Dengue virus type 2 NS3 protease and NS2B-NS3 protease precursor induce apoptosis

References

1. Arias C. F., Preugschat F., Strauss J. H. 1993; Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain. Virology 193:888–899
   [Google Scholar]
2. Barco A., Feduchi E., Carrasco L. 2000; Poliovirus protease 3C^pro kills cells by apoptosis. Virology 266:352–360
   [Google Scholar]
3. Bartenschlager R., Ahlborn-Laake L., Yasargil K., Mous J., Jacobsen H. 1995; Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase. J Virol 69:198–205
   [Google Scholar]
4. Brinkworth R. I., Fairlie D. P., Leung D., Young P. R. 1999; Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor. J Gen Virol 80:1167–1177
   [Google Scholar]
5. Chambers T. J., Nestorowicz A., Amberg S. M., Rice C. M. 1993; Mutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication. J Virol 67:6797–6807
   [Google Scholar]
6. Clum S., Ebner K. E., Padmanabhan R. 1997; Cotranslational membrane insertion of the serine protease precursor NS2B-NS3(pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B. J Biol Chem 272:30715–30723
   [Google Scholar]
7. Couvelard A., Marianneau P., Bedel C., Drouet M. T., Vachon F., Henin D., Deubel V. 1999; Report of a fatal case of dengue infection with hepatitis: demonstration of dengue antigens in hepatocytes and liver apoptosis. Hum Pathol 9:1106–1110
   [Google Scholar]
8. Despres P., Flamand M., Ceccaldi P. E., Deubel V. 1996; Human isolates of dengue type 1 virus induce apoptosis in mouse neuroblastoma cells. J Virol 70:4090–4096
   [Google Scholar]
9. Du C., Fang M., Li Y., Li L., Wang X. 2000; Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33–42
   [Google Scholar]
10. Falgout B., Miller R. H., Lai C.-J. 1993; Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity. J Virol 67:2034–2042
    [Google Scholar]
11. Goldstaub D., Gradi A., Bercovitch Z., Grosmann Z., Nophar Y., Luria S., Sonenberg N., Kahana C. 2000; Poliovirus 2A protease induces apoptotic cell death. Mol Cell Biol 20:1271–1277
    [Google Scholar]
12. Hegde R., Srinivasula S. M., Zhang Z. J., Wassell R., Mukattash R., Cilenti L., DuBois G., Lazebnik Y., Zervos A. S., Fernandes-Alnemri T., Alnemri E. S. 2002; Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis proteins–caspase interaction. J Biol Chem 277:432–438
    [Google Scholar]
13. Henchal E. A., Putnak J. R. 1990; The dengue viruses. Clin Microbiol Rev 3:376–396
    [Google Scholar]
14. Huerre M. R., Lan N. T., Marianneau P. 9 other authors 2001; Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch 438:107–115
    [Google Scholar]
15. Jan L. R., Yang C. S., Trent D. W., Falgout B., Lai C. J. 1995; Processing of Japanese encephalitis virus non-structural proteins: NS2B-NS3 complex and heterologous proteases. J Gen Virol 76:573–580
    [Google Scholar]
16. Kolykhalov A. A., Agapov E. V., Rice C. M. 1994; Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing. J Virol 68:7525–7533
    [Google Scholar]
17. Lei H.-Y., Yeh T.-M., Liu H.-S., Lin Y.-S., Chen S.-H., Liu C.-C. 2001; Immunopathogenesis of dengue virus infection. J Biomed Sci 8:377–388
    [Google Scholar]
18. Li M.-L., Hsu T.-A., Chen T.-C., Chang S.-C., Lee J.-C., Chen C.-C., Stollar V., Shih S.-R. 2002; The 3C protease activity of enterovirus 71 induces human neural cell apoptosis. Virology 293:386–395
    [Google Scholar]
19. Marianneau P., Cardona A., Edelman L., Deubel V., Despres P. 1997; Dengue virus replication in human hepatoma cells activates NF- κ B which in turn induces apoptotic cell death. J Virol 71:3244–3249
    [Google Scholar]
20. Martins L. M., Iaccarino I., Tenev T. 8 other authors 2002; The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif. J Biol Chem 277:439–444
    [Google Scholar]
21. Prikhod'ko G. G., Prikhod'ko E. A., Pletnev A. G., Cohen J. I. 2002; Langat flavivirus protease NS3 binds caspase-8 and induces apoptosis. J Virol 76:5701–5710
    [Google Scholar]
22. Shafee N., AbuBakar S. 1997; Induction of apoptosis by dengue 2 (New Guinea C strain) virus infection in vitro . Asia Pac J Mol Biol Biotechnol 5:111–117
    [Google Scholar]
23. Shafee N., AbuBakar S. 1999; Inadvertent expression of dengue 2 virus NS3-EGFP fusion protein in Escherichia coli using the pEGFP-N1 mammalian expression vector. J Univ Malaya Med Center 4:42–46
    [Google Scholar]
24. Shafee N., AbuBakar S. 2002; Zinc accelerates dengue virus type 2-induced apoptosis in Vero cells. FEBS Lett 524:20–24
    [Google Scholar]
25. Srinivasula S. M., Datta P., Fan X. J., Fernandes-Alnemri T., Huang Z., Alnemri E. S. 2000; Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J Biol Chem 275:36152–36157
    [Google Scholar]
26. Srinivasula S. M., Hegde R., Saleh A. 8 other authors 2001; A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410:112–116
    [Google Scholar]
27. Verhagen A. M., Ekert P. G., Pakusch M., Silke J., Connolly L. M., Reid G. E., Moritz R. L., Simpson R. J., Vaux D. L. 2000; Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102:43–53
    [Google Scholar]
28. Verhagen A. M., Silke J., Ekert P. G. 10 other authors 2002; HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem 277:445–454
    [Google Scholar]
29. Yusof R., Clum S., Wetzel M., Murthy H. M. K., Padmanabhan R. 2000; Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro . J Biol Chem 275:9963–9969
    [Google Scholar]