1887

Abstract

The similarity in histopathological changes seen in scrapie-infected mice and in an uninfected senescence-accelerated mouse strain led to a study in which the mouse strain that is prone to senescence (SAMP8), a strain that is resistant to senescence (SAMR1) and a progenitor strain (AKR) of these two strains were infected with three different scrapie strains, ME7,139Aand 22L. For each scrapie strain, the incubation period was shortest in AKR mice and longest in SAMR1 mice. The induction of obesity was a function of scrapie strain and not mouse strain; ME7 caused obesity in all mouse strains, whereas the average weights of mice injected with 139A and 22L did not differ significantly from mice injected with homogenates of normal mouse brain. The pattern of vacuolation seen in the brain of each mouse strain was primarily dependent on the scrapie strain injected. There were, in general, similarities to the patterns induced in other inbred strains; e.g. ME7 caused extensive forebrain vacuolation, 22L caused prominent vacuolation in the cerebellum, and the 139A strain induced characteristic white matter vacuolation. Vacuolation was also seen inthe medulla and midbrain of SAMP8 mice injected with normal mouse brain, which is consistent with the occurrence of accelerated ageing changes in the brain of this strain. Further analysis of the differences among these mouse strains should provide information relating to the observed differences in scrapie incubation periods.

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1998-11-01
2024-05-10
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References

  1. Akiguchi I., Yagi H., Ueno M., Takemura M., Kitabayashi T., Seriu N., Kawamata T., Nakamura S., Shimada A., Takeda T. 1994; Age related morphological changes in the brain of senescence-accelerated mouse (SAMP8). In The SAM Model of Senescence, Proceedings of the First International Conference on Senescence pp. 67–72 Takeda T. Edited by Amsterdam: Elsevier;
    [Google Scholar]
  2. Beck E., Daniel P. M., Parry H. B. 1964; Degeneration of the cerebellar and hypothalamic neurohypophysial systems in sheep with scrapie and its relationship to human system degenerations. Brain 87:153–176
    [Google Scholar]
  3. Bruce M. E., Dickinson A. G., Fraser H. 1976; Cerebral amyloidosis in scrapie in the mouse, effect of agent strain and mouse genotype. Neuropathology and Applied Neurobiology 2:471–478
    [Google Scholar]
  4. Carlson G. A., Kingsbury D. T., Goodman P. A., Coleman S., Marshall S. T., DeArmond S. J., Westaway D., Prusiner S. B. 1986; Prion protein and scrapie incubation time genes are linked. Cell 46:503–511
    [Google Scholar]
  5. Carp R. I., Callahan S. M. 1986; Scrapie incubation periods and endpoint titers in mouse strains differing at the H-2D locus. Intervirology 26:85–92
    [Google Scholar]
  6. Carp R. I., Rubenstein R. 1991; Diversity and significance of scrapie strains. Seminars in Virology 2:203–213
    [Google Scholar]
  7. Carp R. I., Callahan S. M., Sersen E. A., Moretz R. C. 1984; Preclinical changes in weight of scrapie-infected mice as a function of scrapie agent-mouse strain combination. Intervirology 21:61–69
    [Google Scholar]
  8. Carp R. I., Moretz R. C., Natelli M., Dickinson A. G. 1987; Genetic control of scrapie: incubation period and plaque formation in I mice. Journal of General Virology 68:401–407
    [Google Scholar]
  9. Carp R. I., Kim Y. S., Kascsak R. J., Merz P. A., Rubenstein R. 1989; Classic genetics of scrapie. In Alzheimer’s Disease and Related Disorders pp. 567–582 Iqbal K., Wisniewski H. M., Winblad B. Edited by New York: Alan R. Liss;
    [Google Scholar]
  10. Carp R. I., Meeker H., Sersen E. 1997; Scrapie strains retain their distinctive characteristics following passages of homogenates from different brain regions and spleen. Journal of General Virology 78:283–290
    [Google Scholar]
  11. Dickinson A. G., Fraser H. 1979; An assessment of the genetics of scrapie in sheep and mice. In Slow Transmissible Diseases of the Nervous System 1 pp. 367–385 Prusiner S. B., Hadlow W. J. Edited by New York: Academic Press;
    [Google Scholar]
  12. Dickinson A. G., Meikle V. M. H. 1969; A comparison of some biological characteristics of the mouse-passaged scrapie agents, 22A and ME7. Genetic Research 13:213–225
    [Google Scholar]
  13. Dickinson A. G., Bruce M. E., Fraser H., Kimberlin R. H. 1984; Scrapie strain differences: the implication of stability and mutation. In Proceedings of Workshop on Slow Transmissible Diseases pp. 105–118 Tateishi J. Edited by Tokyo: Japanese Ministry of Health and Welfare;
    [Google Scholar]
  14. Flood J. F., Morley J. E. 1994; Studies on genetic aspects on impaired learning and memory in SAMP8 mice. In The Sam Model of Senescence, Proceedings of the First International Conference on Senescence pp. 405–408 Takeda T. Edited by Amsterdam: Elsevier;
    [Google Scholar]
  15. Flood J. F., Morley J. E. 1998; Learning and memory in the SAMP8 mouse. Neuroscience and Biobehavioral Reviews 22:1–20
    [Google Scholar]
  16. Flood J. F., Morley P. M. K., Morley J. E. 1995; Age-related changes in learning, memory, and lipofuscin as a function of the percentage of SAMP8 genes. Physiology & Behavior 58:819–822
    [Google Scholar]
  17. Fraser H. 1979; Neuropathology of scrapie: the precision of the lesions and their diversity. In Slow Transmissible Diseases of the Nervous System 1 pp. 387–406 Prusiner S. B., Hadlow W. J. Edited by New York: Academic Press;
    [Google Scholar]
  18. Fraser H., Dickinson A. G. 1973; Agent-strain differences in the distribution and intensity of grey matter vacuolation. Journal of Comparative Pathology 83:29–40
    [Google Scholar]
  19. Jendroska K., Heinzel F. P., Torchia M., Stowring L., Kretzschmar H. A., Kon A., Stern A., Prusiner S. B., DeArmond S. J. 1991; Proteinase-resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity. Neurology 41:1482–1490
    [Google Scholar]
  20. Kascsak R. J., Rubenstein R., Merz P. A., Carp R. I., Robakis N. K., Wisniewski H. M., Diringer H. 1986; Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. Journal of Virology 59:676–683
    [Google Scholar]
  21. Kim Y. S., Carp R. I., Callahan S. M., Wisniewski H. M. 1987a; Incubation periods and survival times for mice injected stereotaxically with three scrapie strains in different brain regions. Journal of General Virology 68:695–702
    [Google Scholar]
  22. Kim Y. S., Carp R. I., Callahan S. M., Wisniewski H. M. 1987b; Scrapie-induced obesity in mice. Journal of Infectious Diseases 156:402–405
    [Google Scholar]
  23. Kim Y. S., Carp R. I., Callahan S. M., Wisniewski H. M. 1988; Adrenal involvement in scrapie-induced obesity. Proceedings of the Society for Experimental Biology and Medicine 189:21–27
    [Google Scholar]
  24. Kim Y. S., Carp R. I., Callahan S. M., Natelli M., Wisniewski H. M. 1990; Vacuolization, incubation period and survival time analyses in three mouse genotypes injected stereotactically in three brain regions with the 22L scrapie strain. Journal of Neuropathology and Experimental Neurology 49:106–113
    [Google Scholar]
  25. Kingsbury D. T., Kasper K. C., Stites D. P., Watson J. D., Hogan R. N., Prusiner S. B. 1983; Genetic control of scrapie and Creutzfeldt-Jakob disease in mice. Journal of Immunology 131:491–496
    [Google Scholar]
  26. Meeker H. C., Carp R. I. 1997; Titers of murine leukemia virus are higher in brains of SAMP8 than SAMR1 mice. Neurobiology of Ageing 18:543–547
    [Google Scholar]
  27. Miyamoto M., Kiyota Y., Yamazaki N., Nagaoka A., Matsuo T., Nagawa Y., Takeda T. 1986; Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Physiology and Behavior 38:399–406
    [Google Scholar]
  28. Scott J. R., Fraser H. 1984; Degenerative hippocampal pathology in mice infected with scrapie. Acta Neuropathology 65:62–68
    [Google Scholar]
  29. Sidman R. L., Angevine J. B. Jr Pierce E. T. 1971 Atlas of the Mouse Brain and Spinal Cord Harvard: Harvard University Press;
    [Google Scholar]
  30. Takeda T., Hosokawa M., Higuchi K. 1991; Senescence-accelerated mouse (SAM) : a novel murine model of accelerated senescence. Journal of the American Geriatric Society 59:911–919
    [Google Scholar]
  31. Takeda T., Hosokawa M., Higuchi K. 1994; Senescence accelerated mouse (SAM). A novel murine model of ageing. In The SAM Model of Senescence, Proceedings of the First International Conference on Senescence pp. 15–22 Takeda T. Edited by Amsterdam: Elsevier;
    [Google Scholar]
  32. Takeda T., Hosokawa M., Higuchi K. 1997a; Senescence-accelerated mouse (SAM) : a novel murine model of senescence. Experimental Gerontology 32:105–109
    [Google Scholar]
  33. Takeda T., Matsushita T., Kurozumi M., Takemura K., Higuchi K., Hosokawa M. 1997b; Pathobiology of the senescence-accelerated mouse (SAM). Experimental Gerontology 32:117–127
    [Google Scholar]
  34. Yagi H., Irino M., Matsushita T., Seika K., Umezawa M., Tsuboyama T., Hosokawa M., Akiguchi I., Tokunaga R., Takeda T. 1989; Spontaneous spongy degeneration of the brain stem in SAM-P/8 mice, a newly developed memory deficient strain. Journal of Neuropathology and Experimental Neurology 48:577–590
    [Google Scholar]
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