1887

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Volume 87, Issue 12

Detection of the prototype of a potential novel genus in the family in association with canine epidermodysplasia verruciformis Free

Abstract

Epidermodysplasia verruciformis (EV) is a rare human genetic predisposition to develop flat warts, some of which subsequently undergo cancer transformation. Some human papillomaviruses (HPVs), i.e. HPV 5 and 8, have been associated with cancer development as a sequela of EV. As similar diseases have been observed in dogs, it was hypothesized that unknown canine papillomaviruses (CPVs) may exist and that they may be present in cases of canine EV. Consequently, DNA was extracted from a malignant lesion of a dog with EV and circular DNA was amplified by multiple-primed rolling-circle amplification (RCA). Indeed, sequence determination and analysis of the RCA-amplified and cloned DNA from a malignant canine EV lesion resulted in the detection and primary description of a third CPV (CPV3). Typical papillomavirus genes were identified, with deduced amino acid similarities ranging from 20 to 57 % for E1, E2, E6, E7, L1 and L2, respectively. According to the sequence of the L1 gene, which is used for papillomavirus classification, the new isolate meets the majority of criteria needed to declare detection of a novel genus among the papillomaviruses. Thus, CPV3 may represent the prototype of this novel genus. As the novel virus was found in a dog in association with lesions reminiscent of human EV, it should be interesting to test in the future whether this condition can be reproduced in experimental animals. If such were the case, a new model for EV could be established.

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2006-12-01
2024-04-26
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References

  1. Androphy E. J., Lowy D. R., Schiller J. T. 1987; Bovine papillomavirus E2 trans -activating gene product binds to specific sites in papillomavirus DNA. Nature 325:70–73 [CrossRef]
     [Google Scholar]
  2. Antonsson A., Forslund O., Ekberg H., Sterner G., Hansson B. G. 2000; The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses. J Virol 74:11636–11641 [CrossRef]
     [Google Scholar]
  3. Briggs O. M. 1985; Lentiginosis profusa in the pug: three case reports. J Small Anim Pract 26:675–680 [CrossRef]
     [Google Scholar]
  4. Dean F. B., Nelson J. R., Giesler T. L., Lasken R. S. 2001; Rapid amplification of plasmid and phage DNA using Phi29 DNA polymerase and multiply-primed rolling circle amplification. Genome Res 11:1095–1099 [CrossRef]
     [Google Scholar]
  5. de Oliveira W., Festa Neto C., Rady P. L., Tyring S. K. 2003; Clinical aspects of epidermodysplasia verruciformis. J Eur Acad Dermatol Venereol 17:394–398 [CrossRef]
     [Google Scholar]
  6. de Villiers E.-M., Fauquet C., Broker T. R., Bernard H.-U., zur Hausen H. 2004; Classification of papillomaviruses. Virology 324:17–27 [CrossRef]
     [Google Scholar]
  7. Felsenstein J. 2004 phylip (Phylogeny Inference Package), version 3.6. Department of Genome Sciences University of Washington; Seattle, USA:
     [Google Scholar]
  8. Gross T. L., Brimacomb B. H. 1986; Multifocal intraepidermal carcinoma in a dog histologically resembling Bowen's disease. Am J Dermatopathol 8:509–515 [CrossRef]
     [Google Scholar]
  9. Jeanmougin F., Thompson J. D., Gouy M., Higgins D. G., Gibson T. J. 1998; Multiple sequence alignment with Clustal X. Trends Biochem Sci 23:403–405 [CrossRef]
     [Google Scholar]
  10. Li Y.-H., Chen G., Dong X.-P., Chen H.-D. 2004; Detection of epidermodysplasia verruciformis-associated human papillomavirus DNA in nongenital seborrhoeic keratosis. Br J Dermatol 151:1060–1065 [CrossRef]
     [Google Scholar]
  11. Morrison C., Eliezri Y., Magro C., Nuovo G. J. 2002; The histologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients. J Cutan Pathol 29:480–489 [CrossRef]
     [Google Scholar]
  12. Münger K., Baldwin A., Edwards K. M., Hayakawa H., Nguyen C. L., Owens M., Grace M., Huh K. 2004; Mechanisms of human papillomavirus-induced oncogenesis. J Virol 78:11451–11460 [CrossRef]
     [Google Scholar]
  13. Nagata M., Nanko H., Moriyama A., Washizu T., Ishida T. 1995; Pigmented plaques associated with papillomavirus infection in dogs: is this epidermodysplasia verruciformis?. Vet Dermatol 6:179–185 [CrossRef]
     [Google Scholar]
  14. Nuovo G. J., Ishag M. 2000; The histologic spectrum of epidermodysplasia verruciformis. Am J Surg Pathol 24:1400–1406 [CrossRef]
     [Google Scholar]
  15. Rector A., Bossart G. D., Ghim S.-J., Sundberg J. P., Jenson A. B., Van Ranst M. 2004a; Characterization of a novel close-to-root papillomavirus from a Florida manatee by using multiply primed rolling-circle amplification: Trichechus manatus latirostris papillomavirus type 1. J Virol 78:12698–12702 [CrossRef]
     [Google Scholar]
  16. Rector A., Tachezy R., Van Ranst M. 2004b; A sequence-independent strategy for detection and cloning of circular DNA virus genomes by using multiply primed rolling-circle amplification. J Virol 78:4993–4998 [CrossRef]
     [Google Scholar]
  17. Rector A., Tachezy R., Van Doorslaer K., Macnamara T., Burk R. D., Sundberg J. P., Van Ranst M. 2005; Isolation and cloning of a papillomavirus from a North American porcupine by using multiply primed rolling-circle amplification: the Erethizon dorsatum papillomavirus type 1. Virology 331:449–456 [CrossRef]
     [Google Scholar]
  18. Scott D. W., Miller W. H., Griffin C. E. 2001; Viral, rickettsial and protozoal diseases. In Muller & Kirk's Small Animal Dermatology , 6th edn. pp  517–542 Edited by Scott D. W., Miller W. H., Griffin C. E. Philadelphia, PA: W. B. Saunders;
     [Google Scholar]
  19. Stokking L. B., Ehrhart E. J., Lichtensteiger C. A., Campbell K. L. 2004; Pigmented epidermal plaques in three dogs. J Am Anim Hosp Assoc 40:411–417 [CrossRef]
     [Google Scholar]
  20. Tanabe C., Kano R., Nagata M., Nakamura Y., Watanabe S., Hasegawa A. 2000; Molecular characteristics of cutaneous papillomavirus from the canine pigmented epidermal nevus. J Vet Med Sci 62:1189–1192 [CrossRef]
     [Google Scholar]
  21. Walder E. J. 1997; Malignant transformation of a pigmented epidermal nevus in a dog. Vet Pathol 34:505
     [Google Scholar]
  22. Wilson V. G., West M., Woytek K., Rangasamy D. 2002; Papillomavirus E1 proteins: form, function, and features. Virus Genes 24:275–290 [CrossRef]
     [Google Scholar]
  23. Zaugg N., Nespeca G., Hauser B., Ackermann M., Favrot C. 2005; Detection of novel papillomaviruses in canine mucosal, cutaneous and in situ squamous cell carcinomas. Vet Dermatol 16:290–298 [CrossRef]
     [Google Scholar]
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Detection of the prototype of a potential novel genus in the family Papillomaviridae in association with canine epidermodysplasia verruciformis
J. Gen. Virol. 87, 3551 (2006); https://doi.org/10.1099/vir.0.82305-0
/content/journal/jgv/10.1099/vir.0.82305-0
/content/journal/jgv/10.1099/vir.0.82305-0
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