The helper component-proteinase of the Zucchini yellow mosaic virus inhibits the Hua Enhancer 1 methyltransferase activity in vitro

References

1. Anandalakshmi R., Marathe R., Ge X., Herr J. M. Jr, Mau C., Mallory A., Pruss G., Bowman L., Vance V. B. 2000; A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants. Science 290:142–144 [View Article][PubMed]
   [Google Scholar]
2. Atreya C. D., Pirone T. P. 1993; Mutational analysis of the helper component-proteinase gene of a potyvirus: effects of amino acid substitutions, deletions, and gene replacement on virulence and aphid transmissibility. Proc Natl Acad Sci U S A 90:11919–11923 [View Article][PubMed]
   [Google Scholar]
3. Boutet S., Vazquez F., Liu J., Béclin C., Fagard M., Gratias A., Morel J. B., Crété P., Chen X., Vaucheret H. 2003; Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance. Curr Biol 13:843–848 [View Article][PubMed]
   [Google Scholar]
4. Csorba T., Bovi A., Dalmay T., Burgyán J. 2007; The p122 subunit of Tobacco mosaic virus replicase is a potent silencing suppressor and compromises both small interfering RNA- and microRNA-mediated pathways. J Virol 81:11768–11780 [View Article][PubMed]
   [Google Scholar]
5. Csorba T., Lózsa R., Hutvágner G., Burgyán J. 2010; Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1. Plant J 62:463–472 [View Article][PubMed]
   [Google Scholar]
6. Fang Y., Spector D. L. 2007; Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Curr Biol 17:818–823 [View Article][PubMed]
   [Google Scholar]
7. Fuellgrabe M. W., Boonrod K., Jamous R., Moser M., Shiboleth Y., Krczal G., Wassenegger M. 2011; Expression, purification and functional characterization of recombinant Zucchini yellow mosaic virus HC-Pro. Protein Expr Purif 75:40–45 [View Article][PubMed]
   [Google Scholar]
8. Horwich M. D., Li C., Matranga C., Vagin V., Farley G., Wang P., Zamore P. D. 2007; The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol 17:1265–1272 [View Article][PubMed]
   [Google Scholar]
9. Jin H., Zhu J. K. 2010; A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes. Genes Dev 24:853–856 [View Article][PubMed]
   [Google Scholar]
10. Kasschau K. D., Xie Z., Allen E., Llave C., Chapman E. J., Krizan K. A., Carrington J. C. 2003; P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction. Dev Cell 4:205–217 [View Article][PubMed]
    [Google Scholar]
11. Kirino Y., Mourelatos Z. 2007; 2′-O-methyl modification in mouse piRNAs and its methylase. Nucleic Acids Symp Ser (Oxf) 51:417–418 [View Article][PubMed]
    [Google Scholar]
12. Kurth H. M., Mochizuki K. 2009; 2′-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena.. RNA 15:675–685 [View Article][PubMed]
    [Google Scholar]
13. Laible M., Boonrod K. 2009; Homemade site directed mutagenesis of whole plasmids. J Vis Exp 27:pii 1135[PubMed]
    [Google Scholar]
14. Li J., Yang Z., Yu B., Liu J., Chen X. 2005; Methylation protects miRNAs and siRNAs from a 3′-end uridylation activity in Arabidopsis. Curr Biol 15:1501–1507 [View Article][PubMed]
    [Google Scholar]
15. Lózsa R., Csorba T., Lakatos L., Burgyán J. 2008; Inhibition of 3′ modification of small RNAs in virus-infected plants require spatial and temporal co-expression of small RNAs and viral silencing-suppressor proteins. Nucleic Acids Res 36:4099–4107 [View Article][PubMed]
    [Google Scholar]
16. Mérai Z., Kerényi Z., Kertész S., Magna M., Lakatos L., Silhavy D. 2006; Double-stranded RNA binding may be a general plant RNA viral strategy to suppress RNA silencing. J Virol 80:5747–5756 [View Article][PubMed]
    [Google Scholar]
17. Ramachandran V., Chen X. 2008a; Small RNA metabolism in Arabidopsis. Trends Plant Sci 13:368–374 [View Article][PubMed]
    [Google Scholar]
18. Ramachandran V., Chen X. 2008b ). Degradation of microRNAs by a family of exoribonucleases in Arabidopsis. Science 321:1490–1492 [View Article][PubMed]
    [Google Scholar]
19. Saito Y., Geisen P., Uppal A., Hartnett M. E. 2007; Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity. Mol Vis 13:840–853[PubMed]
    [Google Scholar]
20. Shiboleth Y. M., Haronsky E., Leibman D., Arazi T., Wassenegger M., Whitham S. A., Gaba V., Gal-On A. 2007; The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development. J Virol 81:13135–13148 [View Article][PubMed]
    [Google Scholar]
21. Silhavy D., Molnár A., Lucioli A., Szittya G., Hornyik C., Tavazza M., Burgyán J. 2002; A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs. EMBO J 21:3070–3080 [View Article][PubMed]
    [Google Scholar]
22. Wu H. W., Lin S. S., Chen K. C., Yeh S. D., Chua N. H. 2010; Discriminating mutations of HC-Pro of Zucchini yellow mosaic virus with differential effects on small RNA pathways involved in viral pathogenicity and symptom development. Mol Plant Microbe Interact 23:17–28 [View Article][PubMed]
    [Google Scholar]
23. Xie Z., Johansen L. K., Gustafson A. M., Kasschau K. D., Lellis A. D., Zilberman D., Jacobsen S. E., Carrington J. C. 2004; Genetic and functional diversification of small RNA pathways in plants. PLoS Biol 2:e104 [View Article][PubMed]
    [Google Scholar]
24. Yang Z., Ebright Y. W., Yu B., Chen X. 2006; HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2′ OH of the 3′ terminal nucleotide. Nucleic Acids Res 34:667–675 [View Article][PubMed]
    [Google Scholar]
25. Yu B., Yang Z., Li J., Minakhina S., Yang M., Padgett R. W., Steward R., Chen X. 2005; Methylation as a crucial step in plant microRNA biogenesis. Science 307:932–935 [View Article][PubMed]
    [Google Scholar]
26. Yu B., Chapman E. J., Yang Z., Carrington J. C., Chen X. 2006; Transgenically expressed viral RNA silencing suppressors interfere with microRNA methylation in Arabidopsis. FEBS Lett 580:3117–3120 [View Article][PubMed]
    [Google Scholar]