1887

Abstract

SUMMARY

Temperature-sensitive () mutations occurring in three genes 1, 2 and 7, and 1, 5 and 7 were found in two cold-adapted () attenuated influenza virus strains A/Leningrad/9/37/46 (H0N1) and A/Leningrad/134/17/57 (H2N2) respectively. The recombinants, obtained by crossing these cold-adapted strains with virulent influenza virus strains, had different genome structures and inherited from one to six genes from the cold-adapted parents. Tests of reactogenicity of recombinants in volunteers showed all the recombinants to be non-reactogenic irrespective of the number of genes inherited from the cold-adapted parent.

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1981-04-01
2024-05-04
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