RT Journal Article SR Electronic(1) A1 Wiebusch, Lüder A1 Truss, Matthias A1 Hagemeier, ChristianYR 2004 T1 Inhibition of human cytomegalovirus replication by small interfering RNAs JF Journal of General Virology, VO 85 IS 1 SP 179 OP 184 DO https://doi.org/10.1099/vir.0.19453-0 PB Microbiology Society, SN 1465-2099, AB Small interfering RNAs (siRNAs) are the mediators of a sequence-specific process of gene silencing called RNA interference (RNAi). Here, we show that synthetic siRNAs against essential gene products of human cytomegalovirus (HCMV) can trigger RNAi in serum-starved, infected primary fibroblasts, as well as in U373 cells, leading to effective inhibition of viral DNA replication. This opens new possibilities for antiviral strategies and for the analysis of viral and cellular genes important to HCMV physiology., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19453-0