1887

Abstract

SUMMARY

Homozygous athymic nude rats (rnu/rnu) infected intracerebrally with Borna disease virus produced relatively high titres of infectious virus in the central nervous system. However, no clinical signs of disease or pathological alterations could be found during a 100 day observation period. In contrast, heterozygous euthymic albino littermates (rnu/+), which were used as controls, reacted in a similar manner to immunocompetent Lewis rats. They developed behavioural alterations which coincided with encephalitis and retinitis. The results obtained confirm our previous concept that the genesis of Borna disease, at least in rats, is attributed to a cellular immune response.

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/content/journal/jgv/10.1099/0022-1317-66-3-503
1985-03-01
2024-04-28
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References

  1. Brooks C. G., Webb P. J., Robins G., Baldwin R. W., Festing M. F. W. 1980; Studies on the immunobiology of rnu/rnu nude rats with congenital aplasia of the thymus. European Journal of Immunology 10:58–65
    [Google Scholar]
  2. Burns J. 1975; Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material. Histochemistry 43:291–295
    [Google Scholar]
  3. Festing M. F. W., May D., Connors T. A., Lovell D., Sparrow S. 1978; An athymic nude mutation in the rat. Nature, London 274:356–366
    [Google Scholar]
  4. Herzog S., Rott R. 1980; Replication of Borna disease virus in cell cultures. Medical Microbiology and Immunology 168:153–158
    [Google Scholar]
  5. Hirano N., Kao M., Ludwig H. 1983; Persistent, tolerant or subacute infection in Borna disease virus-infected rats. Journal of General Virology 64:1521–1530
    [Google Scholar]
  6. Narayan O., Herzog S., Frese K., Scheefers H., Rott R. 1983a; Behavioral disease in rats caused by immunopathological responses to persistent Borna virus in the brain. Science 220:1401–1403
    [Google Scholar]
  7. Narayan O., Herzog S., Frese K., Scheefers H., Rott R. 1983b; Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. Journal of Infectious Diseases 148:305–315
    [Google Scholar]
  8. Schwinzer R., Wonigeit K., Hedrich H. J. 1984; Phenotypical characterization of T like lymphocytes in the congenitally athymic nude rat (rnu/rnu). Transplantation Proceedings (in press)
    [Google Scholar]
  9. Wonigeit K., Hedrich H. J. 1982; The athymic nude rat. An animal model for the extrathymic differentiation of T lymphocytes. Experimental Biology and Medicine 7:85
    [Google Scholar]
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