1887

Abstract

SUMMARY

Tilorone hydrochloride, at a concentration of 10 µg/ml inhibits the growth of herpes simplex virus type 1 in BS-C-1 cells. The growth of vaccinia virus in BS-C-1 cells is partially inhibited; however, six viruses containing RNA, including four members of the togavirus group grown in chick fibroblasts, are not affected by the drug. The inhibition of the growth of herpes virus by tilorone hydrochloride is greater when the multiplicity of infection is lower than 1 p.f.u./cell and when the drug is added early in the course of infection.

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/content/journal/jgv/10.1099/0022-1317-31-1-125
1976-04-01
2024-05-06
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References

  1. ADAMSON R. H. 1971; Antitumor activity of tilorone hydrochloride against some rodent tumors: preliminary report. Journal of the National Cancer Institute 46:431–434
    [Google Scholar]
  2. ANDREWS E. R., FLEMING R. W., GRISAR J. M., KIHM J. C, WENSTRUP D. L., MAYER G. D. 1974; BlS-baSlC substituted polycyclic aromatic compounds. A new class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol and fluorene. Journal of Medicinal Chemistry 17:882–886
    [Google Scholar]
  3. BARKER A. D., RHEINS M. S., WILSON H. E. 1971; Amelioration of Friend virus leukemia by sequential administration of viral and nonviral interferon inducers. Proceedings of the Society for Experimental Biology and Medicine 137:981–987
    [Google Scholar]
  4. CHANDRA P., ZUNINO F., GöTZ A. 1972; Bis DEAE fluorenone (tilorone): a specific inhibitor of DNA polymerases from RNA tumor viruses. FEBS letters 22:161–164
    [Google Scholar]
  5. DECLERCQ E., MERIGAN T. C. 1971; Bis-DEAE fluorene: mechanism of antiviral protection and stimulation of interferon production in the mouse. Journal of Infectious Diseases 123:190–199
    [Google Scholar]
  6. GIRON D. J., SCHMIDT J. P., PINDAK F. F. 1972; Tilorone HCl: lack of correlation between interferon induction and viral protection. Antimicrobial Agents and Chemotherapy 1:78–79
    [Google Scholar]
  7. KRUEGER R. F., MAYER G. D. 1970; Tilorone hydrochloride: an orally active antiviral agent. Science, New York 169:1213–1214
    [Google Scholar]
  8. MAYER G. D., KRUEGER R. F. 1970; Tilorone hydrochloride: mode of action. Science, New York 169:1214–1215
    [Google Scholar]
  9. MUNSON A. E., MUNSON J. A., REGELSON W., WAMPLER G. L. 1972; Effect of tilorone hydrochloride and congeners on reticulo-endothelial system, tumors and the immune response. Cancer Research 32:1397–1403
    [Google Scholar]
  10. ROYE D., RHOADS A., MORRIS H. P., WEST W. L. 1971; Effect of Bis DEAE fluorenone (tilorone) on growth of tumors in rats. Pharmacologist 13:260
    [Google Scholar]
  11. STRINGFELLOW D. A., GLASGOW L. A. 1972; Tilorone HCl: an oral interferon inducing agent. Antimicrobial Agents and Chemotherapy 2:73–78
    [Google Scholar]
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