1887

Abstract

SUMMARY

Multiplication of the human clonal cell line, RSa, is completely inhibited by human leukocyte interferon preparations. Synthesis of DNA and protein is markedly reduced in these cells in proportion to the concentration of interferon applied. Interferon treatment leads to accumulation of cells of an epithelial morphology which do not enter the division cycle. It is suggested that the growth inhibitory effects of interferon on RSa cells may result from these effects.

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1976-10-01
2024-05-04
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References

  1. Adams A., Strander H., Cantell K. 1975; Sensitivity of Epstein–Barr virus transformed human lymphoid cell lines to interferon. Journal of General Virology 28:207–217
    [Google Scholar]
  2. Brouty-Boyé D., Macieira-Coelho A., Fiszman M., Gresser T. 1973; Interferon and cell division. VIII. Effect of interferon on macromolecular synthesis in L1210 cells in vitro. International Journal of Cancer 12:250–258
    [Google Scholar]
  3. Cantell K. 1970; Attempts to prepare interferon in continuous cultures of human leukocytes. Annals of the New York Academy of Sciences 173:160–168
    [Google Scholar]
  4. Gaffney E. V., Picciano P. T., Grant C. A. 1973; Inhibition of growth and transformation of human cells by interferon. Journal of the National Cancer Institute 50:871–878
    [Google Scholar]
  5. Gresser I. 1961; Metamorphosis of human amnion cells induced by preparations of interferon. Proceedings of the National Academy of Sciences of United States of America 47:1817–1822
    [Google Scholar]
  6. Gresser I. 1972; Antitumor effects of interferon. Advances in Cancer Research 16:97–140
    [Google Scholar]
  7. Johnson T. C., Lerner M. P., Lancz G. J. 1968; Inhibition of protein synthesis in noninfected L cells by partially purified interferon preparations. Journal of Cell Biology 36:617–624
    [Google Scholar]
  8. Kuwata T., Oda T., Sekiya S., Morinaga N. 1976a; Characteristics of a human cell line successively transformed by Rous sarcoma virus and simian virus 40. Journal of the National Cancer Institute 56:919–926
    [Google Scholar]
  9. Kuwata T., Fuse A., Morinaga N. 1976b; Effects of interferon upon cell and virus growth in transformed human cell lines. Journal of General Virology 33:7–15
    [Google Scholar]
  10. Lee S. H. S., O’shaughnessy M. V., Rozee K. R. 1972; Interferon induced growth depression in diploid and heteroploid human cells. Proceedings of the Society for Experimental Biology and Medicine 139:1438–1440
    [Google Scholar]
  11. Lowry O. H., Rosebrough N. J., Farr A. L., Randall A. J. 1951; Protein measurement with the folin phenol reagent. Journal of Biochemistry 193:265–275
    [Google Scholar]
  12. Macieira-Coelho A., Brouty-Boyé D., Thomas M. T., Gresser I. 1971; Interferon and cell division. III. Effect of interferon on the division cycle of L1210 cells, in vitro. Journal of Cell Biology 48:415–419
    [Google Scholar]
  13. O’shaughnessy M. V., Lee S. H. S., Rozee K. R. 1972; Interferon inhibition of DNA synthesis and cell division. Canadian Journal of Microbiology 18:145–151
    [Google Scholar]
  14. O’shaughnessy M. V., Easterbrook K. B., Lee S. H. S., Rozee K. R. 1974; Interferon inhibition of autogenously induced virions (C particles) in synchronized L-929 cell cultures. Journal of the National Cancer Institute 53:1687–1690
    [Google Scholar]
  15. Oxman M. N. 1973; Interferon, tumors and tumor viruses. In Interferons and Interferon Inducers pp 391–480 Edited by Finter N. B. Amsterdam: North Holland Publishing Company;
    [Google Scholar]
  16. Paucker K., Cantell K., Henle W. 1962; Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells. Virology 17:324–334
    [Google Scholar]
  17. Revel M., Content J., Zilberstein A., Berissi H., Lebleu B., Falcoff E., Falcoff R. 1975; Mechanism of the interferon-induced block of mRNA translation in mouse L cells. In Effects of Interferon on Cells, Viruses and the Immune System pp 523–547 Edited by Geraldes A. New York: Academic Press;
    [Google Scholar]
  18. Tovey M., Brouty-Boye D., Gresser I. 1975; Early effect of interferon on mouse leukemia cells cultivated in a chemostat. Proceedings of the National Academy of Sciences of United States of America 72:2265–2269
    [Google Scholar]
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