1887

Abstract

SUMMARY

A measles virus (Halle SSPE isolate) induced ring plaque phenomenon (concentric rings of living and dead cells) has been shown to be associated with the temperature-dependent production of interfering particles. The interfering particles have been purified by potassium tartrate linear gradient centrifugation and have buoyant densities of 1.15 g/ml (M particle) and 1.06 g/ml (L particle) respectively. Both interfering particle populations have been shown to decrease the yield of wild-type measles virus from infected cells by 50% when co-infection experiments were performed. Neither the M or L particle population interfered with the growth of VSV in the same host-cell system.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-56-1-195
1981-09-01
2024-04-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/56/1/JV0560010195.html?itemId=/content/journal/jgv/10.1099/0022-1317-56-1-195&mimeType=html&fmt=ahah

References

  1. Hall W., Martin S. 1973; Purification and characterization of measles virus. Journal of General Virology 19:175–188
    [Google Scholar]
  2. Hall W., Martin S. 1974; Defective interfering particles produced during the replication of measles virus. Medical Microbiology and Immunology 160:155–164
    [Google Scholar]
  3. Horta-Barbosa L., Fuccillo D., Sever J., Zeman W. 1969; Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy. Nature, London 221:974
    [Google Scholar]
  4. Huang A. 1973; Defective interfering particles. Annual Review of Microbiology 27:101–117
    [Google Scholar]
  5. Macdonald R. 1978; Ring plaque formation in infectious pancreatic necrosis virus correlates with defective interfering particle production. Journal of General Virology 41:623–628
    [Google Scholar]
  6. Payne F., Baublis J., Itabashi H. 1969; Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. New England Journal of Medicine 281:585–589
    [Google Scholar]
  7. Pfau C., Welsh R., Trowbridge R. 1973; Plaque assays and current concepts of regulation in arenavirus infections. In Lymphocytic Choriomeningitis Virus and Other Arenaviruses Edited by Lehmann-Grube F. Berlin: Springer-Verlag;
    [Google Scholar]
  8. Schleuderberg A., Nakamura M. 1967; A salt-dependent hemagglutinating particle from measles-infected cells. Virology 33:297–306
    [Google Scholar]
  9. Ter Meulen V., Hall W. 1978; Slow virus infections of the nervous system: virological, immunological and pathogenic considerations. Journal of General Virology 41:1–25
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-56-1-195
Loading
/content/journal/jgv/10.1099/0022-1317-56-1-195
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error