f Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a
- Authors: Minoru Sakamoto, Yoshihiro Akahane, Fumio Tsuda, Takeshi Tanaka, D. Graeme Woodfield, Hiroaki Okamoto
- J. Gen. Virol., July 1994 75: 1761-1768, doi: 10.1099/0022-1317-75-7-1761
- Subject: Animal
- Published Online:
The entire nucleotide sequence of a hepatitis C virus (HCV) genome (NZL1) of genotype V/3a was determined from overlapping cDNA clones obtained from a human carrier in New Zealand. It comprised 9425 nucleotides (nt) including a 5′-untranslated region of 339 nt, a single large open reading frame encoding a polyprotein of 3021 amino acids, a 3′-untranslated region of 23 nt, and 3′-terminal poly(U) stretches of variable lengths. The NZL1 genome was compared with 15 HCV isolates of other genotypes for which the full-length sequence has been determined. It differed from them by 31.1 to 34.3% in nucleotide sequence identity and by 24.5 to 29.1% in amino acid sequence identity, confirming the distinction of genotype V/3a from the other isolates.
© Society for General Microbiology 1994 | Published by the Microbiology Society
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