Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus
Coleman, Christopher M. and Matthews, Krystal L. and Goicochea, Lindsay and Frieman, Matthew B.,, 95, 408-412 (2014),
doi = https://doi.org/10.1099/vir.0.060640-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50 % lethality in infected individuals. The development of a small-animal model is critical for the understanding of this virus and to aid in development of countermeasures against MERS-CoV. We found that BALB/c, 129/SvEv and 129/SvEv STAT1 knockout mice are not permissive to MERS-CoV infection. The lack of infection may be due to the low level of mRNA and protein for the MERS-CoV receptor, dipeptidyl peptidase 4 (DPP4), in the lungs of mice. The low level of DPP4 in the lungs likely contributes to the lack of viral replication in these mouse models and suggests that a transgenic mouse model expressing DPP4 to higher levels is necessary to create a mouse model for MERS-CoV.,
language=,
type=