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Volume 74, Issue 7

Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen Free

Abstract

A 681 nucleotide fragment of the hepatitis B virus (HBV) genome was sequenced that corresponded to the complete gene for hepatitis B surface antigen (HBsAg) in 80 HBsAg- and hepatitis B e antigen (HBeAg)-positive sera of diverse geographical origins. These and 42 previously published HBV sequences within the S gene were used for the construction of a dendrogram. In this comparison, each of the 122 HBsAg genes was found to be related to one or other of the six previously identified genomic groups of HBV, A to F. The HBV strains within each genomic group showed a characteristic geographical distribution. Group A genomes were represented by 23 strains mainly originating in northern Europe and sub-Saharan Africa. The group B and C genomes, represented by 17 and 28 strains respectively, were confined to populations with origins in eastern Asia and the Far East. The group D genomes, represented by 38 strains, were found worldwide, but were the predominant strains in the Mediterranean area, the Near and Middle East, and in south Asia. Group E genomes, represented by nine strains, were indigenous to western sub-Saharan Africa as far south as Angola. There were indications that the F group, made up of six strains, represented the genomic group of HBV among populations with origins in the New World. Thus, HBV has diverged into genomic groups according to the distribution of mankind in the different continents. As well as giving information on the genetic relationship of HBV strains of different geographical origin, this study also provides information on the primary structure of HBsAg in different regions of the world. Such data might prove valuable in explaining the reported failures to obtain protection with current HBV vaccines.

  • Received:
  • Accepted:
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© Journal of General Virology 1993
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1993-07-01
2024-05-02
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References

  1. Bichko V, Pushko P, Dreilina D, Pumpen P, Grens E. 1985; Subtype ayw variant of hepatitis B virus. DNA primary structure analysis.. FEES Letters 185:208–212
     [Google Scholar]
  2. Carman WF, Zanetti AR, Kariyannis P, Waters J, Manzillo G, Tanzi E, Zuckerman AJ, Thomas HC. 1990; Vaccine-induced escape mutant of hepatitis B virus.. Lancet ii:325–329
     [Google Scholar]
  3. Castillio D, Armas-Merino R, Gonzalez MC, Wolff C, Soto JR, Melendez M. 1979; Subtipos de antigeno de superficie de la hepatitis B (HBsAg) en portadores asintomaticos y pacientes de hepatitis B en Chile.. Revista Medica de Chile 107:373
     [Google Scholar]
  4. Courouce AM, Holland PV, Muller JY, Soulier JP. 1976; HBs Antigen Subtypes.. Bibliotheca haematologica 42:1
     [Google Scholar]
  5. CouroucePauty AM, Lemaire JM, Roux JF. 1978; New hepatitis B surface antigen subtypes inside the ad category.. Vox sanguinis 35:304–308
     [Google Scholar]
  6. CouroucePauty AM, Plancon A, Soulier JP. 1983; Distribution of HBsAg subtypes in the world.. Vox sanguinis 44:197–211
     [Google Scholar]
  7. Coursaget P, Bourdil C, Adamowicz P, Chotard J, Diop Mar I, Yvonnet B, Mevelec MN, Barres JL, N’Doye R, Chiron JP. 1987; HBsAg positive reactivity in man not due to hepatitis B virus.. Lancet ii:1354–1358
     [Google Scholar]
  8. Estacio RC, Chavez CC, Okamoto H, Lingao AL, Reyes MT, Domingo E, Mayumi M. 1988; Nucleotide sequence of a hepatitis B virus genome of subtype adw isolated from a Philippino: comparison with the three reported genomes of the same subtype. . Journal of Gastroenterology and Hepatology 3:215–222
     [Google Scholar]
  9. Fujiyama A, Miyanohara A, Nozaki C, Yoneyama T, Ohtomo N, Matsubara K. 1983; Cloning and structural analyses of hepatitis B virus DNAs, subtype adr.. Nucleic Acids Research 11:4601–1610
     [Google Scholar]
  10. Galibert F, Mandart E, Fitoussi F, Tiollais P, Charnay P. 1979; Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli.. Nature, London 281:646–650
     [Google Scholar]
  11. Gan R, Shen L, Chu M, Li Z, Charnay P. 1984; The nucleotide sequence of surface antigen gene of hepatitis B virus subtype adr.. Scientia sinica Series B 27:926–935
     [Google Scholar]
  12. Gan R, Chu M, Shen L, Qian S, Li Z. 1987; The complete nucleotide sequence of the cloned DNA of hepatitis B virus subtype adr in pADR-1.. Scientia sinica Series B 30:507–521
     [Google Scholar]
  13. Harrison TJ, Hopes EA, Oon CJ, Zanetti AR, Zuckerman AJ. 1991; Independent emergence of a vaccine-induced escape mutant of hepatitis B virus.. Journal of Hepatology 13:105–107
     [Google Scholar]
  14. Heyerdahl T. 1952 American Indians in the Pacific:the Theory Behind the Kon-Tiki Expedition London: Allen and Unwin;
     [Google Scholar]
  15. Kanagawa H, Tsuda F, Machida A, Kojima M, Ishijima A, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M. 1992; Hepatitis B surface antigen particles of subtype adw and adr, and compound subtype (adwr) in symptom-free carriers in Japan.. Journal of Medical Virology 37:288–293
     [Google Scholar]
  16. Kobayashi M, Koike K. 1984; Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization.. Gene 30:227–232
     [Google Scholar]
  17. Lai ME, Melis A, Mazzoleni AP, Uccheddu P, Balestrieri A. 1991; Sequence analysis of hepatitis B virus genome of a new mutant of ayw subtype isolated in Sardinia.. Nucleic Acids Research 19:5078
     [Google Scholar]
  18. McMahon G, Ehrlich PH, Moustafa ZA, McCarthy LA, Dottavio D, Tolpin MD, Nadler PI, Ostberg L. 1992; Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients.. Hepatology 15(5):757–766
     [Google Scholar]
  19. Magnius LO, Berg R, Bjorvatn B, Svedmyr A. 1973; Shift in viral strains of hepatitis B in Stockholm as reflected by subtypes of hepatitis B antigen.. Scandinavian Journal of Infectious Diseases 5:81–84
     [Google Scholar]
  20. Mazzur S, Falker D, Blumberg BS. 1973; Geographical variation of the ‘ w’ subtype of Australia antigen.. Nature New Biology 243:44–47
     [Google Scholar]
  21. Norder H, Hammas B, Magnius LO. 1990; Typing of hepatitis B virus genomes by a simplified polymerase chain reaction. . Journal of Medical Virology 31:215–221
     [Google Scholar]
  22. Norder H, Hammas B, Lofdahl S, Courouce AM, Magnius LO. 1992a; Comparison of the amino acid sequence of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains. . Journal of General Virology li 73:1201–1208
     [Google Scholar]
  23. Norder H, Courouce AM, Magnius LO. 1926; Molecular basis of hepatitis B virus serotype variations within the four major subtypes. . Journal of General Virology 73:3141–3145
     [Google Scholar]
  24. Okamoto H, Imai M, Shimozaki M, Hoshi Y, Iizuka H, Gotanda T, Tsuda F, Miyakawa Y, Mayumi M. 1986; Nucleotide sequence of a cloned hepatitis B virus genome subtype ayr: comparison with genomes of the other three subtypes.. Journal of General Virology 67:2305–2314
     [Google Scholar]
  25. Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M. 1987a; Genomic heterogeneity of hepatitis B virus in a 54-year old woman who contracted the infection through materno-fetal transmission. . Japanese Journal of Experimental Medicine 57:231–236
     [Google Scholar]
  26. Okamoto H, Imai M, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M. 1987b; Point mutation in the S gene of hepatitis B virus for a d/y or wjr subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr.. Journal of Virology 61:3030–3034
     [Google Scholar]
  27. Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, Mayumi M. 1988; Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. . Journal of Virology 69:2575–2583
     [Google Scholar]
  28. Ono Y, Onda H, Sasada H, Igarashi K, Sugino Y, Nishioka K. 1983; The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw.. Nucleic Acids Research 11:1747–1757
     [Google Scholar]
  29. Pasek M, Goto T, Gilbert H, Zink B, Schaller H, Mackay P, Leaobetter G, Murray K. 1979; Hepatitis B virus genes and their expression in E. coli.. Nature, London 282:575–579
     [Google Scholar]
  30. Rho HM, Kim K, Hytrn SW, Kim YS. 1989; The nucleotide sequence and reading frames of a mutant hepatitis B virus subtypeadr.. Nucleic Acids Research 17:2124
     [Google Scholar]
  31. Rivkina MB, Lunin VG, Mahov AM, Tikchonenko TI, Kukain RA. 1988; Nucleotide sequence of integrated hepatitis B virus DNA and human flanking regions in the genome of the PLC/PRF/5 cell line.. Gene 64:285–296
     [Google Scholar]
  32. Robertson BH, Jansen RW, Khanna B, Totsuka A, Nainan OV, Siege G, Widell A, Margoeis HS, Isomura S, Ito K, Ishizu T, Moritsugu Y, Lemon SM. 1992; Genetic relatedness of hepatitis A virus strains recovered from differentgeographical regions.. Journal of General Virology 73:1365–1377
     [Google Scholar]
  33. Sastrosoewignjo R, Okamoto H, Mayumi M, Warsa UC, Sujud . 1985; The complete nucleotide sequence of an HBV DNAclone of subtype ad (pRTB299) from Indonesia.. ICMR Annals 5:39–50
     [Google Scholar]
  34. Sastrosoewignjo RI, Omi S, Okamoto H, Mayumi M, Rustam M, Sujud . 1987; The complete nucleotide sequence of HBV DNA clone of subtype adw (pMND 122) from Menado in SulaweslIsland, Indonesia.. ICMR Annals 7:51–60
     [Google Scholar]
  35. Sastrosoewignjo RI, Sandjaja B, Okamoto H. 1991; Molecular epidemiology of hepatitis B virus in Indonesia.. Journal ofGastroenterology and Hepatology 6:491–498
     [Google Scholar]
  36. Skinhoj P. 1979; Hepatitis B virus infection in children.A seroepidemiologicalstudy in three endemic areas.. ransactions of theRoyal Society of Tropical Medicine and Hygien 73:549–552
     [Google Scholar]
  37. Sneath PHA, Sokal RR. 1973 Numerical Taxonomy San Francisco: Freeman;
     [Google Scholar]
  38. Stevens CE, Neurath AR, Beasly RP, Szmuness W. 1979; HBeAg and anti-HBe detection by radioimmunoassay. Correlationwith vertical transmission of hepatitis B virus in Taiwan.. Journal of Medical Virology 3:237–241
     [Google Scholar]
  39. Stirk HJ, Thornton JM, Howard CR. 1992; A topologicalmodel for hepatitis B surface antigen.. Intervirology 33:148–158
     [Google Scholar]
  40. Tabor A, Bayley AC, Cairns J, Pelleu L, Gerety RJ. 1985; Horizontal transmission of hepatitis B virus among childrenand adults in five rural villages in Zambia.. Journal of MedicalVirology 15:113–120
     [Google Scholar]
  41. Tong SLI, Jr, Vitvitski L, Trepo C. 1990; Active hepatitis B virus replication in the presence of anti-HBe is associated with viralvariants containing an inactive pre-C region.. Virology 176:596–603
     [Google Scholar]
  42. Tran A, Kremsdorf D, Capel F, Housset C, Dauguet C, Petit MA, Brechot C. 1991; Emergence of and takeover by hepatitis B virus (HBV) rearrangements in the pre-S/S and pre-C/Cgenes during chronic HBV infection.. Journal of Virology 65:3566–3574
     [Google Scholar]
  43. Valenzuela P, Quiroga M, Zaldivar J, Gray P, Rutter WJ. 1980; The nucleotide sequence of the hepatitis B viral genomeand the identification of the major viral genes. In ICN-UCLA Symposia on Animal Virus Genetics pp. 57–70Edited by Fields B, Jacnisch R, Fox C. New York: Academic Press;
     [Google Scholar]
  44. Vaudin M, Wolstenholme AJ, Tsiquaye KN, Zuckerma AJ, Harrison TJ. 1988; The complete nucleotide sequence of the genome of a hepatitis B virus isolated from a naturally infected chimpanzee.. Journal of General Virology 69:1383–1389
     [Google Scholar]
  45. Yamashita Y, Kurashina S, Miyakawa Y, Mayumi M. 1976; South to north gradient in distribution of the r determinant of hepatitis B surface antigen in Japan.. Journal of Infectious Diseases 131:567–569
     [Google Scholar]
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Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen
J. Gen. Virol. 74, 1341 (1993); https://doi.org/10.1099/0022-1317-74-7-1341
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/content/journal/jgv/10.1099/0022-1317-74-7-1341
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