1887

Abstract

SUMMARY

The ability of spleen macrophages to support Friend leukaemia virus replication was studied by testing for infectivity in adherent cells obtained from mice at various times after infection. Virus-releasing macrophages appeared early after infection and reached a high proportion. The released virus was probably synthesized since macrophage infectivity was strongly reduced by treatments which affected cellular viability or synthetic activities and electron microscopy showed C-type particles budding from macrophages.

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1980-07-01
2024-04-27
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References

  1. Allison A. C., Harington J. S., Birbeck M. 1966; An examination of the cytotoxic effects of silica on macrophages. Journal of Experimental Medicine 124:141–154
    [Google Scholar]
  2. Bassin R. N., Tuttle M., Fischinger P. J. 1971; Rapid cell culture assay technique for murine leukaemia viruses. Nature, London 229:564–566
    [Google Scholar]
  3. Bendinelli M., Nardini L. 1973; Immunodepression by Rowson-Parr virus in mice. I. Growth curves of Rowson-Parr virus and immunological relationships with Friend virus. Infection and Immunity 7:152–159
    [Google Scholar]
  4. Bendinelli M., Kaplan G. S., Friedman H. 1975; Reversal of leukemia virus-induced immunosuppression in vitro by peritoneal macrophages. Journal of the National Cancer Institute 55:1425–1432
    [Google Scholar]
  5. Bendinelli M., Matteucci D., Toniolo A., Friedman H. 1979; Macrophage involvement in leukemia virus-induced tumorigenesis. In Advances in Experimental Medicine and Biology vol 121B pp 493–508 Edited by Escobar M. R., Friedman H. New York: Plenum Press;
    [Google Scholar]
  6. Cerny J., Hensgen P. A., Fistel S. H., Demler L. M. 1976; Interactions of murine leukaemia virus with isolated lymphocytes. II. Infection of B and T cells with Friend virus complex in diffusion chambers and in vitro: effect of polyclonal mitogens. International Journal of Cancer 18:189–196
    [Google Scholar]
  7. Chesebro B., Wehrly K., Watson K., Chesebro K. 1978; Murine leukemia virus infectious centers are dependent on the rate of virus production by infected cells. Virology 84:222–226
    [Google Scholar]
  8. Friend C., Scher W., Holland J. G., Sato T. 1971; Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide. Proceedings of the National Academy of Sciences of the United States of America 68:372–382
    [Google Scholar]
  9. Golde D. W., Bersch N., Friend C., Tsuei D., Marovitz W. 1979; Transformation of DBA/2 mouse fetal liver cells infected in vitro by the anemic strain of Friend leukemia virus. Proceedings of the National Academy of Sciences of the United States of America 76:962–966
    [Google Scholar]
  10. Levy M. H., Wheelock E. F. 1975; Impaired macrophage function in Friend virus leukemia: restoration by statolon. Journal of Immunology 114:962–965
    [Google Scholar]
  11. Marcelletti J., Furmanski P. 1978; Spontaneous regression of Friend virus-induced erythroleukemia. III. The role of macrophages in regression. Journal of Immunology 120:1–8
    [Google Scholar]
  12. Marcelletti J., Furmanski P. 1979; Infection of macrophages with Friend virus: relationship to the spontaneous regression of viral erythroleukemia. Cell 16:649–659
    [Google Scholar]
  13. Mosier D. E. 1967; A requirement for two cell types for antibody formation in vitro. Science 158:1573–1575
    [Google Scholar]
  14. Odaka T., Kohler K. 1965; Über aufnahme und vermehrung des Friend-leukamie-virus in makrophagen. Zeitschrift für Naturforschung 20 b:473–476
    [Google Scholar]
  15. Specter S. C., Bendinelli M., Ceglowski W. S., Friedman H. 1978; Macrophage-induced reversal of immunosuppression by leukemia viruses. Federation Proceedings 37:97–101
    [Google Scholar]
  16. Tambourin P. E., Wemdling F. 1975; Target cells for oncogenic action of polycythaemia-inducing Friend virus. Nature, London 256:320–322
    [Google Scholar]
  17. Tambourin P. E., Wendling F., Jasmin C., Smadja-Joffe F. 1979; The physiopathology of Friend leukaemia. Leukaemia Research 3:117–129
    [Google Scholar]
  18. Yokochi T., Nakashima I., Kato N. 1979; Further studies on generation of macrophages in in vitro cultures of mouse spleen cells and its inhibition by the capsular polysaccharide of Klebsiella pneumoniae. Microbiology and Immunology 23:487–499
    [Google Scholar]
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