1887

Abstract

SUMMARY

Treatment of bovine alveolar macrophages (BAM) with bovine leukocyte interferon (BoIFN-α) resulted in reduced bovine herpesvirus type 1 replication and spread. This was demonstrated by reduced virus yields and number of cells infected. BoIFN-α treatment of BAM also induced enhanced Fc receptor expression and/or avidity by the cells, increased their activity in antibody-dependent cellular cytotoxicity, and augmented their extrinsic antiviral activity as measured by a reduction in the development of plaques in a susceptible cell line. These results are discussed in the context of the possible role of interferon in activation of AM during the early phases of a virus infection.

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1984-09-01
2024-04-27
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References

  1. Babiuk L. A., Bielefeldt Ohmann H. 1984; Effect of levamisole and bovine interferon-α1 on bovine immune responses and susceptibility to bovine herpesvirus-1. In Chemical Regulation of Immunity in Veterinary Medicine pp 433–442 Edited by Gainer J. H. New York: Alan R. Liss;
    [Google Scholar]
  2. Babiuk L. A., Rouse B. T. 1976; Immune interferon production by lymphoid cells: role in the inhibition of herpesviruses. Infection and Immunity 13:1567–1578
    [Google Scholar]
  3. Babiuk L. A., Rouse B. T. 1978; Interactions between effector cell activity and lymphokines: implications for recovery from herpesvirus infections. International Archives of Allergy and Applied Immunology 57:62–73
    [Google Scholar]
  4. Bell D. M., Roberts N. J., Hall C. B. 1983; Different antiviral spectra of human macrophage interferon activities. Nature, London 305:319–321
    [Google Scholar]
  5. Bielefeldt Ohmann H., Babiuk L. A. 1984; Effect of bovine recombinant-α1 interferon on inflammatory responses of bovine phagocytes. Journal of Interferon Research 4:249–263
    [Google Scholar]
  6. Blanden R. V., Hapel A. J., Doherty P. C., Zinkernagel R. M. 1976; Lymphocyte-macrophage interactions and macrophage activation in the expression of antimicrobial immunity in vivo. In Immunobiology of the Macrophage pp 367–400 Edited by Nelson D. S. New York: Academic Press;
    [Google Scholar]
  7. Demaeyer E., Demaeyer-Guignard J. 1982; Immuno-modulating properties of interferons. Philosophical Transactions of the Royal Society of London B 299:77–90
    [Google Scholar]
  8. Forman A. J., Babiuk L. A. 1982; Effect of infectious rhinotracheitis virus infection on bovine alveolar macrophage function. Infection and Immunity 35:1041–1047
    [Google Scholar]
  9. Forman A. J., Babiuk L. A., Baldwin F., Friend S. C. E. 1982a; Effect of infectious bovine rhinotracheitis virus infection of calves on cell populations recovered by lung lavage. American Journal of Veterinary Research 43:1174–1179
    [Google Scholar]
  10. Forman A. J., Babiuk L. A., Misra V., Baldwin F. 1982b; Susceptibility of bovine macrophages to infectious bovine rhinotracheitis virus infection. Infection and Immunity 35:1048–1057
    [Google Scholar]
  11. Grewal A. S., Rouse B. T., Babiuk L. A. 1978; Characterization of surface receptors on bovine leukocytes. International Archives of Allergy and Applied Immunology 56:289–300
    [Google Scholar]
  12. Haller O., Arnheiter H., Lindenmann J., Gresser I. 1980; Host gene influences sensitivity to interferon action selectively for influenza virus. Nature, London 283:660–662
    [Google Scholar]
  13. Hayashi K., Kurata T., Morishima T., Nassery T. 1980; Analysis of the inhibitory effect of peritoneal macrophages on the spread of herpes simplex virus. Infection and Immunity 28:350–358
    [Google Scholar]
  14. Keller R. 1976; Cytostatic and cytocidal effects of activated macrophages. In Immunobiology of the Macrophage pp 487–508 Edited by Nelson D. S. New York: Academic Press;
    [Google Scholar]
  15. Loosli C. G. 1973; Influenza and the interaction of viruses and bacteria in respiratory infections. Medicine 52:369–384
    [Google Scholar]
  16. Lyons C. R., Lipscomb M. F. 1983; Alveolar macrophages in pulmonary immune responses. I. Role in the initiation of primary immune responses and in the selective recruitment of T lymphocytes to the lung. Journal of Immunology 130:1113–1119
    [Google Scholar]
  17. Mcguire R., Babiuk L. A. 1982; In vitro culture characteristics of bovine alveolar macrophages. Journal of the Reticuloendothelial Society 31:251–260
    [Google Scholar]
  18. Maehara N., Ho M., Armstrong J. A. 1977; Differences in mouse interferons according to cell source and mode of induction. Infection and Immunity 17:572–579
    [Google Scholar]
  19. Misra V., Blumenthal R. M., Babiuk L. A. 1981; Proteins specified by bovine herpesvirus 1 (infectious bovine rhinotracheitis virus). Journal of Virology 40:367–378
    [Google Scholar]
  20. Misra V., Gilchrist J. E., Weinmaster G., Qualtiere L., Van Den Hurk S., Babiuk L. A. 1982; HerpeSvirUS-induced ‘early’ glycoprotein: characterization and possible role in immune cytolysis. Journal of Virology 43:1046–1054
    [Google Scholar]
  21. Morahan P. S., Morse S. S. 1979; Macrophage-virus interactions. In Virus-Lymphocyte Interactions: Implications for Disease pp 17–35 Edited by Proffitt M. New York: Elsevier/North-Holland;
    [Google Scholar]
  22. Morahan P. S., Morse S. S., Mcgeorge M. B. 1980; Macrophage extrinsic antiviral activity during herpes simplex virus infection. Journal of General Virology 46:291–300
    [Google Scholar]
  23. Morse S. S., Morahan P. S. 1981; Activated macrophages mediate interferon-independent inhibition of herpes simplex virus. Cellular Immunology 58:72–84
    [Google Scholar]
  24. Nugent K. M., Pesanti E. L. 1979; Effect of influenza infection on the phagocytic and bactericidal activities of pulmonary macrophages. Infection and Immunity 26:651–657
    [Google Scholar]
  25. Oud Alblas A. B., Van Furth R. 1979; Origin, kinetics and characteristics of pulmonary macrophages in the normal steady state. Journal of Experimental Medicine 149:1504–1518
    [Google Scholar]
  26. Pace J. L., Russell S. W., Torres B. A., Johnson H. M., Gray P. W. 1983; Recombinant mouse interferon induces the priming step in macrophages activation for tumor cell killing. Journal of Immunology 130:2011–2013
    [Google Scholar]
  27. Probert M., Stott E. J., Thomas L. H. 1977; Interactions between calf alveolar macrophages and parainfluenza-3 virus. Infection and Immunity 15:576–585
    [Google Scholar]
  28. Rodgers B. C., Mims C. A. 1982; Role of macrophage activation and interferon in the resistance of alveolar macrophages from infected mice to influenza virus. Infection and Immunity 36:1154–1159
    [Google Scholar]
  29. Rouse B. T., Babiuk L. A. 1974; Host defense mechanisms against infectious bovine rhinotracheitis virus: in vitro stimulation of sensitized lymphocytes by virus antigen. Infection and Immunity 10:681–684
    [Google Scholar]
  30. Rouse B. T., Babiuk L. A. 1975; Defense mechanisms against infectious bovine rhinotracheitis virus: inhibition of virus infection by murine macrophages. Infection and Immunity 11:505–511
    [Google Scholar]
  31. Rouse B. T., Wardley R. C., Babiuk L. A. 1976; Antibody-dependent cell-mediated cytotoxicity in cows: comparison of effector cell activity against heterologous erythrocyte and herpesvirus-infected bovine target cells. Infection and Immunity 13:1433–1441
    [Google Scholar]
  32. Sen G. C., Herz R. E. 1983; Differential antiviral effects of interferon in three immune cell lines. Journal of Virology 45:1017–1027
    [Google Scholar]
  33. Stanwick T. L., Campbell D. E., Nahmias A. J. 1980; Spontaneous cytotoxicity mediated by human monocyte-macrophages against human fibroblasts infected with herpes simplex virus -augmentation by interferon. Cellular Immunology 53:413–416
    [Google Scholar]
  34. Stanwick T. L., Campbell D. E., Nahmias A. J. 1982; Cytotoxic properties of human monocyte-macrophages for human fibroblasts infected with herpes simplex virus: interferon production and augmentation. Cellular Immunology 70:132–147
    [Google Scholar]
  35. van Furth R. (editor) 1980; Mononuclear Phagocytes. Functional Aspects The Hague: Martinus Nijhoff;
    [Google Scholar]
  36. Vogel S. N., Finbloom D. S., English K. E., Rosenstreich D. L., Langreth S. G. 1983; Interferon-induced enhancement of macrophage Fc receptor expression: α-interferon treatment of C3H/HeJ macrophages results in increased numbers and density of Fc receptors. Journal of Immunology 130:1210–1214
    [Google Scholar]
  37. Warshauer D., Goldstein E., Abers T., Lippert W., Kim M. 1977; Effect of influenza viral infection on the ingestion and killing of bacteria by alveolar macrophages. American Review of Respiratory Diseases 115:269277
    [Google Scholar]
  38. Yoshie O., Mellman I. S., Broeze R. J., Garcia-Blanco M., Lengyel P. 1982; Interferon action: effects of mouse α and β interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309 Cr 1. Cellular Immunology 73:128–140
    [Google Scholar]
  39. Zwilling B. S., Campolita L. B., Reiches N. A. 1982; Alveolar macrophage subpopulations identified by differential centrifugation on a discontinuous albumin density gradient. American Review of Respiratory Diseases 125:448–452
    [Google Scholar]
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