1887

Abstract

The identification of transmission routes for bluetongue virus (BTV) is essential to improve the control of the disease. Although BTV is primarily transmitted by several species of biting midges, there has been evidence of transplacental and oral transmission. We now report that IFNAR mice are susceptible to oral infection by BTV-8. Viraemia, clinical manifestations and tissue lesions are similar to those in intravenously infected mice. In addition, we show that the oral cavity and oesophagus are susceptible to BTV infection and replication, suggesting that these organs are possible entry routes during BTV oral infection.

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2010-11-01
2024-04-27
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References

  1. Alexander, K. A., MacLachlan, N. J., Kat, P. W., House, C., O'Brien, S. J., Lerche, N. W., Sawyer, M., Frank, L. G., Holekamp, K. & other authors(1994). Evidence of natural bluetongue virus infection among African carnivores. Am J Trop Med Hyg 51, 568–576. [Google Scholar]
  2. Backx, A., Heutink, R., Van Rooij, E. & Van Rijn, P.(2009). Transplacental and oral transmission of wild-type bluetongue virus serotype 8 in cattle after experimental infection. Vet Microbiol 138, 235–243.[CrossRef] [Google Scholar]
  3. Barratt-Boyes, S. M. & MacLachlan, N. J.(1994). Dynamics of viral spread in bluetongue virus infected calves. Vet Microbiol 40, 361–371.[CrossRef] [Google Scholar]
  4. Barratt-Boyes, S. M. & MacLachlan, N. J.(1995). Pathogenesis of bluetongue virus infection of cattle. J Am Vet Med Assoc 206, 1322–1329. [Google Scholar]
  5. Calvo-Pinilla, E., Rodriguez-Calvo, T., Anguita, J., Sevilla, N. & Ortego, J.(2009a). Establishment of a bluetongue virus infection model in mice that are deficient in the alpha/beta interferon receptor. PLoS ONE 4, e5171.[CrossRef] [Google Scholar]
  6. Calvo-Pinilla, E., Rodriguez-Calvo, T., Sevilla, N. & Ortego, J.(2009b). Heterologous prime boost vaccination with DNA and recombinant modified vaccinia virus Ankara protects IFNAR(−/−) mice against lethal bluetongue infection. Vaccine 28, 437–445.[CrossRef] [Google Scholar]
  7. De Clercq, K., Vandenbussche, F., Vandemeulebroucke, E., Vanbinst, T., De Leeuw, I., Verheyden, B., Goris, N., Mintiens, K., Meroc, E. & other authors(2008). Transplacental bluetongue infection in cattle. Vet Rec 162, 564. [Google Scholar]
  8. Desmecht, D., Bergh, R. V., Sartelet, A., Leclerc, M., Mignot, C., Misse, F., Sudraud, C., Berthemin, S., Jolly, S. & other authors(2008). Evidence for transplacental transmission of the current wild-type strain of bluetongue virus serotype 8 in cattle. Vet Rec 163, 50–52.[CrossRef] [Google Scholar]
  9. Hemati, B., Contreras, V., Urien, C., Bonneau, M., Takamatsu, H. H., Mertens, P. P., Breard, E., Sailleau, C., Zientara, S. & Schwartz-Cornil, I.(2009). Bluetongue virus targets conventional dendritic cells in skin lymph. J Virol 83, 8789–8799.[CrossRef] [Google Scholar]
  10. Jauniaux, T. P., De Clercq, K. E., Cassart, D. E., Kennedy, S., Vandenbussche, F. E., Vandemeulebroucke, E. L., Vanbinst, T. M., Verheyden, B. I., Goris, N. E. & Coignoul, F. L.(2008). Bluetongue in Eurasian lynx. Emerg Infect Dis 14, 1496–1498.[CrossRef] [Google Scholar]
  11. Jochim, M. M., Luedke, A. J. & Bowne, J. G.(1965). The clinical and immunogenic response of sheep to oral and intradermal administrations of bluetongue virus. Am J Vet Res 26, 1254–1260. [Google Scholar]
  12. MacLachlan, N. J., Jagels, G., Rossitto, P. V., Moore, P. F. & Heidner, H. W.(1990). The pathogenesis of experimental bluetongue virus infection of calves. Vet Pathol 27, 223–229. [Google Scholar]
  13. Maclachlan, N. J., Drew, C. P., Darpel, K. E. & Worwa, G.(2009). The pathology and pathogenesis of bluetongue. J Comp Pathol 141, 1–16.[CrossRef] [Google Scholar]
  14. Mahrt, C. R. & Osburn, B. I.(1986). Experimental bluetongue virus infection of sheep; effect of vaccination: pathologic, immunofluorescent, and ultrastructural studies. Am J Vet Res 47, 1198–1203. [Google Scholar]
  15. Menzies, F. D., McCullough, S. J., McKeown, I. M., Forster, J. L., Jess, S., Batten, C., Murchie, A. K., Gloster, J., Fallows, J. G. & other authors(2008). Evidence for transplacental and contact transmission of bluetongue virus in cattle. Vet Rec 163, 203–209.[CrossRef] [Google Scholar]
  16. Mertens, P. P. C., Maan, S., Samuel, A. & Attoui, H.(2004). Orbivirus, Reoviridae. In Virus Taxonomy, VIIIth Report of the ICTV, pp. 466–483. Edited by Fauquet, C. M., Mayo, M. A., Maniloff, J., Desselberger, U. & Ball, L. A.. London. : Elsevier/Academic Press. [Google Scholar]
  17. Sanchez-Cordon, P. J., Rodriguez-Sanchez, B., Risalde, M. A., Molina, V., Pedrera, M., Sanchez-Vizcaino, J. M. & Gomez-Villamandos, J. C.(2010). Immunohistochemical detection of bluetongue virus in fixed tissue. J Comp Pathol 143, 20–28.[CrossRef] [Google Scholar]
  18. Vercauteren, G., Miry, C., Vandenbussche, F., Ducatelle, R., Van der Heyden, S., Vandemeulebroucke, E., De Leeuw, I., Deprez, P., Chiers, K. & De Clercq, K.(2008). Bluetongue virus serotype 8-associated congenital hydranencephaly in calves. Transbound Emerg Dis 55, 293–298.[CrossRef] [Google Scholar]
  19. Verwoerd, D. W. & Erasmus, B. J.(2004). ). Bluetongue. In Infectious Diseases of Livestock, 2nd edn. Edited by Coetzer, J. A. W.. Oxford, UK. : Oxford University Press. [Google Scholar]
  20. Worwa, G., Hilbe, M., Chaignat, V., Hofmann, M. A., Griot, C., Ehrensperger, F., Doherr, M. G. & Thur, B.(2010). Virological and pathological findings in bluetongue virus serotype 8 infected sheep. Vet Microbiol 144, 264–273.[CrossRef] [Google Scholar]
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