1887

Abstract

Summary

Intramuscular injection of mice with 2000 IU/g partially purified murine interferon (IFN) alpha/beta 3 h before the induction of IFN by intraperitoneally administered 3 µg/g poly rI:rC enhanced early IFN production. The differences between the serum IFN levels of IFN-pretreated and control animals were about 10-fold during the first 2 to 3 h of IFN production. In later stages these differences tended to decrease, and from 8 h post-induction they disappeared. IFN exerted its priming activity equally after intravenous, intraperitoneal or intramuscular injection. A similar enhancement of IFN production was observed when it was induced by poly rI:rC administered either intraperitoneally or intramuscularly. The duration of IFN pretreatment influenced the establishment of the primed state. Following administration of 2000 IU/g murine IFN alpha/beta intramuscularly, maximal priming developed after 3 h, and no primed IFN response was detected when the inoculation of IFN preceded inducer administration by 12 h or more. The manifestation of priming was optimal when 1500 to 3000 IU/g pretreating doses of IFN were applied. Reduction of the amount of injected IFN below this level markedly decreased priming, indicating a time- and dose-dependent induction of priming .

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1986-12-01
2024-05-02
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References

  1. Abreu S. L., Bancroft F. C., Stewart W. E. ii 1979; Interferon priming. Effects on interferon messenger RNA. Journal of Biological Chemistry 254:4114–4118
    [Google Scholar]
  2. Arenzana-Seisdedos F., Virelizier J.-L. 1983; Interferons as macrophage-activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide-stimulated human monocytes. European Journal of Immunology 13:437–440
    [Google Scholar]
  3. Billiau A., Heremans H., Ververken D., Van Damme J., Carton H., De Somer P. 1981; Tissue distribution of human interferons after exogenous administration in rabbits, monkeys, and mice. Archives of Virology 68:19–25
    [Google Scholar]
  4. Blomgren H., Einhorn S. 1981; Lymphokine production by PHA-stimulated human lymphocytes is enhanced by interferon. International Archives of Allergy and Applied Immunology 66:173–178
    [Google Scholar]
  5. Brehm G., Kirchner H. 1986; Analysis of the interferons induced in mice in vivo and in macrophages in vitro by Newcastle disease virus and by polyinosinic-polycytidylic acid. Journal of Interferon Research 6:21–28
    [Google Scholar]
  6. Cantell K., Hirvoven S., Mogensen K. E., Pyhälä L. 1974; Human leukocyte interferon: production, purification, stability and animal experiments. In The Production and Use of Interferon for the Treatment and Prevention of Human Virus Infections (In Vitro Monograph vol 3 pp 35–38 Edited by Waymouth C. Rockville: Tissue Culture Association;
    [Google Scholar]
  7. Clark J. M., Hirtenstein M. D. 1981; High yield culture of human fibroblasts on microcarriers: a first step in production of fibroblast-derived interferon (human beta interferon). Journal of Interferon Research 1:391–400
    [Google Scholar]
  8. Degré M., Rollag H. JR 1979; Influence of interferon on the in vivo phagocytic activity of reticuloendothelial system cells. Journal of the Reticuloendothelial Society 25:489–493
    [Google Scholar]
  9. De Maeyer-Guignard J., Cachard A., De Maeyer E. 1980; Electrophoretically pure mouse interferon has priming but no blocking activity in poly (I:C)-induced cells. Virology 102:222–225
    [Google Scholar]
  10. Dinh PH. N., Béládi I., Rosztoczy I., Toth M. 1980; Modulation of lymphokine production by interferon. Journal of Interferon Research 1:23–30
    [Google Scholar]
  11. Edy V. G., Billiau A., De Somer P. 1976; Comparison of rates of clearance of human fibroblast and leukocyte interferon from the circulatory system of rabbits. Journal of Infectious Diseases 133:A18–A21
    [Google Scholar]
  12. Edy V. G., Augenstein D. C., Edwards C. R., Cruttenden V. F., Lubiniecki A. S. 1982; Large-Scale tissue culture for human IFN-β production. In The Interferon System: A Review to 1982 – Part I (Texas Reports on Biology and Medicine vol 41 pp 169–173 Edited by Baron S., Dianzani F., Stanton G. J. Galveston: University of Texas Medical Branch;
    [Google Scholar]
  13. Endresz V., Toth S., Toth M. 1985; Production of high titre human interferon-gamma in primed leukocyte cultures. Acta microbiologica hungarica 32:395–398
    [Google Scholar]
  14. Fujita T., Kohno S. 1981; Studies on interferon priming: cellular response to viral and nonviral inducers and requirement of protein synthesis. Virology 112:62–69
    [Google Scholar]
  15. Hashimoto H., Shibukawa N., Kojima Y. 1978; The mode of production of endotoxin-induced interferon in rabbit tissue cells. I. Development of priming by pretreatment with interferon. Microbiology and Immunology 22:673–681
    [Google Scholar]
  16. Ho M., Breining M. K., Postic B., Armstrong J. A. 1970; The effect of pre-injections on the stimulation of interferon by a complexed polynucleotide, endotoxin and virus. Annals of the New York Academy of Sciences 173:680–693
    [Google Scholar]
  17. Huang K. 1982; Modulation of phagocytosis. In The Interferon System: A Review to 1982 Part I (Texas Reports on Biology and Medicine vol 41 pp 375–380 Edited by Baron S., Dianzani F., Stanton G. J. Galveston: University of Texas Medical Branch;
    [Google Scholar]
  18. Isaacs A., Burke D. C. 1958; Mode of action of interferon. Nature, London 182:1073–1074
    [Google Scholar]
  19. Ito F., Kobayashi S. 1974; Enhancing effect of interferon pretreatment on interferon production. Japanese Journal of Microbiology 18:223–228
    [Google Scholar]
  20. Ito F., Suzuki J., Kobayashi S. 1975; Requirement of newly synthesized protein for the priming activity of interferon. Japanese Journal of Microbiology 19:87–95
    [Google Scholar]
  21. Lefkowitz S. S., Luna V. E. R. 1984; Priming of bovine interferons. Intervirology 21:221–223
    [Google Scholar]
  22. Machida H., Kawade Y., Watanabe Y. 1984; Antigenicity of mouse interferons induced in vitro and in vivo by poly(I).poly(C). Journal of Interferon Research 3:347–353
    [Google Scholar]
  23. Nagano Y., Maehara N. 1972; Enhancement of endotoxin-induced virus-inhibiting factor or interferon production by pretreatment of the rabbit with Newcastle disease virus. Japanese Journal of Microbiology 16:397–402
    [Google Scholar]
  24. Nir U., Maroteaux L., Cohen B., Mory I. 1985; Priming affects the transcription rate of human interferon-β 1 gene. Journal of Biological Chemistry 260:14242–14247
    [Google Scholar]
  25. Rosztóczy I. 1976; Study of the priming effect of interferon in L cells. I. The primed interferon response and the kinetics of development of priming. Acta virologica 20:472–478
    [Google Scholar]
  26. Rosztóczy I. 1977; Study of the priming effect of interferon in L cells. II. Metabolic requirements for the development of primed state. Acta virologica 21:1–7
    [Google Scholar]
  27. Stewart W. E. II, Gosser L. B., Lockart R. Z. jr 1971; Priming: a non-antiviral function of interferon. Journal of Virology 7:792–801
    [Google Scholar]
  28. Stewart W. E. II, De Clercq E., De Somer P., Berg K., Ogburn C. A., Paucker K. 1973; Antiviral and nonantiviral activity of highly purified interferon. Nature New Biology 246:141–143
    [Google Scholar]
  29. Vilček J., Pearlstein K. T., Le J., Stone-Wolff D. S., Kelker H. C., Yip Y. K. 1983; Interferon-gamma: interactions with other lymphokines. In The Biology of the Interferon System 1983 pp 281–292 Edited by De Maeyer E., Schellekens H. Amsterdam: Elsevier;
    [Google Scholar]
  30. Wallach D., Aderka D., Budilovsky S., Hahn T. 1983; Interferon enhances the production of lymphotoxins and potentiates their cytotoxic effect. In The Biology of the Interferon System 1983 pp 293–303 Edited by De Maeyer E., Schellekens H. Amsterdam: Elsevier;
    [Google Scholar]
  31. Wiranowska-Stewart M., Lin L. S., Braude I. A., Stewart W. E. II 1980; Production, partial purification and characterization of human and murine interferons-type II. Molecular Immunology 17:625–633
    [Google Scholar]
  32. Yershov F. I., Tazulakhova E. B., Novakhatsky A. S. 1976; The effect of combination of different inducers on the refractory state in interferon production. Acta virologica 20:15–22
    [Google Scholar]
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