1887

Journal of General Virology header logo

Volume 74, Issue 9

Nucleotide and predicted amino acid sequences of Marek′s disease virus homologues of herpes simplex virus major tegument proteins Free

Abstract

The DNA sequence of an 8.4 kbp HI-RI fragment of Marek′s disease virus (MDV) strain GA was determined. Three of the predicted polypeptides are homologous to UL47, UL48 and UL49 encoding the major tegument proteins of herpes simplex virus type 1 (HSV-1), and four are homologous to HSV-1 UL45, UL46, UL49.5 and UL50. These seven genes are found in the long unique region of the MDV genome and are collinear with homologues in HSV-1 and varicellα-zoster virus (VZV). Northern blot analysis revealed different transcriptional patterns from those of HSV-1 and VZV. MDV homologues of UL49.5, UL49 and UL47 lack a poly(A) signal immediately downstream of their coding regions. Amino acid conservation between MDV and HSV-1, and between MDV and VZV is as high as that between HSV-1 and VZV. The MDV homologue of UL48 shows 60% similarity to its HSV-1 counterpart. Amino acid sequence comparison reveals that the MDV homologue of UL48 lacks an acidic carboxyl terminus. This homologue, like the VZV homologue of UL48, may be involved in the trans-activation of immediate early genes and may function as an important component of the structural proteins.

  • Received:
  • Accepted:
  • Published Online:
© Society for General Microbiology 1993
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-74-9-1837
1993-09-01
2024-05-01
Loading full text...

Full text loading...

/deliver/fulltext/jgv/74/9/JV0740091837.html?itemId=/content/journal/jgv/10.1099/0022-1317-74-9-1837&mimeType=html&fmt=ahah

References

  1. Ace CI, McKee TA, Ryan JM, Cameron JM, Preston CM. 1989; Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression.. Journal of Virology 63:2260–2269
     [Google Scholar]
  2. Barker DE, Roizman B. 1992; The unique sequence of the herpes simplex virus-1 L component contains an additional translated open reading frame designated UL49∙5.. Journal of Virology 66:562–566
     [Google Scholar]
  3. Barnett BC, Dolan A, Telford EAR, Davison AJ, McGeoch DJ. 1992; A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses.. Journal of General Virology 73:2167–2171
     [Google Scholar]
  4. Buckmaster AE, Scott SD, Sanderson MJ, Boursnell MEG, Ross LJN, Binns MM. 1988; Gene sequence and mapping data from Marek’s disease virus and herpesvirus of turkeys: implications for herpesvirus classification.. Journal of General Virology 69:2033–2042
     [Google Scholar]
  5. Campbell MEM, Palfreyman JW, Preston CM. 1984; Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription.. Journal of Molecular Biology 180:1–199
     [Google Scholar]
  6. Chodosh LA, Baldwin AS, Carthew RW, Sharp PA. 1988; Human CCAAT-binding proteins have heterologous subunits.. Cell 53:11–24
     [Google Scholar]
  7. Corden J, Wasylyk B, Buchwalder A, Sassone-Corsi P, Kedinger C, Chambon P. 1980; Promoter sequences of eukaryotic protein-coding genes.. Science 209:1406–1414
     [Google Scholar]
  8. Coussens PM, Velicer LF. 1988; Structure and complete nucleotide sequence of the Marek’s disease herpesvirus gp57-65 gene.. Journal of Virology 62:2373–2379
     [Google Scholar]
  9. Davison AJ, Scott JE. 1986; The complete DNA sequence of varicellα-zoster virus.. Journal of General Virology 67:1759–1816
     [Google Scholar]
  10. Devereux J, Haeberli P, Smithies O. 1984; A comprehensive set of sequence analysis programs for the VAX.. Nucleic Acids Research 12:387–395
     [Google Scholar]
  11. Eidson CS, Schmittle SC. 1968; Studies on acute Marek’s disease. I. Characteristics of isolate GA in chickens.. Avian Diseases 12:467–476
     [Google Scholar]
  12. Elliott GD, Meredith DM. 1992; The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49.. Journal of General Virology 73:723–726
     [Google Scholar]
  13. Fukuchi K, Sudo M, Lee YS, Tanaka A, Nonoyama M. 1984; Structure of Marek’s disease virus DNA: detailed restriction enzyme map.. Journal of Virology 51:102–109
     [Google Scholar]
  14. Gonnet GH, Cohen MA, Benner SA. 1992; Exhaustive matching of the entire protein sequence database.. Science 256:1443–1445
     [Google Scholar]
  15. Greaves R, O’Hare P. 1989; Separation of requirements for protein-DNA complex assembly from those for functional activity in the herpes simplex virus regulatory protein Vmw65.. Journal of Virology 63:1641–1650
     [Google Scholar]
  16. Henikoef S. 1984; Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.. Gene 28:351–359
     [Google Scholar]
  17. Honess RW, Roizman B. 1973; Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and nonstructural herpes virus polypeptides in the infected cell.. Journal of Virology 12:1347–1365
     [Google Scholar]
  18. Honess RW, Roizman B. 1974; Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.. Journal of Virology 14:8–19
     [Google Scholar]
  19. Ihara DE, Kato A, Ueda S, Ishihama A, Hirai K. 1989; Comparison of the sequence of the secretory glycoprotein A (gA) gene in Md5 and BC-1 strains of Marek’s disease virus type 1.. Virus Genes 3:127–140
     [Google Scholar]
  20. Lemastbr S, Roizman B. 1980; Herpes simplex virus phospho-proteins II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion.. Journal of Virology 35:798–811
     [Google Scholar]
  21. McGeoch DJ, Dalrymple MA, Davison AJ, Dolan A, Frame MC, McNab D, Perry LJ, Scott JE, Taylor P. 1988; The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.. Journal of General Virology 69:1531–1574
     [Google Scholar]
  22. McKee TA, Disney GH, Everett RD, Preston CM. 1990; Control of expression of the varicellα-zoster virus major immediate early gene.. Journal of General Virology 71:897–906
     [Google Scholar]
  23. McKnight JLC, Pellett PE, Jenkins FJ, Roizman B. 1987; Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate α-lranr-inducing factor-dependent activation of a genes.. Journal of Virology 61:992–1001
     [Google Scholar]
  24. McLauchlan J, Gaffney D, Whitton JL, Clements JB. 1985; The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini.. Nucleic Acids Research 13:1347–1368
     [Google Scholar]
  25. McLean G, Rixon F, Langeland N, Haarr L, Marsden H. 1990; Identification and characterization of the virion protein products of herpes simplex virus type 1 gene UL47.. Journal of General Virology 71:2953–2960
     [Google Scholar]
  26. McNabb DS, Courtney RJ. 1992; Identification and characterization of the herpes simplex virus type 1 virion protein encoded by the UL35 open reading frame.. Journal of Virology 66:2653–2663
     [Google Scholar]
  27. Moriuchi H, Moriuchi M, Straus SE, Cohen JI. 1993; Varicellα-zoster virus open reading frame 10 protein, the herpes simplex virus VP 16 homolog, transactivates herpesvirus immediate-early gene promoters.. Journal of Virology 67:2739–2746
     [Google Scholar]
  28. O’Hare P, Hayward GS. 1985; Three irons-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation.. Journal of Virology 56:723–733
     [Google Scholar]
  29. Preston CM, Cordingley MG, Stow ND. 1984; Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene.. Journal of Virology 50:708–718
     [Google Scholar]
  30. Preston VG, Fisher FB. 1984; Identification of the herpes simplex virus type 1 gene encoding the dUTPase.. Virology 138:58–68
     [Google Scholar]
  31. Purewal AS, Smallwood AV, Kaushal A, Adegboye D, Edington N. 1992; Identification and control of the cis-acting elements of the immediate early gene of equid herpesvirus type 1.. Journal of General Virology 73:513–519
     [Google Scholar]
  32. Roizman B, Desrosiers RC, Fleckenstein B, Lopez C, Minson AC, Studdert MJ. 1992; The family Herpesviridae: an update.. Archives of Virology 123:425–449
     [Google Scholar]
  33. Ross LJN, Binns MM. 1991; Properties and evolutionary relationships of the Marek’s disease virus homologues of protein kinase, glycoprotein D and glycoprotein I of herpes simplex virus.. Journal of General Virology 72:939–947
     [Google Scholar]
  34. Sambrook J, Fritsch EF, Maniatis T. 1989 Molecular Cloning: A Laboratory Manual, 2nd edn.. New York: Cold Spring Harbor Laboratory.; p 7–19
     [Google Scholar]
  35. Singer VL, Wobbe CR, Struhl K. 1990; A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation.. Genes and Development 4:636–645
     [Google Scholar]
  36. Solomon JJ. 1975; Preparation of avian cell cultures.. Tissue Culture Association 1:7–11
     [Google Scholar]
  37. Spear PG, Roizman B. 1972; Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion.. Journal of Virology 9:143–159
     [Google Scholar]
  38. Telford EAR, Watson MS, McBride K, Davison AJ. 1992; The DNA sequence of equine herpesvirus-1.. Virology 189:304–316
     [Google Scholar]
  39. Triezenberg SJ, Kingsbury RC, McKnight SL. 1988; Functional dissection of VP16, the transactivator of herpes simplex virus immediate early gene expression.. Genes and Development 2:718–729
     [Google Scholar]
  40. Weinheimer SP, Boyd BA, Durham SK, Resnick JL, O’Boyle DR. 1992; Deletion of the VP16 open reading frame of herpes simplex virus type-1.. Virology 66:258–269
     [Google Scholar]
  41. Whittaker GR, Riggio MP, Halliburton IW, Killington RA, Allen GP, Meredith DM. 1991; Antigenic and protein sequence homology between VP13/14, a herpes simplex virus type-1 tegument protein, and gplO, a glycoprotein of equine herpesvirus 1 and 4.. Journal of Virology 65:2320–2326
     [Google Scholar]
  42. Wiley SR, Kraus RJ, Mertz JE. 1992; Functional binding of the ‘TATA’ box binding component of transcription factor TFIID to the -30 region of TATA-less promoters.. Proceedings of the National Academy of Sciences, U.S.A. 89:5814–5818
     [Google Scholar]
  43. Zhang Y, Sirko DA, McKnight ILC. 1991; Role of herpes simplex virus type-1 UL46 and UL47 in aTJF-mediated transcriptional induction: characterization of three viral deletion mutants.. Journal of Virology 65:829–841
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-74-9-1837
Loading
Nucleotide and predicted amino acid sequences of Marek′s disease virus homologues of herpes simplex virus major tegument proteins
J. Gen. Virol. 74, 1837 (1993); https://doi.org/10.1099/0022-1317-74-9-1837
/content/journal/jgv/10.1099/0022-1317-74-9-1837
/content/journal/jgv/10.1099/0022-1317-74-9-1837
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error