RT Journal Article SR Electronic(1) A1 Lobigs, Mario A1 Müllbacher, Arno A1 Wang, Yang A1 Pavy, Megan A1 Lee, EvaYR 2003 T1 Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus JF Journal of General Virology, VO 84 IS 3 SP 567 OP 572 DO https://doi.org/10.1099/vir.0.18654-0 PB Microbiology Society, SN 1465-2099, AB We have investigated the contribution of the interferon (IFN)-α/β system, IFN-γ and nitric oxide to recovery from infection with Murray Valley encephalitis virus, using a mouse model for flaviviral encephalitis where a small dose of virus was administered to 6-week-old wild-type and gene knockout animals by the intravenous route. We show that a defect in the IFN-α/β responses results in uncontrolled extraneural virus growth, rapid virus entry into the brain and 100 % mortality. In contrast, mice deficient in IFN-γ or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.18654-0