f The Products of Gene US11 of Herpes Simplex Virus Type 1 Are DNA-binding and Localize to the Nucleoli of Infected Cells
- Authors: Christine A. MacLean, Frazer J. Rixon, Howard S. Marsden
- J. Gen. Virol., July 1987 68: 1921-1937, doi: 10.1099/0022-1317-68-7-1921
- Subject: Animal
- Published Online:
We have used antisera raised against synthetic oligopeptides to characterize the protein products from herpes simplex virus type 1 gene US11. These antisera recognized predominantly polypeptides of apparent molecular weight 21000 and 22000, but also polypeptides of apparent molecular weight 17500, 15000, 14000 and 11000. Tryptic peptide fingerprint analysis confirmed that these polypeptides were all closely related. The 21000 and 22000 molecular weight polypeptides were shown to be DNA-binding proteins, and immune electron microscopy demonstrated their strong localization within nucleoli of infected cells.
© Society for General Microbiology 1987 | Published by the Microbiology Society
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