1887

Journal of General Virology header logo

Volume 85, Issue 10

Cell-cycle dependence of foamy virus vectors Free

Abstract

Retroviruses differ in the extent to which they are dependent on host-cell proliferation for their replication, an aspect of their replication that impacts on their vector potential. Foamy viruses offer distinct advantages over other retroviruses for development as vectors for gene therapy. A vector derived from the prototypic foamy virus (PFV), formerly known as human foamy virus (HFV), transduced aphidicolin-arrested cells five- to tenfold more efficiently than one derived from murine leukemia virus (MLV), but several-fold less efficiently than a human immunodeficiency virus type 1 (HIV-1) vector. The same relative efficiency was found following transduction of cells that had been arrested by -irradiation or with mitomycin C. Cells that were exposed to vector during aphidicolin arrest and were subsequently allowed to cycle were transduced significantly better by PFV than by MLV. Quiescent human CD34 progenitor cells were transduced as efficiently by PFV as by HIV vectors (40–50 %) when transduction was assayed after the cells were allowed to cycle.

  • Received:
  • Accepted:
  • Published Online:
SGM
Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.80210-0
2004-10-01
2024-04-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/85/10/vir852925.html?itemId=/content/journal/jgv/10.1099/vir.0.80210-0&mimeType=html&fmt=ahah

References

  1. Bieniasz P. D., Weiss R. A., McClure M. O. 1995; Cell cycle dependence of foamy retrovirus infection. J Virol 69:7295–7299
     [Google Scholar]
  2. Bouyac-Bertoia M., Dvorin J. D., Fouchier R. A. M., Jenkins Y., Meyer B. E., Wu L. I., Emerman M., Malim M. H. 2001; HIV-1 infection requires a functional integrase NLS. Mol Cell 7:1025–1035 [CrossRef]
     [Google Scholar]
  3. Bukrinsky M. I., Haggerty S., Dempsey M. P. 7 other authors 1993; A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature 365:666–669 [CrossRef]
     [Google Scholar]
  4. Cosset F.-L., Takeuchi Y., Battini J.-L., Weiss R. A., Collins M. K. L. 1995; High-titer packaging cells producing recombinant retroviruses resistant to human serum. J Virol 69:7430–7436
     [Google Scholar]
  5. Cullen B. R. 2001; Journey to the center of the cell. Cell 105:697–700 [CrossRef]
     [Google Scholar]
  6. Erlwein O., Bieniasz P. D., McClure M. O. 1998; Sequences in pol are required for transfer of human foamy virus-based vectors. J Virol 72:5510–5516
     [Google Scholar]
  7. Fischer N., Heinkelein M., Lindemann D., Enssle J., Baum C., Werder E., Zentgraf H., Müller J. G., Rethwilm A. 1998; Foamy virus particle formation. J Virol 72:1610–1615
     [Google Scholar]
  8. Heinkelein M., Schmidt M., Fischer N., Moebes A., Lindemann D., Enssle J., Rethwilm A. 1998; Characterization of a cis -acting sequence in the pol region required to transfer human foamy virus vectors. J Virol 72:6307–6314
     [Google Scholar]
  9. Heinkelein M., Dressler M., Jármy G., Rammling M., Imrich H., Thurow J., Lindemann D., Rethwilm A. 2002; Improved primate foamy virus vectors and packaging constructs. J Virol 76:3774–3783 [CrossRef]
     [Google Scholar]
  10. Hirata R. K., Miller A. D., Andrews R. G., Russell D. W. 1996; Transduction of hematopoietic cells by foamy virus vectors. Blood 88:3654–3661
     [Google Scholar]
  11. Ikeda Y., Takeuchi Y., Martin F., Cosset F. L., Mitrophanous K., Collins M. 2003; Continuous high-titer HIV-1 vector production. Nat Biotechnol 21:569–572 [CrossRef]
     [Google Scholar]
  12. Imrich H., Heinkelein M., Herchenröder O., Rethwilm A. 2000; Primate foamy virus Pol proteins are imported into the nucleus. J Gen Virol 81:2941–2947
     [Google Scholar]
  13. Josephson N. C., Vassilopoulos G., Trobridge G. D., Priestley G. V., Wood B. L., Papayannopoulou T., Russell D. W. 2002; Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors. Proc Natl Acad Sci U S A 99:8295–8300 [CrossRef]
     [Google Scholar]
  14. Josephson N. C., Trobridge G., Russell D. W. 2004; Transduction of long-term and mobilized peripheral blood-derived NOD/SCID repopulating cells by foamy virus vectors. Hum Gene Ther 15:87–92 [CrossRef]
     [Google Scholar]
  15. Kotsopoulou E., Kim V. N., Kingsman A. J., Kingsman S. M., Mitrophanous K. A. 2000; A Rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimized HIV-1 gag - pol gene. J Virol 74:4839–4852 [CrossRef]
     [Google Scholar]
  16. Kozak M. 1986; Bifunctional messenger RNAs in eukaryotes. Cell 47:481–483 [CrossRef]
     [Google Scholar]
  17. Leurs C., Jansen M., Pollok K. E. 8 other authors 2003; Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Hum Gene Ther 14:509–519 [CrossRef]
     [Google Scholar]
  18. Mergia A., Chari S., Kolson D. L., Goodenow M. M., Ciccarone T. 2001; The efficiency of simian foamy virus vector type-1 (SFV-1) in nondividing cells and in human PBLs. Virology 280:243–252 [CrossRef]
     [Google Scholar]
  19. Mitrophanous K. A., Yoon S., Rohll J. B., Patil D., Wilkes F. J., Kim V. N., Kingsman S. M., Kingsman A. J., Mazarakis N. D. 1999; Stable gene transfer to the nervous system using a non-primate lentiviral vector. Gene Ther 6:1808–1818 [CrossRef]
     [Google Scholar]
  20. Muranyi W., Flügel R. M. 1991; Analysis of splicing patterns of human spumaretrovirus by polymerase chain reaction reveals complex RNA structures. J Virol 65:727–735
     [Google Scholar]
  21. Pietschmann T., Heinkelein M., Heldmann M., Zentgraf H., Rethwilm A., Lindemann D. 1999; Foamy virus capsids require the cognate envelope protein for particle export. J Virol 73:2613–2621
     [Google Scholar]
  22. Rethwilm A., Baunach G., Netzer K.-O., Maurer B., Borisch B., ter Meulen V. 1990; Infectious DNA of the human spumaretrovirus. Nucleic Acids Res 18:733–738 [CrossRef]
     [Google Scholar]
  23. Russell D. W., Miller A. D. 1996; Foamy virus vectors. J Virol 70:217–222
     [Google Scholar]
  24. Saïb A., Puvion-Dutilleul F., Schmid M., Périès J., de Thé H. 1997; Nuclear targeting of incoming human foamy virus Gag proteins involves a centriolar step. J Virol 71:1155–1161
     [Google Scholar]
  25. Schliephake A. W., Rethwilm A. 1994; Nuclear localization of foamy virus Gag precursor protein. J Virol 68:4946–4954
     [Google Scholar]
  26. Trobridge G., Russell D. W. 2004; Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors. J Virol 78:2327–2335 [CrossRef]
     [Google Scholar]
  27. Uchida N., Sutton R. E., Friera A. M., He D., Reitsma M. J., Chang W. C., Veres G., Scollay R., Weissman I. L. 1998; HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells. Proc Natl Acad Sci U S A 95:11939–11944 [CrossRef]
     [Google Scholar]
  28. Vassilopoulos G., Trobridge G., Josephson N. C., Russell D. W. 2001; Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors. Blood 98:604–609 [CrossRef]
     [Google Scholar]
  29. Yu S. F., Sullivan M. D., Linial M. L. 1999; Evidence that the human foamy virus genome is DNA. J Virol 73:1565–1572
     [Google Scholar]
  30. Zucali J. R., Ciccarone T., Kelley V., Park J., Johnson C. M., Mergia A. 2002; Transduction of umbilical cord blood CD34+ NOD/SCID-repopulating cells by simian foamy virus type 1 (SFV-1) vector. Virology 302:229–235 [CrossRef]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.80210-0
Loading
Cell-cycle dependence of foamy virus vectors
J. Gen. Virol. 85, 2925 (2004); https://doi.org/10.1099/vir.0.80210-0
/content/journal/jgv/10.1099/vir.0.80210-0
/content/journal/jgv/10.1099/vir.0.80210-0
Loading

Data & Media loading...

Supplements

Supplementary material 1

PDF

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error