f The complete sequence of a human astrovirus
- Authors: M. M. Willcocks†, T. D. K. Brown, C. R. Madeley, M. J. Carter†
- First Published Online: 01 July 1994, Journal of General Virology 75: 1785-1788, doi: 10.1099/0022-1317-75-7-1785
- Subject: Animal
- Issue Published:
We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). The two closest to the 5′ end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3′ ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae.
Present address: School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, U.K.
© Society for General Microbiology 1994 | Published by the Microbiology Society
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