1887

Abstract

Infection of laboratory mice by the (MHV-4) is a much studied model system for gammaherpesvirus pathogenesis. Little, however, is known about its natural host range, epidemiology and pathogenesis outside the laboratory. We have studied MHV-4 infection in free-living murids in the UK. Using a combination of serology and PCR analysis, we found that MHV-4 was endemic in wood mice () but not in two species of voles (, ). The sites of detection of viral DNA were the lungs and, less commonly, the spleen, emphasizing the importance of the former in virus persistence during natural infection and confirming similar data in laboratory mice.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.18731-0
2003-01-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/1/vir840111.html?itemId=/content/journal/jgv/10.1099/vir.0.18731-0&mimeType=html&fmt=ahah

References

  1. Begon M., Hazel S. M., Baxby D., Bown K., Cavanagh R., Chantrey J., Jones T., Bennett M. 1999; Transmission dynamics of a zoonotic pathogen within and between wildlife host species. Proc R Soc Lond B Biol Sci 266:1939–1945
    [Google Scholar]
  2. Birtles R. J., Hazel S. M., Bennett M., Bown K., Raoult D., Begon M. 2001; Longitudinal monitoring of the dynamics of infections due to Bartonella species in UK woodland rodents. Epidemiol Infect 126:232–239
    [Google Scholar]
  3. Blaskovic D., Stancekova M., Svobodova J., Mistrikova J. 1980; Isolation of five strains of herpesviruses from two species of free-living small rodents. Acta Virol 24:468
    [Google Scholar]
  4. Chantrey J., Meyer H., Baxby D., Begon M., Bown K. J., Hazel S. M., Jones T., Montgomery W. I., Bennett M. 1999; Cowpox: reservoir hosts and geographic range. Epidemiol Infect 122:455–460
    [Google Scholar]
  5. Crouch A. C., Baxby D., McCracken C. M., Gaskell R. M., Bennett M. 1995; Serological evidence for the reservoir hosts of cowpox virus in British wildlife. Epidemiol Infect 115:185–191
    [Google Scholar]
  6. Efstathiou S., Ho Y. M., Hall S., Styles C. J., Scott S. D., Gompels U. A. 1990; Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein–Barr virus and herpesvirus saimiri. J Gen Virol 71:1365–1372
    [Google Scholar]
  7. Ehtisham S., Sunil-Chandra N. P., Nash A. A. 1993; Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells. J Virol 67:5247–5252
    [Google Scholar]
  8. Flano E., Husain S. M., Sample J. T., Woodland D. L., Blackman M. A. 2000; Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages. J Immunol 165:1074–1081
    [Google Scholar]
  9. Kozuch O., Reichel M., Lesso J., Remenova A., Labuda M., Lysy J., Mistrikova J. 1993; Further isolation of murine herpesviruses from small mammals in southwestern Slovakia. Acta Virol 37:101–105
    [Google Scholar]
  10. Macrae A. I., Dutia B. M., Milligan S., Brownstein D. G., Allen D. J., Mistrikova J., Davison A. J., Nash A. A., Stewart J. P. 2001; Analysis of a novel strain of murine gammaherpesvirus reveals a genomic locus important for acute pathogenesis. J Virol 75:5315–5327
    [Google Scholar]
  11. Mistrikova J., Blaskovic D. 1985; Ecology of the murine alphaherpesvirus and its isolation from lungs of rodents in cell culture. Acta Virol 29:312–317
    [Google Scholar]
  12. Mistrikova J., Remenova A., Lesso J., Stancekova M. 1994; Replication and persistence of murine herpesvirus 72 in lymphatic system and peripheral blood mononuclear cells of Balb/C mice. Acta Virol 38:151–156
    [Google Scholar]
  13. Mistrikova J., Rajcani J., Mrmusova M., Oravcova I. 1996; Chronic infection of Balb/c mice with murine herpesvirus 72 is associated with neoplasm development. Acta Virol 40:297–301
    [Google Scholar]
  14. Nash A. A., Dutia B. M., Stewart J. P., Davison A. J. 2001; Natural history of murine gamma-herpesvirus infection. Philos Trans R Soc Lond B Biol Sci 356:569–579
    [Google Scholar]
  15. Raslova H., Mistrikova J., Kudelova M., Mishal Z., Sarasin A., Blangy D., Berebbi M. 2000; Immunophenotypic study of atypical lymphocytes generated in peripheral blood and spleen of nude mice after MHV-72 infection. Viral Immunol 13:313–327
    [Google Scholar]
  16. Sangster M. Y., Topham D. J., D’Costa S., Cardin R. D., Marion T. N., Myers L. K., Doherty P. C. 2000; Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus. J Immunol 164:1820–1828
    [Google Scholar]
  17. Stewart J. P. 1999; Of mice and men: murine gammaherpesvirus 68 as a model. Epstein–Barr Virus Report 6:31–35
    [Google Scholar]
  18. Stewart J. P., Usherwood E. J., Ross A., Dyson H., Nash T. 1998; Lung epithelial cells are a major site of murine gammaherpesvirus persistence. J Exp Med 187:1941–1951
    [Google Scholar]
  19. Sunil-Chandra N. P., Efstathiou S., Arno J., Nash A. A. 1992a; Virological and pathological features of mice infected with murine gammaherpesvirus 68. J Gen Virol 73:2347–2356
    [Google Scholar]
  20. Sunil-Chandra N. P., Efstathiou S., Nash A. A. 1992b; Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo . J Gen Virol 73:3275–3279
    [Google Scholar]
  21. Telfer S., Bennett M., Bown K. J., Cavanagh R., Crespin L., Hazel S., Jones T., Begon M. 2002; The effects of cowpox on survival in natural rodent populations: increases and decreases. J Animal Ecology 71:558–568
    [Google Scholar]
  22. Usherwood E. J., Stewart J. P., Robertson K., Allen D. J., Nash A. A. 1996; Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice. J Gen Virol 77:2819–2825
    [Google Scholar]
  23. Usherwood E. J., Roy D. J., Ward K., Surman S. L., Dutia B. M., Blackman M. A., Stewart J. P., Woodland D. L. 2000; Control of gammaherpesvirus latency by latent antigen-specific CD8+ T cells. J Exp Med 192:943–952
    [Google Scholar]
  24. Virgin H. W. IV, Latreille P., Wamsley P., Hallsworth K., Weck K. E., Dal Canto A. J., Speck S. H. 1997; Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol 71:5894–5904
    [Google Scholar]
  25. Weck K. E., Kim S. S., Virgin H. W. IV., Speck S. H. 1999; Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells. J Virol 73:3273–3283
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.18731-0
Loading
/content/journal/jgv/10.1099/vir.0.18731-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error