu W. Y., Sall A. A., Haq S., Briese T., Lipkin W. I. 2012; Worldwide emergence of multiple clades of enterovirus 68. J Gen Virol 93:1952–1958[PubMed] [CrossRef]
    [Google Scholar]
  24. Yozwiak N. L., Skewes-Cox P., Gordon A., Saborio S., Kuan G., Balmaseda A., Ganem D., Harris E., DeRisi J. L. 2010; Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua. J Virol 84:9047–9058 [View Article][PubMed]
    [Google Scholar]
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