1887

Abstract

The transmissible agent of scrapie has not yet been characterized but it is commonly referred to as a virus (Andrewes & Pereira, 1967). However, on the basis of its resistance to acetylethyleneimine, Stamp . (1959) suggested that the agent might not contain nucleoprotein. Pattison (1965), reporting on the effect of formalin, expressed the opinion that the agent might not be a virus and now believes it to be, or to be associated with, a small basic protein (Pattison & Jones, 1967). In a study of the effect of ionizing and ultraviolet irradiation Alper, Haig & Clarke (1966) and Alper . (1967) suggested that the agent may lack nucleic acid. On the basis of these results and the inactivation of the scrapie agent with urea and phenol, Gibbons & Hunter (1967) have proposed a membrane hypothesis for its nature. Other workers (e.g. Adams & Caspary, 1967) still believe that the agent is essentially viral in character.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-3-2-281
1968-09-01
2024-05-04
Loading full text...

Full text loading...

/deliver/fulltext/jgv/3/2/JV0030020281.html?itemId=/content/journal/jgv/10.1099/0022-1317-3-2-281&mimeType=html&fmt=ahah

References

  1. Adams D. H., Caspary E. A. 1967; Nature of the scrapie virus. Br. med. J. 3:173
    [Google Scholar]
  2. Alper T., Haig D. A., Clarke M. C. 1966; The exceptionally small size of the scrapie agent. Biochem. biophys. Res. Commun 22:278
    [Google Scholar]
  3. Alper T., Cramp W. A., Haig D. A., Clarke M. C. 1967; Does the scrapie agent replicate without nucleic acid?. Nature, Lond 214:764
    [Google Scholar]
  4. Andrewes C. H., Pereira H. G. 1967 In Viruses of Vertebrates London: Baillière, Tindall and Cassell;
    [Google Scholar]
  5. Brown F., Cartwright B. 1960; Purification of the virus of foot-and-mouth disease by fluorocarbon treatment and its dissociation from neutralizing antibody. J. Immun 85:309
    [Google Scholar]
  6. Chandler R. L. 1961; Encephalopathy in mice produced by inoculation with scrapie brain material. Lancet 1:1378
    [Google Scholar]
  7. Gibbons R. A., Hunter G. D. 1967; Nature of the scrapie agent. Nature, Lond 215:1041
    [Google Scholar]
  8. Kärber G. 1931; Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Arch, exp. Path. Pharmak 162:480
    [Google Scholar]
  9. LoGrippo G. A. 1959; Investigations of the use of beta-propiolactone in virus inactivation. Ann. N. Y. Acad. Sci 83:578
    [Google Scholar]
  10. LoGrippo G. A., Hartman F. H. 1955; Antigenicity of β-propiolactone-inactivated virus vaccines. J. Immun 75:123
    [Google Scholar]
  11. Newton A., Waterson A. P. 1967; Physical and chemical properties of viruses. In Viral and Rickettsial Infections of Animals ch 2 p 27 Ed. by Betts O. A., York C. J. New York and Lond or: Academic Press;
    [Google Scholar]
  12. Pattison I. H. 1965; Resistance of the scrapie agent to formalin. J. comp. Path. Ther 75:159
    [Google Scholar]
  13. Pattison I. H., Jones K. M. 1967; The possible nature of the transmissible agent of scrapie. Vet. Rec 80:2
    [Google Scholar]
  14. Stamp J. T., Brotherston J. G., Zlotnik I., Mackay J. M. K., Smith W. 1959; Further studies on scrapie. J. comp. Path. Ther 69:268
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-3-2-281
Loading
/content/journal/jgv/10.1099/0022-1317-3-2-281
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error