f Either Orientation of the L Segment of the Herpes Simplex Virus Genome May Participate in the Production of Viable Intertypic Recombinants
- Authors: A. J. Davison, N. M. Wilkie†
- First Published Online: 01 January 1983, Journal of General Virology 64: 247-250, doi: 10.1099/0022-1317-64-1-247
- Subject: Animal
- Issue Published:
We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation.
Present address: The Beatson Institute for Cancer Research, Wolfson Laboratory for Molecular Pathology, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K.
© Society for General Microbiology 1983 | Published by the Microbiology Society
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