1887

Journal of General Virology header logo

Volume 70, Issue 12

Human Cytomegalovirus: Recent Aspects from Molecular Biology Free

Preview this article:
Preview Magnify

There is no abstract available.

  • Published Online:
Keyword(s): HCMV , herpesviruses and molecular biology
© Society for General Microbiology 1989
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-70-12-3117
1989-12-01
2024-04-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/70/12/JV0700123117.html?itemId=/content/journal/jgv/10.1099/0022-1317-70-12-3117&mimeType=html&fmt=ahah

References

  1. Adler S. P. 1983; Transfusion-associated cytomegalovirus infections. Review of Infectious Diseases 5:977–993
     [Google Scholar]
  2. Adler S. P. 1985; The molecular epidemiology of cytomegalovirus transmission among children attending a day care center. Journal of Infectious Diseases 152:760–768
     [Google Scholar]
  3. Akrigg A., Wilkinson G. W. G., Oram J. D. 1985; The structure of the major immediate early gene of human cytomegalovirus AD169. Virus Research 2:107–121
     [Google Scholar]
  4. Albrecht T., Rapp F. 1973; Malignant transformation of hamster embryo fibroblasts following exposure to UV-irradiated human cytomegalovirus. Virology 55:53–61
     [Google Scholar]
  5. Ambinder R. F., Newman C., Hayward G. S., Biggar R., Melbye M., Kestens L., Van MARCK E., Piot P., Gigase P., Wright P. B., Quinn T. C. 1987; Lack of association of cytomegalovirus with endemic African Kaposi’s sarcoma. Journal of Infectious Diseases 156:193–197
     [Google Scholar]
  6. Anders D. G., Gibson W. 1988; Location, transcript analysis, and partial nucleotide sequence of the cytomegalovirus gene encoding an early DNA-binding protein with similarities to ICP8 of Herpes simplex virus type 1. Journal of Virology 62:1364–1372
     [Google Scholar]
  7. Anders D. G., Kidd J. R., Gibson W. 1987; Immunological characterization of an early cytomegalovirus single-strand DNA binding with similarities to the HSV major DNA-binding protein. Virology 161:579–588
     [Google Scholar]
  8. Baer R., Bankier A. T., Biggin M. D., Deininger P. L., Farrell P. J., Gibson T. J., Hatfull G., Hudson G. S., Satchwell S. C., Seguin C., Tuffnell P. S., Barrell B. G. 1984; DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature, London 310:207–211
     [Google Scholar]
  9. Beck S., Barrell B. G. 1988; Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature, London 331:269–272
     [Google Scholar]
  10. Benko D. M., Gibson W. 1986; Primate cytomegalovirus glycoproteins, lectin-binding properties and sensitivities to glycosidases. Journal of Virology 59:703–713
     [Google Scholar]
  11. Blanton R. A., Tevethia M. J. 1981; Immunoprecipitation of virus-specific immediate-early and early polypeptides from cells lytically infected with human cytomegalovirus strain AD169. Virology 112:262–273
     [Google Scholar]
  12. Boldogh I., Beth E., Huang E-S., Kyalwazi K., Giraldo G. 1981; Kaposi’s sarcoma. IV. Detection of CMV DNA, CMV RNA and CMNA in tumor biopsies. International Journal of Cancer 28:469–474
     [Google Scholar]
  13. Boom R., Geelen J. L., Sol C. J., Raap A. K., Minnaar R. P., Klaver B. P., Van Der Noordaa J. 1986; Establishment of a rat cell line inducible for the expression of human cytomegalovirus immediate-early gene products by protein synthesis inhibition. Journal of Virology 58:851–859
     [Google Scholar]
  14. Borisch B., Jahn G., Scholl B.-C., Filger-Brillinger J., Heymer B., Fleckenstein B., Müller-Hermelink H.-K. 1988; Detection of human cytomegalovirus DNA and viral antigens in tissues of different manifestations of CMV infection. Virchows Archiv für pathologische Anatomie 55:93–99
     [Google Scholar]
  15. Boshart M., Weber F., Jahn G., Dorsch-Häsler K., Fleckenstein B., Schaffner W. 1985; A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell 41:521–530
     [Google Scholar]
  16. Brandt J. A., Kettering J. D., Lewis J. E. 1984; Immunity to human cytomegalovirus measured and compared by complement fixation, indirect fluorescent-antibody, indirect hemagglutination, and enzyme-linked immunosorbent assays. Journal of Clinical Microbiology 19:147–152
     [Google Scholar]
  17. Brichácek B., Hirsch I., Závadová H., Procházka M., Faltyn J., Vonka V. 1980; Absence of cytomegalovirus DNA from adenocarcinoma of the colon. Intervirology 14:223–227
     [Google Scholar]
  18. Britt W. J. 1984; Neutralizing antibodies detect a disulfide-linked glycoprotein complex within the envelope of human cytomegalovirus. Virology 135:369–378
     [Google Scholar]
  19. Britt W. J., Auger D. 1985; Identification of a 65000 dalton virion envelope protein of human cytomegalovirus. Virus Research 4:31–36
     [Google Scholar]
  20. Britt W. J., Auger D. 1986a; Synthesis and processing of the envelope gp55-116 complex of human cytomegalovirus. Journal of Virology 58:185–191
     [Google Scholar]
  21. Britt W. J., Auger D. 1986b; Human cytomegalovirus virion-associated protein with kinase activity. Journal of Virology 59:185–188
     [Google Scholar]
  22. Britt W. J., Vugler L., Stephens E. B. 1988; Induction of complement-dependent and -independent neutralizing antibodies by recombinant-derived human cytomegalovirus gp55-116 (gB). Journal of Virology 62:3309–3318
     [Google Scholar]
  23. Cameron J. M., Preston C. M. 1981; Comparison of the immediate early polypeptides of human cytomegalovirus isolates. Journal of General Virology 54:421–424
     [Google Scholar]
  24. Chandler S. H., McDougall J. K. 1986; Comparison of restriction site polymorphisms among clinical isolates and laboratory strains of human cytomegalovirus. Journal of General Virology 67:2179–2192
     [Google Scholar]
  25. Chandler S. H., Handsfield H. H., McDougall J. K. 1987; Isolation of multiple strains of cytomegalovirus from women attending a clinic for sexually transmitted diseases. Journal of Infectious Diseases 155:655–660
     [Google Scholar]
  26. Chang C-P., Malone C. L., Stinski M. F. 1989; A human cytomegalovirus early gene has three inducible promoters that are regulated differentially at various times after infection. Journal of Virology 63:281–290
     [Google Scholar]
  27. Chou S., Merigan T. C. 1983; Rapid detection and quantitation of human cytomegalovirus in urine through DNA hybridization. New England Journal of Medicine 308:921–925
     [Google Scholar]
  28. Chou S., Scott K. M. 1988; Rapid quantitation of cytomegalovirus and assay of neutralizing antibody by using monoclonal antibody to the major immediate-early viral protein. Journal of Clinical Microbiology 26:504–507
     [Google Scholar]
  29. Chou S., Roark L., Merigan T. C. 1984; DNA of 21 clinical cytomegalovirus strains detected by hybridization to cloned DNA fragments of laboratory strain AD169 . Journal of Medical Virology 14:263–268
     [Google Scholar]
  30. Clark B. R., Zaia J. A., Balce-Directo L., Ting Y-P. 1984; Isolation and partial chemical characterization of a 64000 dalton glycoprotein of human cytomegalovirus. Journal of Virology 49:279–282
     [Google Scholar]
  31. Clements J. B., Watson R. J., Wilkie N. M. 1977; Temporal regulation of herpes simplex virus type 1 transcription; location of transcripts on the viral genome. Cell 12:275–285
     [Google Scholar]
  32. Cranage M. P., Kouzarides T., Bankier A. T., Satchwell S. C., Weston K., Tomlinson P., Barrell B. G., Hart H., Bell S. E., Minson A. C., Smith G. L. 1986; Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus. EMBO Journal 5:3057–3063
     [Google Scholar]
  33. Cranage M. P., Smith G. L., Bell S. E., Hart H., Brown C., Bankier A. T., Tomlinson P., Barrell B. G., Minson T. C. 1988; Identification and expression of a human cytomegalovirus glycoprotein with homology to the Epstein–Barr virus BXLF2 product, varicella-zoster virus gpIII, and herpes simplex virus type 1 glycoprotein H. Journal of Virology 62:1416–1422
     [Google Scholar]
  34. Davis M. G., Huang E-S. 1985; Nucleotide sequence of a human cytomegalovirus DNA fragment encoding a 67- kilodalton phosphorylated viral protein. Journal of Virology 56:7–11
     [Google Scholar]
  35. Davis M. G., Mar E., Wu Y., Huang E-S. 1984; Mapping and expression of a human cytomegalovirus major viral protein. Journal of Virology 52:129–135
     [Google Scholar]
  36. Davis M. G., Kenney S. C., Kamine J., Pagano J. S., Huang E-S. 1987; Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus. Proceedings of the National Academy of SciencesU.S.A 84:8642–8646
     [Google Scholar]
  37. Davison A. J., Scott J. E. 1986; The complete DNA sequence of varicella-zoster virus. Journal of General Virology 67:1759–1816
     [Google Scholar]
  38. Davison A. J., Taylor P. 1987; Genetic relations between varicella-zoster virus and Epstein–Barr virus. Journal of General Virology 68:1067–1079
     [Google Scholar]
  39. Deluca N. A., Courtney M. A., Schaffer P. A. 1984; Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression. Journal of Virology 52:767–776
     [Google Scholar]
  40. Demarchi J. M. 1981; Human cytomegalovirus D NA: restriction enzyme cleavage maps and map locations for immediate-early, early, and late RNAs. Virology 114:23–38
     [Google Scholar]
  41. Demarchi J. M. 1984; The physical and transcriptional organization of the human cytomegalovirus genome. In CMV: Pathogenesis and Prevention of Human Infection 2035–47 Plotkin S. A. New York: Alan R. Liss;
     [Google Scholar]
  42. Demarchi J. M., Blankenship M. L., Brown G. D., Kaplan A. S. 1978; Size and complexity of human cytomegalovirus DNA. Virology 89:643
     [Google Scholar]
  43. Dhpg Treatment Study Group 1986; Treatment of serious cytomegalovirus infections with 9-(1, 3-dihydroxy-2-propoxymethyl)guanine in patients with AIDS and other immunodeficiencies. New England Journal of Medicine 314:801–805
     [Google Scholar]
  44. Dorsch-Häsler K., Keil G. M., Weber F., Jasin M., Schaffner W., Koszinowski U. H. 1985; A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus. Proceedings of the National Academy of SciencesU.S.A 82:8325–8329
     [Google Scholar]
  45. Drew W. L., Conant M. A., Miner R. C., Huang E-S., Ziegler J. R., Groundwater J. R., Gullett J. H., Volberding P., Abrams D. I., Mintz L. 1982; Cytomegalovirus and Kaposi’s sarcoma in young homosexual men. Lancet ii:125–127
     [Google Scholar]
  46. Drew W. L., Sweet E. S., Miner R. C., Mocarski E. S. 1984; Multiple infections by cytomegalovirus in patients with acquired immunodeficiency syndrome: documentation by Southern blot hybridization. Journal of Infectious Diseases 6:952–953
     [Google Scholar]
  47. Dworsky M. E., Yow M., Stagno S., Pass R. F., Alford C. A. 1983; Cytomegalovirus infection of breast milk and transmission in infancy. Pediatrics 72:295–299
     [Google Scholar]
  48. Dylewski J., Chou S., Merigan T. C. 1983; Absence of detectable IgM antibody during cytomegalovirus disease in patients with AIDS. New England Journal of Medicine 309:493
     [Google Scholar]
  49. Easton A. J., Clements J. B. 1980; Temporal regulation of herpes simplex virus type 2 transcription and characterization of virus immediate early mRNAs. Nucleic Acids Research 8:2627–2645
     [Google Scholar]
  50. Ebeling A., Keil G. M., Knust E., Koszinowski U. H. 1983a; Molecular cloning and physical mapping of murine cytomegalovirus DNA. Journal of Virology 47:421–433
     [Google Scholar]
  51. Ebeling A., Keil G., Nowak B., Fleckenstein B., Berthelot N., Sheldrick P. 1983b; Genome structure and virion polypeptides of the primate herpesviruses Herpvevirus aotus types 1 & 3 : comparison with human cytomegalovirus. Journal of Virology 45:715–726
     [Google Scholar]
  52. Edson C. M., Thorley-Lawson D. A. 1981; Epstein-Barr virus membrane antigens: characterization, distribution and strain differences. Journal of Virology 39:172–184
     [Google Scholar]
  53. Eizuru Y., Inagawa S., Minamishima Y. 1984; Application of ‘Hirt supernatant’ DNA to the molecular epidemiology of cytomegalovirus infections. Journal of Clinical Microbiology 20:1012–1014
     [Google Scholar]
  54. El-Beik T., Razzaque A., Jariwalla R., Cihlar R. L., Rosenthal L. J. 1986; Multiple transforming regions of human cytomegalovirus DNA. Journal of Virology 60:645–652
     [Google Scholar]
  55. Elion G. B., Furman P. A., Fyfe J. A., De Miranda P., Beauchamp L., Schaeffer H. F. 1977; Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proceedings of the National Academy of SciencesU.S.A 74:5716–5720
     [Google Scholar]
  56. Emanuel D., Peppard J., Chehimi J., Hammerling U., O’reilly R. 1987; The diagnostic, prophylactic, and therapeutic uses of monoclonal antibodies to human cytomegalovirus. Transplantation Proceedings 6:132–137
     [Google Scholar]
  57. Emini E., Luka J., Armstrong M., Keller P., Ellis R., Pearson G. 1987; Identification of an Epstein-Barr virus glycoprotein which is antigenically homologous to the varicella zoster glycoprotein II and the herpes simplex virus glycoprotein B. Virology 157:552–555
     [Google Scholar]
  58. Espy M. J., Smith T. F. 1987; Simultaneous seeding and infecting of shell vials for rapid detection of cytomegalovirus infection. Journal of Clinical Microbiology 25:940–941
     [Google Scholar]
  59. Estes J., Huang H-S. 1977; Stimulation of cellular thymidine kinase by human cytomegalovirus. Journal of Virology 24:13–21
     [Google Scholar]
  60. Everett R. D., Dunlop M. 1984; Trans-activation of plasmid-borne promoters by adenovirus and several herpes group viruses. Nucleic Acids Research 12:5969–5978
     [Google Scholar]
  61. Farrar G. H., Greenaway P. J. 1986; Characterization of glycoprotein complexes present in human cytomegalovirus envelopes. Journal of General Virology 67:1469–1473
     [Google Scholar]
  62. Fickenscher H., Stamminger T., Ruger R., Fleckenstein B. 1989; The role of a repetitive palindromic sequence element in the human cytomegalovirus major immediate early enhancer. Journal of General Virology 70:107–123
     [Google Scholar]
  63. Fleckenstein B., Müller I., Collins J. 1982; Cloning of the complete human cytomegalovirus genome in cosmids. Gene 18:39–46
     [Google Scholar]
  64. Foecking M. K., Hofstetter H. 1986; Powerful and versatile enhancer-promoter unit for mammalian expression vectors. Gene 45:101–105
     [Google Scholar]
  65. Forman S. J., Zaia J. A., Clark B. R., Wright C. L., Mills B. J., Pottathil R., Rackin B. C., Gallagher M. T., Welte K., Blume K. G. 1985; A 64000 dalton matrix protein of human cytomegalovirus induces in vitro immune responses similar to those of whole viral antigen. Journal of Immunology 134:3391–3395
     [Google Scholar]
  66. Galloway D. A., McDougall J. K. 1983; The oncogenic potential of herpes simplex viruses, evidence for a ‘hit-and-run’ mechanism. Nature, London 302:21–24
     [Google Scholar]
  67. Geballe A. P., Leach F. S., Mocarski E. S. 1986; Regulation of cytomegalovirus late gene expression: alpha genes are controlled by post-transcriptional events. Journal of Virology 57:864–874
     [Google Scholar]
  68. Geelen J. L. M. C., Walig C., Wertheim P., Van der Noordaa J. 1978; Human cytomegalovirus DNA. I. Molecular weight and infectivity. Journal of Virology 26:813–816
     [Google Scholar]
  69. Geelen J. L. M. C., Boom R., Klaver G. P. M., Minnaar R. P., Feltkamp M. C. W., Van Milligen F. J., Sol C. J. A., Van der noordaa J. 1987; Transcriptional activation of the major immediate early transcription unit of human cytomegalovirus by heat-shock, arsenite and protein synthesis inhibitors. Journal of General Virology 68:2925–2931
     [Google Scholar]
  70. Gelmann E. P., Clanton D. J., Jariwalla R. J., Rosenthal L. J. 1983; Characterization and location of myc homologous sequences in human cytomegalovirus DNA. Proceedings of the National Academy of SciencesU.S.A 80:5107–5111
     [Google Scholar]
  71. Ghazal P., Lubon H., Fleckenstein B., Hennighausen L. 1987; Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer. Proceedings of the National Academy of SciencesU.S.A 84:3658–3662
     [Google Scholar]
  72. Ghazal P., Lubon H., Hennighausen L. 1988a; Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro . Molecular and Cellular Biology 8:1809–1811
     [Google Scholar]
  73. Ghazal P., Lubon H., Hennighausen L. 1988b; Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene. Journal of Virology 62:1076–1079
     [Google Scholar]
  74. Gibson W. 1981a; Structural and non-structural proteins of strain Colborn cytomegalovirus. Virology 111:516–537
     [Google Scholar]
  75. Gibson W. 1981b; Immediate-early proteins of human cytomegalovirus strains AD169, Davis and Towne differ in electrophoretic mobility. Virology 112:350–354
     [Google Scholar]
  76. Gibson W. 1983; Protein counterparts of human and simian cytomegaloviruses. Virology 128:391–406
     [Google Scholar]
  77. Gibson W., Irmiere A. 1984; Selection of particles and proteins for use as human cytomegalovirus subunit vaccines. In CMV: Pathogenesis and Prevention of Human Infection 20305–324 Plotkin S. A. New York: Alan R. Liss;
     [Google Scholar]
  78. Giraldo G., Beth E., Coeur P., Vogel C. L., Dhru D. S. 1972a; Kaposi’s sarcoma, a new model in the search for viruses associated with human malignancies. Journal of the National Cancer Institute 49:1495–1507
     [Google Scholar]
  79. Giraldo G., beth E., Haguenau F. 1972b; Herpes-type virus particles in tissue culture of Kaposi’s sarcoma from different geographic regions. Journal of the National Cancer Institute 49:1509–1526
     [Google Scholar]
  80. Giraldo G., Beth E., Kourilsky F. M., Henle W., Miké V., Huraux V. M., Andersen H. K., Gharbi M. R., Kyalwazi S. K., Puissant A. 1975; Antibody patterns to herpesviruses in Kaposi’s sarcoma, serological association of European Kaposi’s sarcoma with cytomegalovirus. International Journal of Cancer 15:839–848
     [Google Scholar]
  81. Giraldo G., Beth E., Henle W., Henle G., Miké V., Safai B., Huraux J. M., McHardy J., De-Thé G. 1978; Antibody patterns to herpesviruses in Kaposi’s sarcoma. II. Serological association of American Kaposi’s sarcoma with cytomegalovirus. International Journal of Cancer 22:126–131
     [Google Scholar]
  82. Giraldo G., Beth E., Huang E-S. 1980; Kaposi’s sarcoma and its relationship to cytomegalovirus (CMV). III. CMV DNA and CMV early antigens in Kaposi’s sarcoma. International Journal of Cancer 26:23–29
     [Google Scholar]
  83. Goldstein L. C., McDougall J., Hackman R., Meyers J. D., Thomas E. D., Nowinski R. C. 1982; Monoclonal antibodies to cytomegalovirus: rapid identification of clinical isolates and preliminary use in diagnosis of cytomegalovirus pneumonia. Infection and Immunity 38:273–281
     [Google Scholar]
  84. Gönczöl E., Hudecz F., Ianacone J., Dietzschold B., Starr S., Plotkin S. A. 1986; Immune responses to isolated human cytomegalovirus envelope proteins. Journal of Virology 58:661–664
     [Google Scholar]
  85. Greenaway P. J., Wilkinson G. W. G. 1987; Nucleotide sequence of the most abundantly transcribed early gene of human cytomegalovirus strain AD 169. Virus Research 7:17–31
     [Google Scholar]
  86. Greenaway P. J., Oram J. D., Downing R. G., Patel K. 1982; Human cytomegalovirus DNA; BamHI, EcoRI and PstI restriction endonuclease cleavage maps. Gene 18:355–360
     [Google Scholar]
  87. Gretch D. R., Kari B., Rasmussen L., Gehrz R. C., Stinski M. F. 1988a; Identification and characterization of three distinct families of glycoprotein complexes in the envelope of human cytomegalovirus. Journal of Virology 62:875–881
     [Google Scholar]
  88. Gretch D. R., Kari B., Gehrz R. C., Stinski M. F. 1988b; A multigene family encodes the human cytomegalovirus glycoprotein complex gcII (gp47-52 complex). Journal of Virology 62:1956–1962
     [Google Scholar]
  89. Grillner L., Blomberg I. 1984; Restriction enzyme analysis of human cytomegalovirus using DNA extracted from infected cells. Journal of Medical Virology 14:313–322
     [Google Scholar]
  90. Grundy J. E., McKeating J. A., Griffiths P. D. 1987a; Cytomegalovirus strain AD169 binds β 2 microglobulin in vitro after release from cells. Journal of General Virology 68:777–784
     [Google Scholar]
  91. Grundy J. E., McKeating J. A., Ward P. J., Sanderson A. R., Griffiths P. D. 1987b; β2 Microglobulin enhances the infectivity of cytomegalovirus and when bound to the virus enables class IHLA molecules to be used as a virus receptor. Journal of General Virology 68:793–803
     [Google Scholar]
  92. Hashiro G. M., Horikami S., Loh P. C. 1979; Cytomegalovirus isolations from cell cultures of human adenocarcinomas of the colon. Intervirology 12:84–88
     [Google Scholar]
  93. Heilbronn R., Jahn G., Burkle A., Freese U.-K., Fleckenstein B., Zur Hausen H. 1987; Genomic localization, sequence analysis, transcription of the putative human cytomegalovirus DNA polymerase gene. Journal of Virology 61:119–124
     [Google Scholar]
  94. Hennighausen L., Fleckenstein B. 1986; Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene. EMBO Journal 5:1367–1371
     [Google Scholar]
  95. Hermiston T. W., Malone C. L., Witte P. R., Stinski M. F. 1987; Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter. Journal of Virology 61:3214–3221
     [Google Scholar]
  96. Honess R. W., Roizman B. 1974; Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. Journal of Virology 14:8–19
     [Google Scholar]
  97. Honess R. W., Roizman B. 1975; Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. Proceedings of the National Academy of SciencesU.S.A 72:1276–1280
     [Google Scholar]
  98. Huang E-S. 1975; Human cytomegalovirus. III. Virus-induced DNA polymerase. Journal of Virology 16:298–310
     [Google Scholar]
  99. Huang E-S., Pagano J. S. 1974; Human cytomegalovirus. II. Lack of relatedness to DNA of HSV-1 & -2, EBV, and non-human strains of cytomegalovirus. Journal of Virology 13:642–645
     [Google Scholar]
  100. Huang E-S., Roche R. K. 1978; Cytomegalovirus DNA and adenocarcinoma of the colon, evidence for latent viral infection. Lancet i:957–960
     [Google Scholar]
  101. Huang E-S., Chen S. T., Pagano J. S. 1973; Human cytomegalovirus. I. Purification and characterization of viral DNA. Journal of Virology 12:1473–1481
     [Google Scholar]
  102. Huang E-S., Kilpatrick B. A., Huang Y. T., Pagano J. S. 1976; Detection of human cytomegalovirus and analysis of strain variation. Yale Journal of Biology and Medicine 49:29
     [Google Scholar]
  103. Huang E-S., Alford C. A., Reynolds D. W., Stagno S., Pass R. F. 1980a; Molecular epidemiology of cytomegalovirus infections in women and their infants. New England Journal of Medicine 303:958–962
     [Google Scholar]
  104. Huang E-S., Huong S-M., Tegtmeier G. E., Alford C. A. 1980b; Cytomegalovirus: genetic variation of viral genomes. Annals of the New York Academy of Sciences 354:332–354
     [Google Scholar]
  105. Hutchinson N. I., Tocci M. J. 1986; Characterization of a major early gene from the human cytomegalovirus long inverted repeat; predicted amino acid sequence of a 30 kDa protein encoded by the 1·2 kb mRNA. Virology 155:172–182
     [Google Scholar]
  106. Hutchinson N. I., Sondermeyer R. T., Tocci M. J. 1986; Organization and expression of the major genes from the long inverted repeat of the human cytomegalovirus genome. Virology 155:160–171
     [Google Scholar]
  107. Irmiere A., Gibson W. 1983; Isolation and characterization of a non-infectious virion-like particle released from cells infected with human strains of cytomegalovirus. Virology 130:118–130
     [Google Scholar]
  108. Irmiere A., Gibson W. 1985; Isolation of human cytomegalovirus intranuclear capsids, characterization of their protein constituents, and demonstration that the B-capsid assembly protein is also abundant in non-infectious enveloped particles. Journal of Virology 56:277–283
     [Google Scholar]
  109. Isom H. C. 1979; Stimulation of ornithine decarboxylase by human cytomegalovirus. Journal of General Virology 42:265–278
     [Google Scholar]
  110. Jahn G., Knust E., Schmolla H., Sarre T., Nelson J. A., McDougall J. K., Fleckenstein B. 1984; Predominant immediate early transcripts of human cytomegalovirus AD169. Journal of Virology 49:363–370
     [Google Scholar]
  111. Jahn G., Scholl B.-C., Traupe B., Fleckenstein B. 1987a; The two major structural phosphoproteins (pp65 and pp 150) of human cytomegalovirus and their antigenic properties. Journal of General Virology 68:1327–1337
     [Google Scholar]
  112. Jahn G., Kouzarides T., Mach M., Scholl B.-C., Plachter B., Traupe B., Preddie E., Satchwell S. C., Fleckenstein B., Barrell B. G. 1987b; Map position and nucleotide sequence of the gene for the large structural phosphoprotein of human cytomegalovirus. Journal of Virology 61:1358–1367
     [Google Scholar]
  113. Jeang K-T., Rawlins D. R., Rosenfeld P. J., Shero J. H., Kelly T. J., Hayward G. S. 1987; Multiple tandemly repeated binding sites for cellular nuclear factor 1 that surround the major immediate-early promoters of simian and human cytomegalovirus. Journal of Virology 61:1559–1570
     [Google Scholar]
  114. Jeang J-T., Hayward G. S. 1983; A cytomegalovirus DNA sequence containing tracts of tandemly repeated CA dinucleotides hybridizes to highly repetitive dispersed elements in mammalian cell genomes. Molecular and Cellular Biology 3:1389–1402
     [Google Scholar]
  115. Kari B., Lussenhop N., Goertz R., Wabuke-Bunoti M., Radeke R., Gehrz R. 1986; Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes. Journal of Virology 60:345–352
     [Google Scholar]
  116. Keller P. M., Davison A. J., Lowe R., Bennett C., Ellis R. 1986; Identification and structure of the gene encoding gpII, a major glycoprotein of varicella zoster virus. Virology 152:181–191
     [Google Scholar]
  117. Kemble G. W., McCormick A. L., Pereira L., Mocarski E. S. 1987; A cytomegalovirus protein with properties of herpes simplex virus ICP8 : partial purification of the polypeptide and map position of the gene. Journal of Virology 61:3143–3151
     [Google Scholar]
  118. Kouzarides T., Bankier A. T., Satchwell S. S., Weston K., Tomlinson P., Barrell B. G. 1987a; Large scale rearrangement of homologous regions in the genome of HCMV and EBV. Virology 157:397–413
     [Google Scholar]
  119. Kouzarides T., Bankier A. T., Satchwell S. S., Weston K., Tomlinson P., Barrell B. G. 1987b; Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene. Journal of Virology 61:125–133
     [Google Scholar]
  120. LaFemina R. L., Hayward G. S. 1980; Structural organization of the DNA molecules from human cytomegalovirus. In Animal Virus Genetics39–55 Fields B. N., Jaenisch R. New York: Academic Press;
     [Google Scholar]
  121. LaFemina R. L., Hayward G. S. 1983; Replicative forms of human cytomegalovirus DNA with joined termini are found in permissively infected human cells but not in non-permissive Balb/c-3T3 mouse cells. Journal of General Virology 64:373–389
     [Google Scholar]
  122. LaFemina R. L., Hayward G. S. 1988; Differences in cell type-specific blocks to immediate early gene expression and DNA replication of human, simian and murine cytomegalovirus. Journal of General Virology 69:355–374
     [Google Scholar]
  123. LaKeman A. D., Osborn J. E. 1979; Size of infectious DNA from human and murine cytomegalovirus. Journal of Virology 30:414–416
     [Google Scholar]
  124. Landini M. P., Michelson S. 1988; Human cytomegalovirus proteins. Progress in Medical Virology 35:152–185
     [Google Scholar]
  125. Landini M. P., Re M. C., Mirolo G., Baldassari B., Laplaca M. 1985; Human immune response to cytomegalovirus structural polypeptides studied by immunoblotting. Journal of Medical Virology 17:303–311
     [Google Scholar]
  126. Landini M. P., Severi B., Badiali L., Gönczöl E., Mirolo G. 1987a; Structural components of human cytomegalovirus: in situ localization of the major glycoprotein. Intervirology 27:154–160
     [Google Scholar]
  127. Landini M. P., Severi B., Furlini G., Badiali de Giorgi L. 1987b; Human cytomegalovirus structural components: intracellular and intraviral localization of p28 and p65-69 by immunoelectron microscopy. Virus Research 8:15–23
     [Google Scholar]
  128. Law K., Wilton-Smith P., Farrar G. H. 1985; A murine monoclonal antibody recognizing a single glycoprotein within a human cytomegalovirus virion envelope glycoprotein complex. Journal of Medical Virology 17:255–266
     [Google Scholar]
  129. Liu Y-N., Kari B., Gehrz R. 1988; Human immune response to major human cytomegalovirus glycoprotein complexes. Journal of Virology 62:1066–1070
     [Google Scholar]
  130. Löning T., Milde K., Foss H.-D. 1986; In situ hybridization for the detection of cytomegalovirus (CMV) infection. Virchows Archiv für pathologische Anatomie 409:777–790
     [Google Scholar]
  131. Lubon H., Ghazal P., Hennighausen L., Reynolds-Kohler C., Lockshin C., Nelson J. A. 1989; Cell-specific activity of the modulator region in the human cytomegalovirus major immediate early gene. Molecular and Cellular Biology 9:1342–1345
     [Google Scholar]
  132. McDonough S., Spector D. 1983; Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169. Virology 125:31–46
     [Google Scholar]
  133. McDonough S. H., Staprans S. I., Spector D. H. 1985; Analysis of the major transcripts encoded by the long repeat of human cytomegalovirus strain AD169. Journal of Virology 53:711–718
     [Google Scholar]
  134. McFarlane E. S., Koment R. W. 1986; Use of restriction endonuclease digestion to analyse strains of human cytomegalovirus isolated concurrently from an immunocompetent heterosexual man. Journal of Infectious Diseases 154:167–168
     [Google Scholar]
  135. McGeoch D. J., Dolan A., Donald S., Rixon F. J. 1985; Sequence determination and genetic content of the short unique region of the genome of herpes simplex virus type 1. Journal of Molecular Biology 181:1–13
     [Google Scholar]
  136. McGeoch D. J., Dalrymple M. A., Davison A. J., Dolan A., Frame M. C., McNab D., Perry L. J., Scott J. E., Taylor P. 1988; The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. Journal of General Virology 69:1531–1574
     [Google Scholar]
  137. Mach M., Utz U., Fleckenstein B. 1986; Mapping of the major glycoprotein gene of human cytomegalovirus. Journal of General Virology 67:1461–1467
     [Google Scholar]
  138. McKeating J. A., Griffiths P. D., Grundy E. J. 1987; Cytomegalovirus in urine specimens has host β2 microglobulin bound to the viral envelope: a mechanism of evading the host immune response?. Journal of General Virology 68:785–792
     [Google Scholar]
  139. Macnab J. C. M. 1987; Herpes simplex virus and human cytomegalovirus: their role in morphological transformation and genital cancers. Journal of General Virology 68:2525–2550
     [Google Scholar]
  140. Mar E-C., Patel P. C., Huang E-S. 1981; Human cytomegalovirus-associated DNA polymerase and protein kinase activities. Journal of General Virology 57:149–156
     [Google Scholar]
  141. Mar E-C., Chiou J-F., Cheng Y-C., Huang E-S. 1985a; Inhibition of cellular DNA polymerase α and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1, 3-dihydroxy-2-propoxymethyl)guanine. Journal of Virology 53:776–780
     [Google Scholar]
  142. Mar E-C., Chiou J-F., Cheng Y-C., Huang E-S. 1985b; Human cytomegalovirus-induced DNA polymerase and its interaction with the triphosphates of 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-methyluracil, -5-iodocytosine, and -5-methylcytosine. Journal of Virology 56:846–851
     [Google Scholar]
  143. Marshalek R., Amon-Bohm E., Stoerker J., Klages S., Fleckenstein B., Dingermann T. 1989; CMER, an RNA encoded by human cytomegalovirus is most likely transcribed by RNA polymerase III. Nucleic Acids Research 17:631–643
     [Google Scholar]
  144. Meijer H., Dormans P. H. J., Geelen J. L. M. C., Van boven C. P. A. 1984; Rat cytomegalovirus: studies on the viral genome and the proteins of virions and nucleocapsids. Journal of General Virology 65:681–695
     [Google Scholar]
  145. Melnick J. L., Lewis R., Wimberly I., Kaufman R. H., Adam E. 1978; Association of cytomegalovirus (CMV) infection with cervical cancer: isolation of CMV from cell cultures derived from cervical biopsy. Intervirology 10:115–119
     [Google Scholar]
  146. Melnick J. L., Adam E., Lewis R., Kaufman R. H. 1979; Cervical cancer cell lines containing herpesvirus markers. Intervirology 12:111–114
     [Google Scholar]
  147. Mercer J., Marks J., Spector D. H. 1983; Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith strain). Virology 131:247–254
     [Google Scholar]
  148. Meyer H., Bankier A. T., Landini M. P., Brown C. M., Barrell B. G., Ruger B., Mach M. 1988; Identification and procaryotic expression of the gene coding for the highly immunogenic 28 kD structural phosphoprotein (pp28) of human cytomegalovirus. Journal of Virology 62:2243–2250
     [Google Scholar]
  149. Michelson S., Tardy-Panit M., Barzu O. 1984; Properties of a human cytomegalovirus-induced protein kinase. Virology 134:259–268
     [Google Scholar]
  150. Michelson S., Tardy-Panit M., Barzu O. 1985; Catalytic properties of human cytomegalovirus-induced protein kinase. European Journal of Biochemistry 149:393–399
     [Google Scholar]
  151. Michelson-Fiske S., Horodniceanu F., Guillon J-C. 1977; Immediate early antigens in human cytomegalovirus infected cells. Nature, London 270:615–647
     [Google Scholar]
  152. Mocarski E. S., Pereira L., Michael N. 1985; Precise localization of genes on large animal virus genomes: use of lambda gtl 1 and monoclonal antibodies to map the gene for a cytomegalovirus protein family. Proceedings of the National Academy of SciencesU.S.A 82:1266–1270
     [Google Scholar]
  153. Mocarski E. S., Liu A. C., Spaete R. R. 1987; Structure and variability of the a sequence in the genome of human cytomegalovirus (Towne strain). Journal of General Virology 68:2223–2230
     [Google Scholar]
  154. Montminy M. R., Sevarino K. A., Wagner J. A., Mandel G., Goodman R. H. 1986; Identification of a cyclin- AMP-responsive element within the rat somatostatin gene. Proceedings of the National Academy of SciencesU.S.A 83:6682–6686
     [Google Scholar]
  155. Mueller N., Hinkula J., Wahren B. 1988; Elevated antibody titres against cytomegalovirus among patients with testicular cancer. International Journal of Cancer 41:399–403
     [Google Scholar]
  156. Murchie M. J., McGeoch D. J. 1982; DNA sequence analysis of an immediate-early gene region of herpes simplex virus type 1 genome (map coordinates 0·950 to 0·978). Journal of General Virology 62:1–15
     [Google Scholar]
  157. Myerson D., Hackman R. C., Meyers J. D. 1984a; Diagnosis of cytomegaloviral pneumonia by in situ hybridization. Journal of Infectious Diseases 150:272–277
     [Google Scholar]
  158. Myerson D., Hackman R. C., Nelson J. A., Ward D. C., McDougall J. K. 1984b; Widespread presence of histologically occult cytomegalovirus. Human Pathology 15:430–439
     [Google Scholar]
  159. Nelson J. A., Groudine M. 1986; Transcriptional regulation of the human cytomegalovirus major immediate-early gene is associated with induction of DNAase I-hypersensitive sites. Molecular and Cellular Biology 6:452–461
     [Google Scholar]
  160. Nelson J. A., Fleckenstein B., Galloway D. A., McDougall J. K. 1982; Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD169. Journal of Virology 43:83–91
     [Google Scholar]
  161. Nelson J. A., Fleckenstein B., Jahn G., Galloway D. A., McDougall J. K. 1984; Structure of the transforming region of human cytomegalovirus AD169. Journal of Virology 49:109–115
     [Google Scholar]
  162. Nelson J. A., Reynolds-Kohler C., Smith B. A. 1987; Negative and positive regulation by a short segment in the 5′ flanking region of the human cytomegalovirus major immediate-early gene. Molecular and Cellular Biology 7:4125–4129
     [Google Scholar]
  163. Nishiyama Y., Maeno K., Yoshida S. 1983; Characterization of human cytomegalovirus induced DNA polymerase and the associated 3′ to 5′ exonuclease. Virology 124:221–231
     [Google Scholar]
  164. Nowak B., Gmeiner A., Sarnow P., Levine A. J., Fleckenstein B. 1984a; Physical mapping of human cytomegalovirus genes, identification of DNA sequences coding for a virion phosphoprotein of 71 kD and a viral 65 kD polypeptide. Virology 134:91–102
     [Google Scholar]
  165. Nowak B., Sullivan C., Sarnow P., Thomas R., Bricaut F., Nicolas I. C., Fleckenstein B., Levine A. J. 1984b; Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins. Virology 132:325–338
     [Google Scholar]
  166. O’Hare P., Hayward G. S. 1985; Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters. Journal of Virology 53:751–760
     [Google Scholar]
  167. Onorato I. M., Morens D. M., Martone W. J., Stansfield S. K. 1985; Epidemiology of cytomegaloviral infections: recommendations for prevention and control. Review of Infectious Diseases 7:479–497
     [Google Scholar]
  168. Oram J. D., Downing R. G., Akrigg A., Dollery A. A., Duggleby C. J., Wilkinson G. W. G., Greenaway P. J. 1982; Use of recombinant plasmids to investigate the structure of the human cytomegalovirus genome. Journal of General Virology 59:111–129
     [Google Scholar]
  169. Pande H., Baak S. W., Riggs A. D., Clark B. R., Shively J. E., Zaia J. A. 1984; Cloning and physical mapping of a gene fragment coding for a 64-kilodalton major late antigen of human cytomegalovirus. Proceedings of the National Academy of SciencesU.S.A 81:4965–4969
     [Google Scholar]
  170. Pass R. F., Stagno S., Myers G. J., Alford C. A. 1980; Outcome of symptomatic congenital CMV infection: results of long-term longitudinal follow-up. Pediatrics 66:758–762
     [Google Scholar]
  171. Pass R. F., Griffiths P. D., August A. M. 1983; Antibody response to cytomegalovirus after renal transplantation: comparison of patients with primary and recurrent infections. Journal of Infectious Diseases 147:40–46
     [Google Scholar]
  172. Pass R. F., Little E. A., Stagno S., Britt W. J., Alford C. A. 1987; Young children as a probable source of maternal and congenital cytomegalovirus infection. New England Journal of Medicine 316:1366–1370
     [Google Scholar]
  173. Peden K., Mounts P., Hayward G. S. 1982; Homology between mammalian cell DNA sequences and human herpesvirus genomes detected by a hybridization procedure with high-complexity probe. Cell 31:71–80
     [Google Scholar]
  174. Pellett P., Jenkins F., Ackermann M., Sarmiento M., Roizman B. 1986; Transcription initiation sites and nucleotide sequences of a herpes simplex virus 1 gene conserved in Epstein–Barr virus genome and reported to affect the transport of viral glycoproteins. Journal of Virology 60:1134–1140
     [Google Scholar]
  175. Pereira L., Hoffman M., Tatsuno M., Dondero D. 1984; Polymorphism of human cytomegalovirus glycoproteins characterized by monoclonal antibodies. Virology 139:73–86
     [Google Scholar]
  176. Picard D., Schaffner W. 1984; A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene. Nature, London 307:80–82
     [Google Scholar]
  177. Pizzorno M. C., O’hare P., Sha L., LaFemina R. L., Hayward G. S. 1988; Trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus. Journal of Virology 62:1167–1179
     [Google Scholar]
  178. Plachter B., Traupe B., Albrecht J., Jahn G. 1988; Abundant 5 kb RNA of human cytomegalovirus without a major translational reading frame. Journal of General Virology 69:2251–2266
     [Google Scholar]
  179. Preston C. M. 1979; Abnormal properties of an immediate early polypeptide in cells infected with the herpes simplex virus type 1 mutant tsK. Journal of Virology 32:357–369
     [Google Scholar]
  180. Preston V. G. 1981; Fine-structure mapping of herpes simplex virus type 1 temperature-sensitive mutations within the short repeat region of the genome. Journal of Virology 39:150–161
     [Google Scholar]
  181. Rasmussen L., Nelson R., Kelsa U., Merigan T. 1984; Murine monoclonal antibody to a single protein neutralizes the infectivity of human cytomegalovirus. Proceedings of the National Academy of SciencesU.S.A 81:876–880
     [Google Scholar]
  182. Rasmussen L., Mullenax J., Nelson R., Merigan T. 1985a; Viral polypeptides detected by complement-dependent neutralizing murine monoclonal antibody to human cytomegalovirus. Journal of Virology 55:274–280
     [Google Scholar]
  183. Rasmussen R. D., Staprans S. I., Shaw S. B., Spector D. H. 1985b; Sequences in human cytomegalovirus which hybridize with the avian retrovirus oncogene v-myc are G + C rich and do not hybridize with the human c-myc gene. Molecular and Cellular Biology 5:1525–1530
     [Google Scholar]
  184. Rasmussen L., Nelson M., Neff M., Merigan T. C. 1988; Characterization of two different human cytomegalovirus glycoproteins which are targets for virus neutralizing antibody. Virology 163:308–318
     [Google Scholar]
  185. Re M. C., Landini M. P., Coppolecchia P., Furlini G., La placa M. 1985; A 28000 molecular weight human cytomegalovirus structural polypeptide studied by means of a specific monoclonal antibody. Journal of General Virology 66:2507–2511
     [Google Scholar]
  186. Robbins A. K., Dorney D. J., Wathen M. W., Whealy M. E., Gold C., Watson R. J., Holland L. E., Weed S. D., Levine M., Glorioso J. C., Enquist L. W. 1987; The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus. Journal of Virology 61:2691–2701
     [Google Scholar]
  187. Roby C., Gibson W. 1986; Characterization of phosphoproteins and protein kinase activity of virions, non-infectious enveloped particles, and dense bodies of human cytomegalovirus. Journal of Virology 59:714–727
     [Google Scholar]
  188. Roche J. K., Cheung K.-S., Boldogh I., Huang E-S., Lang D. J. 1981; Cytomegalovirus: detection in human colonic and circulating mononuclear cells in association with gastrointestinal disease. International Journal of Cancer 27:659–667
     [Google Scholar]
  189. RüGer R., Fleckenstein B. 1985; Cytomegalovirus DNA in colorectal carcinoma tissues. Klinische Wochenschrift 63:405–408
     [Google Scholar]
  190. Rüger R., Bornkamm G. W., Fleckenstein B. 1984a; Human cytomegalovirus DNA sequences with homologies to the cellular genome. Journal of General Virology 65:1351–1364
     [Google Scholar]
  191. Rüger R., Colimon R., Fleckenstein B. 1984b; Search for DNA sequences in Kaposi’s sarcoma tissues with cloned probes. Antibiotics and Chemotherapy 32:43–47
     [Google Scholar]
  192. Rüger R., Burmester G. R., Kalden J. R., Bienzle U., Braun R., Safai B., Sterry W., Fleckenstein B. 1984c; Search for human cytomegalovirus DNA in Kaposi’s sarcomas and hematopoietic cells from homosexual men with AIDS or unexplained lymphadenopathy. In Acquired Immune Deficiency Syndrome, UCLA Symposia New Series 16 127–137 Gottlieb M. S., Groopman J. E. New York: Alan R. Liss;
     [Google Scholar]
  193. Rüger B., Klages S., Walla B., Albrecht J., Fleckenstein B., Tomlinson P., Barrell B. 1987; Primary structure and transcription of the genes coding for the two virion phosphoproteins pp65 and pp71 of human cytomegalovirus. Journal of Virology 61:446–453
     [Google Scholar]
  194. St. Jeor S. C., Albrecht T. B., Funk F., Rapp F. 1974; Stimulation of cellular DNA synthesis by human cytomegalovirus. Journal of Virology 13:353–362
     [Google Scholar]
  195. Sanford E. J., Geder L., Dagen J. E., Laychock A., Rohner T. J. jr, Rapp F. 1978; Humoral and cellular immune response of prostatic cancer patients to cytomegalovirus related antigens of cytomegalovirus- transformed human cells. Journal of Surgical Research 24:404
     [Google Scholar]
  196. Scholl B.-C., Von Hintzenstern J., Borisch B., Traupe B., Bröker M., Jahn G. 1988; Prokaryotic expression of immunogenic polypeptides of the large phosphoprotein (pp150) of human cytomegalovirus. Journal of General Virology 69:1195–1204
     [Google Scholar]
  197. Schuster V., Matz B., Wiegand H., Traub B., Kampa D., Neumann-Hafelin D. 1986; Detection of human cytomegalovirus in urine by DNA-DNA and RNA-DNA hybridization. Journal of Infectious Diseases 154:309–314
     [Google Scholar]
  198. Sen R., Baltimore D. 1986; Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705–716
     [Google Scholar]
  199. Shaw S. B., Rasmussen R. D., McDonough S. H., Staprans S. I., Vacquier J. P., Spector D. H. 1985; Cell-related sequences in the DNA genome of human cytomegalovirus strain AD169. Journal of Virology 55:843–848
     [Google Scholar]
  200. Silver B. J., Bokar J. A., Virgin J. B., Vallen E. A., Milsted A., Nilson J. H. 1987; Cyclic AMP regulation of the human glycoprotein hormone α-subunit gene is mediated by an 18 base-pair element. Proceedings of the National Academy of SciencesU.S.A 84:2198–2202
     [Google Scholar]
  201. Spaete R. R., Mocarski E. S. 1985; The a sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes. Journal of Virology 54:817–824
     [Google Scholar]
  202. Spaete R. R., Thayer R. M., Probert W. S., Masiarz F. R., Chamberlain S. H., Rasmussen L., Merigan T. C., Pachl C. 1988; Human cytomegalovirus strain Towne glycoprotein B is processed by proteolytic cleavage. Virology 167:207–255
     [Google Scholar]
  203. Spector D. H., Vacquier J. P. 1983; Human cytomegalovirus (strain AD169) contains sequences related to the avian retrovirus oncogene v-myc. Proceedings of the National Academy of SciencesU.S.A 80:3889–3893
     [Google Scholar]
  204. Spector D. H., Hock L., Tamashiro J. C. 1982; Cleavage maps for human cytomegalovirus DNA strain AD169 for restriction endonucleases EcoRI, BglII, HindIII. Journal of Virology 42:558–582
     [Google Scholar]
  205. Spector D. J., Tevethia M. J. 1986; Identification of a human cytomegalovirus virus DNA segment that complements an adenovirus 5 immediate early mutant. Virology 151:329–338
     [Google Scholar]
  206. Spector S. A. 1983; Transmission of cytomegalovirus among infants in hospital documented by restriction- endonuclease-digestion analyses. Lancet i:378–381
     [Google Scholar]
  207. Spector S. A., Hirata K. K., Neuman T. R. 1984; Identification of multiple cytomegalovirus strains in homosexual men with acquired immunodeficiency syndrome. Journal of Infectious Diseases 150:953–955
     [Google Scholar]
  208. Spector S. A., Neuman T. R., Hirata K. K. 1985; Rapid determination of molecular relatedness of isolates of human cytomegalovirus. Journal of Infectious Diseases 152:755–759
     [Google Scholar]
  209. Stagno S., Whitley R. J. 1985; Herpesvirus infections of pregnancy. Part I: Cytomegalovirus and Epstein- Barr virus infections. New England Journal of Medicine 313:1270–1274
     [Google Scholar]
  210. Stagno S., Tinker M. K., Elrod C., Fuccillo D. A., Cloud G., O’beirne A. J. 1985; Immunoglobulin M antibodies detected by enzyme-linked immunosorbent assay and radioimmunoassay in the diagnosis of cytomegalovirus infections in pregnant women and newborn infants. Journal of Clinical Microbiology 21:930–935
     [Google Scholar]
  211. Staprans S. I., Spector D. H. 1986; 2·2-kilobase class of early transcripts encoded by cell-related sequences in human cytomegalovirus strain AD169. Journal of Virology 57:591–602
     [Google Scholar]
  212. Stenberg R. M., Stinski M. F. 1985; Autoregulation of the human cytomegalovirus major immediate early gene. Journal of Virology 56:676–682
     [Google Scholar]
  213. Stenberg R. M., Thomsen D. R., Stinski M. F. 1984; Structural analysis of the major immediate early gene of human cytomegalovirus. Journal of Virology 49:190–199
     [Google Scholar]
  214. Stenberg R. M., Witte P. R., Stinski M. F. 1985; Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1. Journal of Virology 56:665–675
     [Google Scholar]
  215. Stinski M. F. 1977; Synthesis of proteins and glycoproteins in cells infected with human cytomegalovirus. Journal of Virology 23:751–767
     [Google Scholar]
  216. Stinski M. F. 1978; Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides. Journal of Virology 26:686–701
     [Google Scholar]
  217. Stinski M. F., Roehr T. J. 1985; Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virus-specific trans-acting components. Journal of Virology 55:431–441
     [Google Scholar]
  218. Stinski M. F., Thomsen D. R., Stenberg R. M., Goldstein L. C. 1983; Organization and expression of the immediate early genes of human cytomegalovirus. Journal of Virology 46:1–14
     [Google Scholar]
  219. Sutherland S., Crawford D. H., Wilson S. A., Morgan B., Azim T., Heuhns E. R. 1987; Production and characterization of a human monoclonal antibody to cytomegalovirus and its use in an early nuclear fluorescence assay. Journal of Medical Virology 22:245–255
     [Google Scholar]
  220. Swenson P. D., Kaplan M. H. 1985; Rapid detection of cytomegalovirus in cell culture by indirect immunoperoxidase staining with monoclonal antibody to an early nuclear antigen. Journal of Clinical Microbiology 21:669–673
     [Google Scholar]
  221. Tamashiro J. C., Spector D. H. 1986; Terminal structure and heterogeneity in human cytomegalovirus strain AD169. Journal of Virology 59:591–604
     [Google Scholar]
  222. Tamashiro J. C., Filpula D., Friedmann T., Spector D. H. 1984; Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169 DNA. Journal of Virology 52:541–548
     [Google Scholar]
  223. Tevethia M. J., Spector D. J., Leisure K. M., Stinski M. F. 1987; Participation of two human cytomegalovirus immediate early gene regions in transcriptional activation of adenovirus promoters. Virology 161:276–285
     [Google Scholar]
  224. Thiele G. M., Bicak M. S., Young A., Kinsey J., White R. J., Purtilo D. T. 1987; Rapid detection of cytomegalovirus by tissue culture, centrifugation, and immunofluorescence with a monoclonal antibody to an early nuclear antigen. Journal of Virological Methods 16:327–338
     [Google Scholar]
  225. Thomsen D. R., Stinski M. F. 1981; Cloning of the human cytomegalovirus genome as endonuclease XbaI fragments. Gene 16:207–216
     [Google Scholar]
  226. Thomsen D. R., Stenberg R. M., Goins W. F., Stinski M. F. 1984; Promoter-regulatory region of the major immediate early gene of human cytomegalovirus. Proceedings of the National Academy of SciencesU.S.A 81:659–663
     [Google Scholar]
  227. Virtanen M., Syvänen A.-C., Oram J., Soderlund H., Ranki M. 1984; Cytomegalovirus in urine: detection of viral DNA by sandwich hybridization. Journal of Clinical Microbiology 26:1083–1088
     [Google Scholar]
  228. Volpi A., Whitley R. J., Ceballos R., Stagno S. 1983; Rapid diagnosis of pneumonia due to cytomegalovirus with specific monoclonal antibodies. Journal of Infectious Diseases 147:1119–1120
     [Google Scholar]
  229. Vonsover A., Gotlieb-Stematsky T., Sayer Y., Barov L., Manor Y., Siegal B. 1987; Detection of CMV in urine: comparison between DNA-DNA hybridization, virus isolation, and immuno-electron microscopy. Journal of Virological Methods 16:29–37
     [Google Scholar]
  230. Wathen M. W., Stinski M. F. 1982; Temporal patterns of human cytomegalovirus transcription: mapping the viral RNAs synthesized at immediate early, early, and late times after infection. Journal of Virology 41:462–477
     [Google Scholar]
  231. Wathen M. W., Thomsen D. R., Stinski M. F. 1981; Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection. Journal of Virology 38:446–459
     [Google Scholar]
  232. Weber F., De Villiers J., Schaffner W. 1984; An SV40 ‘Enhancer Trap’ incorporates exogenous enhancers or generates enhancers from its own sequences. Cell 36:983–992
     [Google Scholar]
  233. Wertheim P. M. E., Voute P. A. 1976; Neuroblastoma, Wilms’ tumor, and cytomegalovirus. Journal of the National Cancer Institute 57:701–703
     [Google Scholar]
  234. Weston K. 1988; An enhancer element in the short unique region of human cytomegalovirus regulates the production of a group of abundant immediate early transcripts. Virology 162:406–416
     [Google Scholar]
  235. Weston K., Barrell B. G. 1986; Sequence of the short unique region, short repeats, and part of the long repeats of human cytomegalovirus. Journal of Molecular Biology 192:177–208
     [Google Scholar]
  236. Weststrate M. W., Geelen J. L. M. C., Van Der Noordaa J. 1980; Human cytomegalovirus DNA: physical maps for the restriction endonucleases BglII, HindIII and XbaI. Journal of General Virology 49:1–21
     [Google Scholar]
  237. Eststrate M. W., Geelen J. L. M. C., Wertheim P. M. E., Van der noordaa J. 1983; Comparison of the physical maps of the DNAs of two cytomegalovirus strains. Journal of General Virology 64:47–55
     [Google Scholar]
  238. Wiley C. A., Schrier R. D., Denaro F. J., Nelson J. A., Lampert P. W., Oldstone M. B. A. 1986; Localization of cytomegalovirus proteins and genome during fulminant central nervous systemic infection in an AIDS patient. Journal of Neuropathology and Experimental Neurology 45:127–139
     [Google Scholar]
  239. Wilkinson G. W. G., Akrigg A., Greenaway P. J. 1984; Transcription of the immediate early genes of human cytomegalovirus strain AD169. Virus Research 1:101–116
     [Google Scholar]
  240. Wright D. A., Staprans S. I., Spector D. H. 1988; Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169. Journal of Virology 62:331–340
     [Google Scholar]
  241. Wroblewska Z., Gilden D., Devlin M., Huang E-S., Rorke L. B., Hamada T., Furukawa R., Cummins L., Kalter S., Koprowski H. 1979; Cytomegalovirus isolation from a chimpanzee with acute demyelinating disease after inoculation of multiple sclerosis brain cells. Infection and Immunity 25:1008–1015
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-70-12-3117
Loading
Human Cytomegalovirus: Recent Aspects from Molecular Biology
J. Gen. Virol. 70, 3117 (1989); https://doi.org/10.1099/0022-1317-70-12-3117
/content/journal/jgv/10.1099/0022-1317-70-12-3117
/content/journal/jgv/10.1099/0022-1317-70-12-3117
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error