1887

Abstract

SUMMARY

Various cell lines persistently infected with para-influenza 1 virus, HVJ strain, were less susceptible to the antiviral action of interferon than the same cell lines when not infected with HVJ. When Vero cells persistently infected with a temperature-sensitive strain of HVJ were incubated at 38 °C, a non-permissive temperature, they became fully susceptible to interferon, whereas neither the haemadsorbing nor the cell-associated haemagglutinating activity of the virus was expressed. These findings suggest that the lowered interferon susceptibility of virus-carrier cells may be related to the maturation of virus in them.

It was found that the low susceptibility of virus-carrier cells to interferon is not due to blocked adsorption of interferon or to inability of the cells to respond to interferon. Studies with actinomycin D suggest that some step (or steps) before the synthesis of the messenger RNA for the antiviral protein is blocked.

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1979-04-01
2024-04-28
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References

  1. Chany C., Brailovsky C. 1967; Stimulating interaction between viruses (stimulons). Proceedings of the National Academy of Sciences of the United States of America 57:87–94
    [Google Scholar]
  2. Diderholm H., Dinter Z. 1966; Interference between strains of bovine diarrhoea virus and their capacity to suppress interferon of a heterologous virus. Proceedings of the Society for Experimental Biology and Medicine 121:976–980
    [Google Scholar]
  3. Frothingham T. E. 1965; Further observations on cell cultures infected concurrently with mumps and sindbis viruses. Journal of Immunology 94:521–529
    [Google Scholar]
  4. Ghendon S. N., Balandin I. G., Barushkina L. M. 1966; On the mechanism of the ability of certain viruses to block the action of interferon. Acta Virologica 10:268–270
    [Google Scholar]
  5. Hermodsson S. 1963; Inhibition of interferon by an infection with parainfluenza virus type 3 (PIV-3). Virology 20:333–343
    [Google Scholar]
  6. Ito Y., Kimura Y., Nagata I., Kunii A. 1974; Production of interferon-like substance by mouse spleen cells through contact with BHK cells persistently infected with HVJ. Virology 60:73–84
    [Google Scholar]
  7. Libíková H. 1965; Lowered susceptibility to exogenous interferon during the first stages of virus infection of cells. Acta Virologica 9:279–281
    [Google Scholar]
  8. Lockart R. Z. 1964; The necessity for cellular RNA and protein for viral inhibition resulting from interferon. Biochemical and Biophysical Research Communication 14:447–451
    [Google Scholar]
  9. Maeno K., Yoshii S., Nagata I., Matsumoto T. 1966; Growth of Newcastle disease virus in a HVJ carrier culture of HeLa cells. Virology 29:255–263
    [Google Scholar]
  10. Nagata I., Kimura Y., Ito Y., Tanaka T. 1972; Temperature-sensitive phenomenon of viral maturation observed in BHK cells persistently infected with HVJ. Virology 49:453–461
    [Google Scholar]
  11. Nishiyama Y., Ito Y., Shimokata K., Kimura Y., Nagata I. 1976; Relationship between establishment of persistent infection of haemagglutinating virus of Japan and the properties of the virus. Journal of General Virology 32:73–83
    [Google Scholar]
  12. Preble O. T., Youngner J. S. 1975; Temperature-sensitive viruses and the etiology of chronic and inapparent infections. Journal of Infectious Disease 131:467–473
    [Google Scholar]
  13. Taylor J. 1964; Inhibition of interferon action by actinomycin. Biochemical and Biophysical Research Communications 14:447–451
    [Google Scholar]
  14. Valle M., Cantell K. 1965; The ability of Sendai virus to overcome cellular resistance to vesicular stomatitis virus, I. Annales Medicinae Experimentalis et Biologiae Fenniae 43:57–60
    [Google Scholar]
  15. Vilček J. 1969 In Interferon New York: Springer-Verlag;
    [Google Scholar]
  16. Vilček J., Stanček D. 1963; Unresponsiveness to the action of interferon developed in persistently infected L cells. Life Science 2:895–901
    [Google Scholar]
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