Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae
Waltzek, Thomas B. and Kelley, Garry O. and Stone, David M. and Way, Keith and Hanson, Larry and Fukuda, Hideo and Hirono, Ikuo and Aoki, Takashi and Davison, Andrew J. and Hedrick, Ronald P.,, 86, 1659-1667 (2005),
doi = https://doi.org/10.1099/vir.0.80982-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= The sequences of four complete genes were analysed in order to determine the relatedness of koi herpesvirus (KHV) to three fish viruses in the family Herpesviridae: carp pox herpesvirus (Cyprinid herpesvirus 1, CyHV-1), haematopoietic necrosis herpesvirus of goldfish (Cyprinid herpesvirus 2, CyHV-2) and channel catfish virus (Ictalurid herpesvirus 1, IcHV-1). The genes were predicted to encode a helicase, an intercapsomeric triplex protein, the DNA polymerase and the major capsid protein. The results showed that KHV is related closely to CyHV-1 and CyHV-2, and that the three cyprinid viruses are related, albeit more distantly, to IcHV-1. Twelve KHV isolates from four diverse geographical areas yielded identical sequences for a region of the DNA polymerase gene. These findings, with previously published morphological and biological data, indicate that KHV should join the group of related lower-vertebrate viruses in the family Herpesviridae under the formal designation Cyprinid herpesvirus 3 (CyHV-3).,
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