@article{mbs:/content/journal/micro/10.1099/mic.0.000601, author = "Gordon, Stephen V. and Parish, Tanya", title = "Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe", journal= "Microbiology", year = "2018", volume = "164", number = "4", pages = "437-439", doi = "https://doi.org/10.1099/mic.0.000601", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000601", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Mycobacterium tuberculosis is an expert and deadly pathogen, causing the disease tuberculosis (TB) in humans. It has several notable features: the ability to enter non-replicating states for long periods and cause latent infection; metabolic remodelling during chronic infection; a thick, waxy cell wall; slow growth rate in culture; and intrinsic drug resistance and antibiotic tolerance. As a pathogen, M. tuberculosis has a complex relationship with its host, is able to replicate inside macrophages, and expresses diverse immunomodulatory molecules. M. tuberculosis currently causes over 1.8 million deaths a year, making it the world’s most deadly human pathogen.", }