f The glycoprotein B homologue of human herpesvirus 6
- Authors: K. Ellinger, F. Neipel, L. Foà-Tomasi, G. Campadelli-Fiume, B. Fleckenstein
- First Published Online: 01 March 1993, Journal of General Virology 74: 495-500, doi: 10.1099/0022-1317-74-3-495
- Subject: Animal
- Issue Published:
The gene for the homologue of herpesvirus glycoprotein B (gB) has been identified in the genome of human herpesvirus 6 (HHV-6), strain U1102, and the nucleotide sequence was determined. The open reading frame encodes a protein of 830 amino acids (93.2K) with the characteristics of a transmembrane glycoprotein and close similarity to the gp58/116 complex of human cytomegalovirus (HCMV). Monoclonal antibodies 2D10 and 2B9 have been shown previously to react with an HHV-6 glycoprotein of apparent M r 112K, and its proteolytic cleavage products of M r 64K and 58K. We show that both monoclonal antibodies detect prokaryotically expressed carboxy-terminal fragments of the HHV-6 gB homologue. This indicates that the HHV-6 gB homologue is probably processed by proteolytic cleavage similar to its equivalents in HCMV and various other herpesviruses.
© Society for General Microbiology 1993 | Published by the Microbiology Society
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