1887

Abstract

Clinical and laboratory markers of simian immunodeficiency virus (SIV) infection were studied during the first 3 months after intravenous inoculation of rhesus macaques. Virus-binding serum antibody titres were correlated strongly with disease progression (< 0·005) and were predictive of disease outcome by 7 weeks after inoculation. Low virusbinding serum antibody responses to SIV occurred in animals that also showed acute depletion of circulating CD20 B cells. Acute damage to the CD4 T cell and CD20 B cell populations rendered some animals incapable of mounting virus-specific antibody responses and these macaques became the rapidly progressing cases comprising approximately 20– 30% of infected animal cohorts.

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1998-10-01
2024-05-07
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References

  1. Carbonari M., Pesce A. M., Cibati M., Modica A., Dell’Anna L., D’Offizi G., Angelici A., Uccini S., Modesti A., Fiorilli M. 1997; Death of bystander cells by a novel pathway involving early mitochondrial damage in human immunodeficiency virus-related lympha- denopathy. Blood 90:209–216
    [Google Scholar]
  2. Chalifoux L. V., King N. W., Daniel M. D., Kannagi M., Desrosiers R. C., Sehgal P. K., Waldron L. M., Hunt R. D., Letvin N. L. 1986; Lymphoproliferative syndrome in an immunodeficient rhesus monkey naturally infected with an HTLV-III like virus (STLV-III). Laboratory Investigation 55:43–50
    [Google Scholar]
  3. Chargelegue D., Stanley C. M., O’Toole M., Colvin B. T., Steward M. W. 1995; gG antibodies to gag p24 and p17 in HIV- 1-infected patients correlates with disease progression. Clinical and Experimental Immunology 99:175–181
    [Google Scholar]
  4. Daniel M. D., Letvin N. L., King N. W., Kannagi M., Sehgal P. K., Hunt R. D., Kanki P. J., Essex M., Desrosiers R. C. 1985; Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228:1201–1204
    [Google Scholar]
  5. Daniel M. D., Letvin N. L., Sehgal P. K., Hunsmann G., Schmidt D. K., King N. W., Desrosiers R. C. 1987; Long -term persistent infection of macaque monkeys with the simian immunodeficiency virus. Journal of General Virology 68:3183–3189
    [Google Scholar]
  6. Finkel T. H., Tudor-Williams G., Banda N. K., Cotton M. F., Curiel T., Monks C., Baba T. W., Ruprecht R. M., Kupfer A. 1995; Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Medicine 1:129–34
    [Google Scholar]
  7. Fultz P. N., Stricker R. B., McClure H. M., Anderson D. C., Switzer W. M., Horaist C. 1990; MM infection in macaque and mangabey monkeys. Journal of Acquired Immune Deficiency Syndromes 3:319–329
    [Google Scholar]
  8. Haynes B. F., Pantaleo G., Fauci A. S. 1996; Toward an understanding of the correlates of protective immunity to HIV infection. Science 271:324–328
    [Google Scholar]
  9. Kannagi M., Kiyotaki M., Desrosiers R. C., Reimann K. A., King N. W., Waldron L. M., Letvin N. 1986; Humoral immune responses to T cell tropic retrovirus simian T lymphotropic virus type III in monkeys with experimentally induced acquired immune deficiency-like syndrome. Journal of Clinical Investigation 78:1229–1236
    [Google Scholar]
  10. Kindt T. J., Hirsch V. M., Johnson P. R., Sawasdikosol S. 1992; Animal models for acquired immunodeficiency syndrome. Advances in Immunology 52:425–474
    [Google Scholar]
  11. Letvin N. L., King N. W. 1990; Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency viruses of macaques. Journal of Acquired Immune Deficiency Syndromes 3:1023–1040
    [Google Scholar]
  12. Mellors J. W., Rinaldo C. R. Jr Gupta P., White R. M., Todd J. A., Kingsley L. A. 1996; Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272:1167–70
    [Google Scholar]
  13. Michael N. L., Brown A. E., Voigt R. F., Frankel S. S., Mascola J. R., Brothers K. S., Louder M., Birx D. L., Cassol S. A. 1997; Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection: evidence for highly susceptible human hosts. Journal of Infectious Diseases 175:1352–1359
    [Google Scholar]
  14. Otsyula M. G., Miller C. J., Marthas M. L., Van Rompay K. K. A., Collins J. R., Pederson N. C., McChesney M. B. 1996; Virus- induced immunosuppression is linked to rapidly fatal disease in infant rhesus macaques infected with simian immunodeficiency virus. Pediatric Research 39:630–635
    [Google Scholar]
  15. Pauza C. D., Emau P., Salvato M. S., Trivedi P., MacKenzie D., Malkovsky M., Uno H., Schultz K. T. 1993; Pathogenesis of SIVmac251 after a traumatic inoculation of the rectal mucosa in rhesus monkeys. Journal of Medical Primatology 22:154–161
    [Google Scholar]
  16. Pauza C. D., Hinds P. W. II Yin C., McKechnie T. S., Hinds S. B., Salvato M. S. 1997; The lymphocytosis promoting agent pertussis toxin affects virus burden and lymphocyte distribution in the SIV- infected rhesus macaque. AIDS Research and Human Retroviruses 13:87–95
    [Google Scholar]
  17. Pauza C. D., Horejsh D., Wallace M. 1998; Mucosal transmission of virulent and avirulent lentiviruses in macaques. AIDS Research and Human Retroviruses 14:S83–87
    [Google Scholar]
  18. Schnittman S. M., Lane H. C., Higgins S. E., Folks T., Fauci A. S. 1986; Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science 233:1084–1086
    [Google Scholar]
  19. Steger K. K., Dykhuizen M., Mitchen J., Hinds P. W., Preuninger B. L., Wallace M., Thomson J., Lu Y., Pauza C. D. 1998; CD4 + T cell and CD20+ B cell changes that predict rapid disease progression after SHIV89. 6PD inoculation of rhesus macaques. Journal of Virology 72:1600–1605
    [Google Scholar]
  20. Strathdee S. A., Frank J. W., McLaughlin J., Leblanc M., Major C., O’Shaughnessy M. V., Read S. E. 1995; Quantitative measures of Human Immunodeficiency Virus-specific antibodies predict progression to AIDS. Journal of Infectious Diseases 172:1375–1379
    [Google Scholar]
  21. Trivedi P., Meyer K. K., Streblow D. N., Preuninger B. L., Schultz K. T., Pauza C. D. 1994; Selective amplification of simian immunodeficiency virus genotypes after intrarectal inoculation of rhesus monkeys. Journal of Virology 62:7649–7653
    [Google Scholar]
  22. Trivedi P., Horejsh D., Hinds S. B., Hinds P. W. II Wu M. S., Salvato M. S., Pauza C. D. 1996; Intrarectal transmission of simian immunodeficiency virus in rhesus macaques : selective amplification and host responses to transient or persistent viremia. Journal of Virology 70:6876–6883
    [Google Scholar]
  23. Watson A., Ranchalis J., Travis B., McClure J., Sutton W., Johnson P. R., Hu S.-L., Haigwood N. L. 1997; Plasma viremia in macaques infected with simian immunodeficiency virus : plasma viral load early in infection predicts survival. Journal of Virology 71:284–290
    [Google Scholar]
  24. Zhang J., Martin L. N., Watson E. A., Montelaro R. C., West M., Epstein L., Murphey-Corb M. 1988; Simian immunodeficiency virus/delta-induced immunodeficiency disease in rhesus monkeys: relation of antibody response and antigenemia. Journal of Infectious Diseases 158:1277–1286
    [Google Scholar]
  25. Zwart G., van der Hoek L., Valk M., Cornelissen M. T. E., Baan E., Dekker J., Koot M., Kuiken C. L., Goudsmit J. 1994; Antibody responses to HIV-1 envelope and gag epitopes in HIV-1 seroconverters with rapid versus slow disease progression. Virology 201:285–293
    [Google Scholar]
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