Cell target genes of Epstein–Barr virus transcription factor EBNA-2: induction of the p55α regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells

References

1. Ali K., Bilancio A., Thomas M. & 14 other authors 2004; Essential role for the p110 δ phosphoinositide 3-kinase in the allergic response. Nature 431:1007–1011 [CrossRef]
   [Google Scholar]
2. Brennan P., Mehl A. M., Jones M., Rowe M. 2002; Phosphatidylinositol 3-kinase is essential for the proliferation of lymphoblastoid cells. Oncogene 21:1263–1271 [CrossRef]
   [Google Scholar]
3. Castoria G., Migliaccio A., Bilancio A. & 7 other authors 2001; PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J 20:6050–6059 [CrossRef]
   [Google Scholar]
4. Dawson C. W., Tramountanis G., Eliopoulos A. G., Young L. S. 2003; Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem 278:3694–3704 [CrossRef]
   [Google Scholar]
5. End P., Gout I., Fry M. J., Panayotou G., Dhand R., Yonezawa K., Kasuga M., Waterfield M. D. 1993; A biosensor approach to probe the structure and function of the p85 α subunit of the phosphatidylinositol 3-kinase complex. J Biol Chem 268:10066–10075
   [Google Scholar]
6. Fruman D. A., Snapper S. B., Yballe C. M., Alt F. W., Cantley L. C. 1999a; Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans 27:624–629
   [Google Scholar]
7. Fruman D. A., Snapper S. B., Yballe C. M., Davidson L., Yu J. Y., Alt F. W., Cantley L. C. 1999b; Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85 α . Science 283:393–397 [CrossRef]
   [Google Scholar]
8. Fukuda M., Longnecker R. 2004; Latent membrane protein 2A inhibits transforming growth factor- β 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. J Virol 78:1697–1705 [CrossRef]
   [Google Scholar]
9. Gout I., Dhand R., Hiles I. D. & 9 other authors 1993; The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell 75:25–36 [CrossRef]
   [Google Scholar]
10. Inukai K., Anai M., Van Breda E. & 9 other authors 1996; A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85 α gene. J Biol Chem 271:5317–5320 [CrossRef]
    [Google Scholar]
11. Inukai K., Funaki M., Ogihara T. & 12 other authors 1997; p85 α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50 α , p55 α , and p85 α , with different PI 3-kinase activity elevating responses to insulin. J Biol Chem 272:7873–7882 [CrossRef]
    [Google Scholar]
12. Inukai K., Funaki M., Nawano M. & 10 other authors 2000; The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin. Biochem J 346:483–489 [CrossRef]
    [Google Scholar]
13. Inukai K., Funaki M., Anai M. & 11 other authors 2001; Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations. FEBS Lett 490:32–38 [CrossRef]
    [Google Scholar]
14. Kaiser C., Laux G., Eick D., Jochner N., Bornkamm G. W., Kempkes B. 1999; The proto-oncogene c- myc is a direct target gene of Epstein-Barr virus nuclear antigen 2. J Virol 73:4481–4484
    [Google Scholar]
15. Kempkes B., Spitkovsky D., Jansen-Durr P., Ellwart J. W., Kremmer E., Delecluse H. J., Rottenberger C., Bornkamm G. W., Hammerschmidt W. 1995; B-cell proliferation and induction of early G₁-regulating proteins by Epstein–Barr virus mutants conditional for EBNA2. EMBO J 14:88–96
    [Google Scholar]
16. Kieff E., Rickinson A. B. 2001; Epstein-Barr virus and its replication. In Fields Virology , 4th edn. pp  2511–2573 Edited by Knipe D. M., Howley P. M. Philadelphia, PA: Lippincott Williams & Wilkins;
    [Google Scholar]
17. Mann K. P., Staunton D., Thorley-Lawson D. A. 1985; Epstein-Barr virus-encoded protein found in plasma membrane in transformed cells. J Virol 55:710–720
    [Google Scholar]
18. Okada T., Maeda A., Iwamatsu A., Gotoh K., Kurosaki T. 2000; BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 13:817–827 [CrossRef]
    [Google Scholar]
19. Okamoto T., Namikawa K., Asano T., Takaoka K., Kiyama H. 2004; Differential regulation of the regulatory subunits for phosphatidylinositol 3-kinase in response to motor nerve injury. Brain Res Mol Brain Res 131:119–125 [CrossRef]
    [Google Scholar]
20. Okkenhaug K., Vanhaesebroeck B. 2003; PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 3:317–330 [CrossRef]
    [Google Scholar]
21. Portis T., Longnecker R. 2004; Epstein–Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway. Oncogene 23:8619–8628 [CrossRef]
    [Google Scholar]
22. Raftopoulou M., Hall A. 2004; Cell migration: Rho GTPases lead the way. Dev Biol 265:23–32 [CrossRef]
    [Google Scholar]
23. Scholle F., Bendt K. M., Raab-Traub N. 2000; Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt. J Virol 74:10681–10689 [CrossRef]
    [Google Scholar]
24. Sinclair A. J., Farrell P. J. 1995; Host cell requirements for efficient infection of quiescent primary B lymphocytes by Epstein-Barr virus. J Virol 69:5461–5468
    [Google Scholar]
25. Spender L. C., Cornish G. H., Sullivan A., Farrell P. J. 2002; Expression of transcription factor AML-2 (RUNX3, CBF α -3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype. J Virol 76:4919–4927 [CrossRef]
    [Google Scholar]
26. Spender L. C., Whiteman H. J., Karstegl C. E., Farrell P. J. 2005; Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells. Oncogene 24:1873–1881 [CrossRef]
    [Google Scholar]
27. Swart R., Ruf I. K., Sample J., Longnecker R. 2000; Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-kinase/Akt pathway. J Virol 74:10838–10845 [CrossRef]
    [Google Scholar]
28. Terauchi Y., Tsuji Y., Satoh S. & 30 other authors 1999; Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 α subunit of phosphoinositide 3-kinase. Nat Genet 21:230–235 [CrossRef]
    [Google Scholar]
29. Tsai E.-M., Wang S.-C., Lee J.-N., Hung M.-C. 2001; Akt activation by estrogen in estrogen receptor-negative breast cancer cells. Cancer Res 61:8390–8392
    [Google Scholar]
30. Ueki K., Algenstaedt P., Mauvais-Jarvis F., Kahn C. R. 2000; Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85 α regulatory subunit. Mol Cell Biol 20:8035–8046 [CrossRef]
    [Google Scholar]
31. Ueki K., Fruman D. A., Brachmann S. M., Tseng Y.-H., Cantley L. C., Kahn C. R. 2002; Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol 22:965–977 [CrossRef]
    [Google Scholar]
32. Wilkinson S., Paterson H. F., Marshall C. J. 2005; Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol 7:255–261 [CrossRef]
    [Google Scholar]
33. Zhao B., Maruo S., Cooper A., Chase M. R., Johannsen E., Kieff E., Cahir-McFarland E. 2006; RNAs induced by Epstein–Barr virus nuclear antigen 2 in lymphoblastoid cell lines. Proc Natl Acad Sci U S A 103:1900–1905 [CrossRef]
    [Google Scholar]